PMID- 25629040
OWN - NLM
STAT- MEDLINE
DCOM- 20150928
LR  - 20181202
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2015
DP  - 2015
TI  - Riluzole stimulates BDNF release from human platelets.
PG  - 189307
LID - 10.1155/2015/189307 [doi]
LID - 189307
AB  - Brain-derived neurotrophic factor (BDNF) has several functions in the central 
      nervous system, where it contributes to brain development and its functionality 
      through affecting neuronal survival and activity and also modulating 
      neurotransmitter levels. This neurotrophin is also found in the serum, but its 
      origin and peripheral function remain unknown. Although the source of circulating 
      BDNF is uncertain, it is stored in platelets and can be released through 
      pharmacological treatment. Decreased levels of BDNF in the serum have been 
      related to the pathophysiology of depression, and this relationship is reinforced 
      by the reversal of this condition by treatment with antidepressants. Recently, 
      riluzole has been proposed for the treatment of depression because it has the 
      ability to lower extracellular glutamate levels and increase BDNF expression; and 
      both mechanisms could be associated with its antidepressant action. Considering 
      that riluzole enhances BDNF levels in the serum of patients, we investigated if 
      treatment with this drug could stimulate the release of this neurotrophin from 
      human platelets obtained from healthy subjects. When platelets were incubated 
      with riluzole for 4 h, the basal value of BDNF (92.9 +/- 11.1 pg 10(-6) platelets) 
      was significantly increased (P < 0.05, n = 27). This stimulatory effect was 
      achieved at low concentrations of riluzole (from 10 microM) and was not observed when 
      platelets were incubated with the drug for 24 h. The direct action of riluzole 
      evoking BDNF release from human platelets at therapeutic concentrations is 
      important and may contribute to the understanding of its mechanisms of action in 
      the treatment of depression.
FAU - Turck, Patrick
AU  - Turck P
AD  - Department of Morphological Sciences, Institute of Basic Health Sciences, Federal 
      University of Rio Grande do Sul, Rua Sarmento Leite, 500, 90050-170 Porto Alegre, 
      RS, Brazil.
FAU - Frizzo, Marcos Emilio
AU  - Frizzo ME
AD  - Department of Morphological Sciences, Institute of Basic Health Sciences, Federal 
      University of Rio Grande do Sul, Rua Sarmento Leite, 500, 90050-170 Porto Alegre, 
      RS, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150106
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7LJ087RS6F (Riluzole)
SB  - IM
MH  - Blood Donors
MH  - Blood Platelets/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cell Survival/drug effects
MH  - Humans
MH  - Male
MH  - Riluzole/*pharmacology
PMC - PMC4300019
EDAT- 2015/01/30 06:00
MHDA- 2015/09/29 06:00
PMCR- 2015/01/06
CRDT- 2015/01/29 06:00
PHST- 2014/07/01 00:00 [received]
PHST- 2014/09/17 00:00 [accepted]
PHST- 2015/01/29 06:00 [entrez]
PHST- 2015/01/30 06:00 [pubmed]
PHST- 2015/09/29 06:00 [medline]
PHST- 2015/01/06 00:00 [pmc-release]
AID - 10.1155/2015/189307 [doi]
PST - ppublish
SO  - Biomed Res Int. 2015;2015:189307. doi: 10.1155/2015/189307. Epub 2015 Jan 6.