PMID- 25627231
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1809-4570 (Electronic)
IS  - 0482-5004 (Linking)
VI  - 54
IP  - 4
DP  - 2014 Jul-Aug
TI  - [Vitamin D levels in ankylosing spondylitis: does deficiency correspond to 
      disease activity?].
PG  - 330-4
LID - S0482-5004(14)00128-4 [pii]
LID - 10.1016/j.rbr.2014.03.027 [doi]
AB  - Ankylosing spondylitis (AS) is an inflammatory disorder that presents with 
      arthritis of the axial skeleton, including sacroiliac joints. Vitamin D is a 
      secosteroid hormone with a long-established role in calcium and phosphate 
      homeostasis, and in the regulation of bone formation and resorption. It is now 
      known that vitamin D plays an immunosuppressive role in the body, and there is 
      interest of late in the role of vitamin D in autoimmune diseases. Inflammation 
      may be responsible for some of the loss of bone mineral density seen in AS. We 
      reviewed the literature for studies assessing vitamin D level as a marker of AS 
      disease activity and those examining vitamin D levels in AS in comparison to 
      healthy controls. Four of 7 studies found a significant negative correlation 
      between vitamin D levels and Bath Ankylosing Spondylitis Index (BASDAI), 
      erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). In a review of 
      8 case-control studies, the mean level of 25-hydroxyvitamin D3 was 22.8 +/- 14.1 
      ng/mL in 555 AS patients versus 26.6 +/- 12.5 ng/mL in 557 healthy controls. When 
      compared with a 2-sample t test, vitamin D levels were significantly higher in 
      healthy controls (p < 0.01). We conclude that patients with AS appear to have 
      lower vitamin D levels versus healthy controls; however, the cause is unclear. 
      Existing studies do not demonstrate a consistent link between vitamin D levels 
      and disease activity in AS. Further studies are in need to determine if a 
      causative link exists between vitamin D deficiency and AS.
CI  - Copyright (c) 2014 Elsevier Editora Ltda. All rights reserved.
FAU - Pokhai, Gabriel G
AU  - Pokhai GG
AD  - Departamento de Medicina, Divisao de Reumatologia, Icahn School of Medicine at 
      Mount Sinai, Queens Hospital Center, Nova York, NY, EUA. Electronic address: 
      gabriel.pokhai@mountsinai.org.
FAU - Bandagi, Sabiha
AU  - Bandagi S
AD  - Departamento de Medicina, Divisao de Reumatologia, Icahn School of Medicine at 
      Mount Sinai, Queens Hospital Center, Nova York, NY, EUA.
FAU - Abrudescu, Adriana
AU  - Abrudescu A
AD  - Departamento de Medicina, Divisao de Reumatologia, Icahn School of Medicine at 
      Mount Sinai, Queens Hospital Center, Nova York, NY, EUA.
LA  - por
PT  - Journal Article
PT  - Review
TT  - Niveis de vitamina D na espondilite anquilosante: a deficiencia corresponde a 
      atividade da doenca?
DEP - 20140826
PL  - Brazil
TA  - Rev Bras Reumatol
JT  - Revista brasileira de reumatologia
JID - 0404256
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Humans
MH  - Spondylitis, Ankylosing/*blood/complications
MH  - Vitamin D/*blood
MH  - Vitamin D Deficiency/etiology
OTO - NOTNLM
OT  - Ankylosing Spondylitis
OT  - Autoimmune
OT  - Autoimune
OT  - BASDAI
OT  - Espondilite anquilosante
OT  - Inflamacao
OT  - Inflammation
OT  - Vitamin D
OT  - Vitamina D
EDAT- 2015/01/30 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/01/29 06:00
PHST- 2013/12/23 00:00 [received]
PHST- 2014/03/19 00:00 [accepted]
PHST- 2015/01/29 06:00 [entrez]
PHST- 2015/01/30 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S0482-5004(14)00128-4 [pii]
AID - 10.1016/j.rbr.2014.03.027 [doi]
PST - ppublish
SO  - Rev Bras Reumatol. 2014 Jul-Aug;54(4):330-4. doi: 10.1016/j.rbr.2014.03.027. Epub 
      2014 Aug 26.