PMID- 2562914
OWN - NLM
STAT- MEDLINE
DCOM- 19890130
LR  - 20190717
IS  - 0003-990X (Print)
IS  - 0003-990X (Linking)
VI  - 46
IP  - 1
DP  - 1989 Jan
TI  - Neuroendocrine and mood responses to intravenous L-tryptophan in 
      3,4-methylenedioxymethamphetamine (MDMA) users. Preliminary observations.
PG  - 20-2
AB  - 3,4-Methylenedioxymethamphetamine (MDMA; "ecstasy") is a selective serotonin 
      (5-HT) neurotoxin in laboratory animals. To assess its effects on 5-HT function 
      in humans, serum prolactin (PRL) and mood responses to intravenous L-tryptophan 
      were measured in nine recreational users of MDMA and compared with findings from 
      nine matched healthy controls. L-Tryptophan induced a rise in the PRL 
      concentration in controls, but not in MDMA users. Peak change and the area under 
      the curve of the PRL response appeared to be blunted in MDMA users, but the 
      difference from controls did not reach statistical significance. This study 
      provides suggestive evidence of altered 5-HT function in MDMA users, but more 
      definitive studies clearly are needed.
FAU - Price, L H
AU  - Price LH
AD  - Department of Psychiatry, Yale University School of Medicine, New Haven, CN.
FAU - Ricaurte, G A
AU  - Ricaurte GA
FAU - Krystal, J H
AU  - Krystal JH
FAU - Heninger, G R
AU  - Heninger GR
LA  - eng
GR  - MH-00579/MH/NIMH NIH HHS/United States
GR  - MH-36229/MH/NIMH NIH HHS/United States
GR  - MH25642/MH/NIMH NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Arch Gen Psychiatry
JT  - Archives of general psychiatry
JID - 0372435
RN  - 0 (Amphetamines)
RN  - 0 (Designer Drugs)
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 8DUH1N11BX (Tryptophan)
RN  - 9002-62-4 (Prolactin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
CIN - Arch Gen Psychiatry. 1990 Mar;47(3):288-9. PMID: 1968330
MH  - *3,4-Methylenedioxyamphetamine/analogs & derivatives/toxicity
MH  - Adult
MH  - Affect/*drug effects
MH  - *Amphetamines/analogs & derivatives/toxicity
MH  - *Designer Drugs
MH  - Female
MH  - Humans
MH  - Infusions, Intravenous
MH  - Male
MH  - Middle Aged
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Prolactin/*blood
MH  - Serotonin/physiology
MH  - Substance-Related Disorders/*blood/physiopathology/psychology
MH  - Tryptophan/administration & dosage/*pharmacology
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.1001/archpsyc.1989.01810010022003 [doi]
PST - ppublish
SO  - Arch Gen Psychiatry. 1989 Jan;46(1):20-2. doi: 
      10.1001/archpsyc.1989.01810010022003.