PMID- 25628546 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20150128 LR - 20201001 IS - 1662-5153 (Print) IS - 1662-5153 (Electronic) IS - 1662-5153 (Linking) VI - 8 DP - 2014 TI - Episodic memory and self-reference via semantic autobiographical memory: insights from an fMRI study in younger and older adults. PG - 449 LID - 10.3389/fnbeh.2014.00449 [doi] LID - 449 AB - Self-referential processing relies mainly on the medial prefrontal cortex (MPFC) and enhances memory encoding (i.e., Self-Reference Effect, SRE) as it improves the accuracy and richness of remembering in both young and older adults. However, studies on age-related changes in the neural correlates of the SRE on the subjective (i.e., autonoetic consciousness) and the objective (i.e., source memory) qualitative features of episodic memory are lacking. In the present fMRI study, we compared the effects of a self-related (semantic autobiographical memory task) and a non self-related (general semantic memory task) encoding condition on subsequent episodic memory retrieval. We investigated encoding-related activity during each condition in two groups of 19 younger and 16 older adults. Behaviorally, the SRE improved subjective memory performance in both groups but objective memory only in young adults. At the neural level, a direct comparison between self-related and non self-related conditions revealed that SRE mainly activated the cortical midline system, especially the MPFC, in both groups. Additionally, in older adults and regardless of the condition, greater activity was found in a fronto-parietal network. Overall, correlations were noted between source memory performance and activity in the MPFC (irrespective of age) and visual areas (mediated by age). Thus, the present findings expand evidence of the role of the MPFC in self-referential processing in the context of source memory benefit in both young and older adults using incidental encoding via semantic autobiographical memory. However, our finding suggests that its role is less effective in aging. FAU - Kalenzaga, Sandrine AU - Kalenzaga S AD - Memory and Cognition Laboratory, Institut de Psychologie, Universite Paris Descartes, Sorbonne Paris Cite Boulogne-Billancourt, France ; Center of Psychiatry and Neurosciences, INSERM UMR S894, Universite Paris Descartes Paris, France ; Research Center in Cognition and Learning, UMR-CNRS 7295, Universite de Poitiers Poitiers, France. FAU - Sperduti, Marco AU - Sperduti M AD - Memory and Cognition Laboratory, Institut de Psychologie, Universite Paris Descartes, Sorbonne Paris Cite Boulogne-Billancourt, France ; Center of Psychiatry and Neurosciences, INSERM UMR S894, Universite Paris Descartes Paris, France. FAU - Anssens, Adele AU - Anssens A AD - Memory and Cognition Laboratory, Institut de Psychologie, Universite Paris Descartes, Sorbonne Paris Cite Boulogne-Billancourt, France ; Center of Psychiatry and Neurosciences, INSERM UMR S894, Universite Paris Descartes Paris, France. FAU - Martinelli, Penelope AU - Martinelli P AD - Memory and Cognition Laboratory, Institut de Psychologie, Universite Paris Descartes, Sorbonne Paris Cite Boulogne-Billancourt, France ; Center of Psychiatry and Neurosciences, INSERM UMR S894, Universite Paris Descartes Paris, France. FAU - Devauchelle, Anne-Dominique AU - Devauchelle AD AD - Department of Radiology, Centre Hospitalier Sainte-Anne, Universite Paris Descartes, Sorbonne Paris Cite Paris, France. FAU - Gallarda, Thierry AU - Gallarda T AD - Center of Psychiatry and Neurosciences, INSERM UMR S894, Universite Paris Descartes Paris, France ; Laboratory of Physiopathology of Psychiatric Diseases, Centre Hospitalier Sainte Anne Paris, France. FAU - Delhommeau, Marion AU - Delhommeau M AD - Memory and Cognition Laboratory, Institut de Psychologie, Universite Paris Descartes, Sorbonne Paris Cite Boulogne-Billancourt, France ; Center of Psychiatry and Neurosciences, INSERM UMR S894, Universite Paris Descartes Paris, France. FAU - Lion, Stephanie AU - Lion S AD - Department of Radiology, Centre Hospitalier Sainte-Anne, Universite Paris Descartes, Sorbonne Paris Cite Paris, France. FAU - Amado, Isabelle AU - Amado I AD - Center of Psychiatry and Neurosciences, INSERM UMR S894, Universite Paris Descartes Paris, France ; Laboratory of Physiopathology of Psychiatric Diseases, Centre Hospitalier Sainte Anne Paris, France. FAU - Krebs, Marie-Odile AU - Krebs MO AD - Center of Psychiatry and Neurosciences, INSERM UMR S894, Universite Paris Descartes Paris, France ; Laboratory of Physiopathology of Psychiatric Diseases, Centre Hospitalier Sainte Anne Paris, France. FAU - Oppenheim, Catherine AU - Oppenheim C AD - Center of Psychiatry and Neurosciences, INSERM UMR S894, Universite Paris Descartes Paris, France ; Department of Radiology, Centre Hospitalier Sainte-Anne, Universite Paris Descartes, Sorbonne Paris Cite Paris, France. FAU - Piolino, Pascale AU - Piolino P AD - Memory and Cognition Laboratory, Institut de Psychologie, Universite Paris Descartes, Sorbonne Paris Cite Boulogne-Billancourt, France ; Center of Psychiatry and Neurosciences, INSERM UMR S894, Universite Paris Descartes Paris, France ; Institut Universitaire de France France. LA - eng PT - Journal Article DEP - 20150113 PL - Switzerland TA - Front Behav Neurosci JT - Frontiers in behavioral neuroscience JID - 101477952 PMC - PMC4292587 OTO - NOTNLM OT - aging OT - autobiographical memory OT - autonoetic consciousness OT - medial prefrontal cortex OT - self-reference effect OT - semantic memory OT - source memory EDAT- 2015/01/30 06:00 MHDA- 2015/01/30 06:01 PMCR- 2014/01/01 CRDT- 2015/01/29 06:00 PHST- 2014/08/17 00:00 [received] PHST- 2014/12/15 00:00 [accepted] PHST- 2015/01/29 06:00 [entrez] PHST- 2015/01/30 06:00 [pubmed] PHST- 2015/01/30 06:01 [medline] PHST- 2014/01/01 00:00 [pmc-release] AID - 10.3389/fnbeh.2014.00449 [doi] PST - epublish SO - Front Behav Neurosci. 2015 Jan 13;8:449. doi: 10.3389/fnbeh.2014.00449. eCollection 2014.