PMID- 25629355
OWN - NLM
STAT- MEDLINE
DCOM- 20170929
LR  - 20180319
IS  - 1208-6002 (Electronic)
IS  - 0829-8211 (Linking)
VI  - 93
IP  - 5
DP  - 2015 Oct
TI  - Cardiovascular complications of type 2 diabetes in youth.
PG  - 496-510
LID - 10.1139/bcb-2014-0118 [doi]
AB  - The prevalence of type 2 diabetes mellitus (T2DM) in youth has increased 
      dramatically over the past decades. The literature also suggests that the 
      progression from an impaired glucose tolerance state to established T2DM is more 
      rapid in youth, compared to adults. The presence of significant cardiovascular 
      complications in youth with T2DM, including cardiac, macrovascular, and 
      microvascular remodeling, is another major issue in this younger cohort and poses 
      a significant threat to the healthcare system. However, this issue is only now 
      emerging as a major public health concern, with few data to support optimal 
      treatment targets and strategies to reduce cardiovascular disease (CVD) risk in 
      youth with T2DM. Accordingly, the purpose of this minireview is to better 
      understand the cardiovascular complications in youth with T2DM. We briefly 
      describe the pathophysiology from youth studies, including oxidative stress, 
      inflammation, renin-angiotensin aldosterone system, and epigenetics, which link 
      T2DM and CVD. We also describe the literature concerning the early signs of CVD 
      in youth and potential treatment options to reduce cardiovascular risk.
FAU - Kehler, D Scott
AU  - Kehler DS
AD  - a Health, Leisure and Human Performance Research Institute, Faculty of 
      Kinesiology and Recreation Management, University Of Manitoba.
AD  - b Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre.
FAU - Stammers, Andrew N
AU  - Stammers AN
AD  - a Health, Leisure and Human Performance Research Institute, Faculty of 
      Kinesiology and Recreation Management, University Of Manitoba.
AD  - b Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre.
FAU - Susser, Shanel E
AU  - Susser SE
AD  - b Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre.
AD  - c Department of Physiology, University of Manitoba.
FAU - Hamm, Naomi C
AU  - Hamm NC
AD  - a Health, Leisure and Human Performance Research Institute, Faculty of 
      Kinesiology and Recreation Management, University Of Manitoba.
AD  - b Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre.
FAU - Kimber, Dustin E
AU  - Kimber DE
AD  - a Health, Leisure and Human Performance Research Institute, Faculty of 
      Kinesiology and Recreation Management, University Of Manitoba.
AD  - b Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre.
FAU - Hlynsky, Michael W
AU  - Hlynsky MW
AD  - a Health, Leisure and Human Performance Research Institute, Faculty of 
      Kinesiology and Recreation Management, University Of Manitoba.
AD  - b Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre.
FAU - Duhamel, Todd A
AU  - Duhamel TA
AD  - a Health, Leisure and Human Performance Research Institute, Faculty of 
      Kinesiology and Recreation Management, University Of Manitoba.
AD  - b Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre.
AD  - c Department of Physiology, University of Manitoba.
AD  - d Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada.
LA  - eng
GR  - CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20141207
PL  - Canada
TA  - Biochem Cell Biol
JT  - Biochemistry and cell biology = Biochimie et biologie cellulaire
JID - 8606068
SB  - IM
MH  - Adolescent
MH  - Cardiovascular Diseases/*complications/metabolism
MH  - Child
MH  - Diabetes Mellitus, Type 2/*complications/metabolism/physiopathology
MH  - Humans
MH  - Young Adult
OTO - NOTNLM
OT  - cardiovascular disease
OT  - clinical trials
OT  - diabete sucre de type 2
OT  - essais cliniques
OT  - jeunes
OT  - maladie cardiovasculaire
OT  - pathophysiologie
OT  - pathophysiology
OT  - type 2 diabetes mellitus
OT  - youth
EDAT- 2015/01/30 06:00
MHDA- 2015/01/30 06:01
CRDT- 2015/01/29 06:00
PHST- 2015/01/29 06:00 [entrez]
PHST- 2015/01/30 06:00 [pubmed]
PHST- 2015/01/30 06:01 [medline]
AID - 10.1139/bcb-2014-0118 [doi]
PST - ppublish
SO  - Biochem Cell Biol. 2015 Oct;93(5):496-510. doi: 10.1139/bcb-2014-0118. Epub 2014 
      Dec 7.