PMID- 25629520
OWN - NLM
STAT- MEDLINE
DCOM- 20151007
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 1
DP  - 2015
TI  - Evaluation of the effects of quercetin on damaged salivary secretion.
PG  - e0116008
LID - 10.1371/journal.pone.0116008 [doi]
LID - e0116008
AB  - With the aim of discovering an effective method to treat dry mouth, we analyzed 
      the effects of quercetin on salivary secretion and its mechanism of action. We 
      created a mouse model with impaired salivary secretion by exposure to radiation 
      and found that impaired secretion is suppressed by quercetin intake. Moreover, 
      secretion levels were enhanced in quercetin-fed normal mice. To elucidate the 
      mechanisms of these effects on salivary secretion, we conducted an analysis using 
      mouse submandibular gland tissues, a human salivary gland epithelial cell line 
      (HSY), and mouse aortic endothelial cells (MAECs). The results showed that 
      quercetin augments aquaporin 5 (AQP5) expression and calcium uptake, and 
      suppresses oxidative stress and inflammatory responses induced by radiation 
      exposure, suggesting that quercetin intake may be an effective method to treat 
      impaired salivary secretion.
FAU - Takahashi, Ayako
AU  - Takahashi A
AD  - Department of Pathology, Tsurumi University School of Dental Medicine, Yokohama, 
      Japan.
FAU - Inoue, Hiroko
AU  - Inoue H
AD  - Department of Pathology, Tsurumi University School of Dental Medicine, Yokohama, 
      Japan; Department of Pharmaceutical Sciences, Nihon Pharmaceutical University, 
      Saitama, Japan.
FAU - Mishima, Kenji
AU  - Mishima K
AD  - Division of Pathology, Department of Oral Diagnostic Sciences, School of 
      Dentistry, Showa University, Tokyo, Japan.
FAU - Ide, Fumio
AU  - Ide F
AD  - Department of Pathology, Tsurumi University School of Dental Medicine, Yokohama, 
      Japan.
FAU - Nakayama, Ryoko
AU  - Nakayama R
AD  - Department of Pathology, Tsurumi University School of Dental Medicine, Yokohama, 
      Japan.
FAU - Hasaka, Ayaka
AU  - Hasaka A
AD  - Department of Pathology, Tsurumi University School of Dental Medicine, Yokohama, 
      Japan.
FAU - Ryo, Koufuchi
AU  - Ryo K
AD  - Department of Pathology, Tsurumi University School of Dental Medicine, Yokohama, 
      Japan.
FAU - Ito, Yumi
AU  - Ito Y
AD  - Department of Pathology, Tsurumi University School of Dental Medicine, Yokohama, 
      Japan.
FAU - Sakurai, Takashi
AU  - Sakurai T
AD  - Department of Radiopraxis Science, Graduate School of Dentistry, Kanagawa Dental 
      University, Yokosuka, Japan.
FAU - Hasegawa, Yoshinori
AU  - Hasegawa Y
AD  - Department of Human Genome Research, Kazusa DNA Research Institute, Chiba, Japan.
FAU - Saito, Ichiro
AU  - Saito I
AD  - Department of Pathology, Tsurumi University School of Dental Medicine, Yokohama, 
      Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150128
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Antioxidants)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 9IKM0I5T1E (Quercetin)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type III)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Calcium/metabolism
MH  - Cytokines/genetics/metabolism
MH  - Disease Models, Animal
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation/drug effects
MH  - Gene Regulatory Networks
MH  - Inflammation Mediators/metabolism
MH  - Intracellular Space/metabolism
MH  - Male
MH  - Mice
MH  - Nitric Oxide Synthase Type III/genetics/metabolism
MH  - Quercetin/*pharmacology
MH  - Radiation Injuries, Experimental
MH  - Saliva
MH  - Salivary Glands/*drug effects/*metabolism/pathology/radiation effects
MH  - Salivation/*drug effects/genetics
PMC - PMC4309588
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/01/30 06:00
MHDA- 2015/10/08 06:00
PMCR- 2015/01/28
CRDT- 2015/01/29 06:00
PHST- 2014/09/29 00:00 [received]
PHST- 2014/12/03 00:00 [accepted]
PHST- 2015/01/29 06:00 [entrez]
PHST- 2015/01/30 06:00 [pubmed]
PHST- 2015/10/08 06:00 [medline]
PHST- 2015/01/28 00:00 [pmc-release]
AID - PONE-D-14-40763 [pii]
AID - 10.1371/journal.pone.0116008 [doi]
PST - epublish
SO  - PLoS One. 2015 Jan 28;10(1):e0116008. doi: 10.1371/journal.pone.0116008. 
      eCollection 2015.