PMID- 25630453
OWN - NLM
STAT- MEDLINE
DCOM- 20150817
LR  - 20220410
IS  - 1743-6109 (Electronic)
IS  - 1743-6095 (Linking)
VI  - 12
IP  - 3
DP  - 2015 Mar
TI  - Postorgasmic illness syndrome (POIS) in a Chinese man: no proof for IgE-mediated 
      allergy to semen.
PG  - 840-5
LID - 10.1111/jsm.12813 [doi]
AB  - INTRODUCTION: Postorgasmic illness syndrome (POIS) is a rarely described syndrome 
      characterized by transient flu-like symptoms and cognition disorders. Recent 
      studies suggest that immunogenic reactivity to autologous semen is the underlying 
      mechanism in POIS. However, there are no data published on immunoglobulin E 
      (IgE)-mediated allergy to autologous semen in men without POIS. AIM: The purpose 
      of the current work was to characterize the first diagnosed POIS patient in China 
      and to study the allergic response of autologous semen in the affected patient 
      and in three healthy males. METHODS: Specific IgE was tested with seminal fluid 
      and common perennial aeroallergens in vitro. Skin prick tests and intracutaneous 
      tests with autologous diluted semen were performed in the patient and three 
      healthy donors. The pattern of IgE reactivity to patient's semen was identified 
      using immunoblotting and ELISA. MAIN OUTCOME MEASURE: Clinical features of POIS, 
      skin reactions with autologous diluted seminal fluid, and the IgE reactivity 
      patterns of immunoblotting and ELISA in vitro. RESULTS: A patient was diagnosed 
      with POIS. The patient complained of lifelong premature ejaculation symptoms and 
      allergic rhinitis. Routine laboratory and hormonal assessments were generally 
      within normal range. The patient had a positive skin test with his own semen. 
      Three healthy donors also showed positive skin tests. No semen-specific IgE to 
      autologous semen was detected in the serum of the affected patient or healthy 
      males. CONCLUSIONS: This is the first report of a man with POIS in China. He had 
      positive skin reactions after injection of autologous seminal fluid but no 
      detectable serum concentrations of specific IgE antibodies. IgE-mediated semen 
      allergy in men may not be the potential mechanism of POIS.
CI  - (c) 2015 International Society for Sexual Medicine.
FAU - Jiang, Nannan
AU  - Jiang N
AD  - Department of Allergy, Peking Union Medical College Hospital, Beijing, China.
FAU - Xi, Guangpeng
AU  - Xi G
FAU - Li, Hongjun
AU  - Li H
FAU - Yin, Jia
AU  - Yin J
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20150129
PL  - Netherlands
TA  - J Sex Med
JT  - The journal of sexual medicine
JID - 101230693
RN  - 0 (Allergens)
RN  - 0 (Autoantigens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/chemistry/*immunology
MH  - Autoantigens/*immunology
MH  - China
MH  - Ejaculation
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Humans
MH  - Hypersensitivity/etiology/*immunology
MH  - Immunoblotting
MH  - Immunoglobulin E/*immunology
MH  - Male
MH  - Middle Aged
MH  - Quality of Life
MH  - Semen/chemistry/*immunology
MH  - Skin Tests/*methods
MH  - Syndrome
OTO - NOTNLM
OT  - Autologous Immunoreactions
OT  - Chemical Imbalances
OT  - Postorgasmic Illness Syndrome (POIS)
OT  - Seminal Fluid
EDAT- 2015/01/30 06:00
MHDA- 2015/08/19 06:00
CRDT- 2015/01/30 06:00
PHST- 2015/01/30 06:00 [entrez]
PHST- 2015/01/30 06:00 [pubmed]
PHST- 2015/08/19 06:00 [medline]
AID - S1743-6095(15)30963-2 [pii]
AID - 10.1111/jsm.12813 [doi]
PST - ppublish
SO  - J Sex Med. 2015 Mar;12(3):840-5. doi: 10.1111/jsm.12813. Epub 2015 Jan 29.