PMID- 25628514
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150128
LR  - 20220408
IS  - 1179-5514 (Print)
IS  - 1179-5514 (Electronic)
IS  - 1179-5514 (Linking)
VI  - 8
DP  - 2015
TI  - Combination of linagliptin and metformin for the treatment of patients with type 
      2 diabetes.
PG  - 1-6
LID - 10.4137/CMED.S10360 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a progressive condition requiring long-term 
      treatment. Most patients with T2DM are unable to maintain normoglycemia using 
      metformin alone; thus, combination therapy is a pivotal part of disease 
      management. Addition of the dipeptidyl peptidase-4 inhibitor linagliptin, with 
      its proven efficacy, low propensity for hypoglycemia, and weight neutrality, has 
      been shown to improve glycemic control for patients who are not well controlled 
      with metformin. As patients often have other comorbidities requiring 
      pharmacotherapy, an increase in pill number, different prescribing frequencies, 
      and timing of medications may adversely impact patients' adherence. Studies have 
      shown that treatment nonadherence contributes to increased morbidity, mortality, 
      and healthcare cost. In the United States, the single-pill combination (SPC) of 
      linagliptin/metformin is available in three strengths approved for twice-daily 
      administration: 2.5/500 mg, 2.5/850 mg, and 2.5/1000 mg. The SPC has the 
      potential to reduce pill burden and simplify patients' treatment regimens, 
      thereby promoting improved adherence and efficacy.
FAU - Haak, Thomas
AU  - Haak T
AD  - Diabetes Klinik Bad Mergentheim GmbH & Co. KG, Bad Mergentheim, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150104
PL  - United States
TA  - Clin Med Insights Endocrinol Diabetes
JT  - Clinical medicine insights. Endocrinology and diabetes
JID - 101578235
PMC - PMC4284079
OTO - NOTNLM
OT  - combination therapy
OT  - dipeptidyl peptidase-4 inhibitor
OT  - metformin
OT  - single-pill combination
EDAT- 2015/01/30 06:00
MHDA- 2015/01/30 06:01
PMCR- 2015/01/04
CRDT- 2015/01/29 06:00
PHST- 2014/09/17 00:00 [received]
PHST- 2014/11/16 00:00 [revised]
PHST- 2014/11/18 00:00 [accepted]
PHST- 2015/01/29 06:00 [entrez]
PHST- 2015/01/30 06:00 [pubmed]
PHST- 2015/01/30 06:01 [medline]
PHST- 2015/01/04 00:00 [pmc-release]
AID - cmed-8-2015-001 [pii]
AID - 10.4137/CMED.S10360 [doi]
PST - epublish
SO  - Clin Med Insights Endocrinol Diabetes. 2015 Jan 4;8:1-6. doi: 
      10.4137/CMED.S10360. eCollection 2015.