PMID- 25631251
OWN - NLM
STAT- MEDLINE
DCOM- 20160502
LR  - 20220410
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Print)
IS  - 0378-1135 (Linking)
VI  - 176
IP  - 1-2
DP  - 2015 Mar 23
TI  - Porcine circovirus type 2 (PCV2) enteric disease: an independent condition or 
      part of the systemic disease?
PG  - 83-7
LID - S0378-1135(15)00008-5 [pii]
LID - 10.1016/j.vetmic.2015.01.006 [doi]
AB  - Intestinal disorders in growing and finishing pigs have been associated with 
      several infectious agents, including Porcine circovirus type 2 (PCV2). This virus 
      has been mainly related with PCV2-systemic disease (PCV2-SD); nevertheless, some 
      authors have suggested a possible restricted intestinal infection of this virus 
      associated with enteric clinical signs. This condition has been referred as 
      PCV2-enteric disease (PCV2-ED). The present study analysed retrospectively, from 
      a pathological point of view, the relation between intestinal disorders and PCV2 
      infection in nursery and growing-finishing pigs. Among the 96 selected pigs 
      suffering from enteric disease and submitted for necropsy between 1998 and 2011, 
      the most prevalent enteric lesions were catarrhal enteritis/colitis (77.1%), 
      followed by fibrinous lesions (11.5%), granulomatous inflammation (4.2%) and 
      other lesions such as haemorrhages or ulceration (4.2%). Seventy-two pigs (75%) 
      were positive for PCV2 by in situ hybridization (ISH). Among positive pigs for 
      PCV2 ISH, 39 animals suffered from PCV2-SD and 33 had no lymphoid lesions but low 
      amount of viral nucleic acid in several lymphoid tissues, therefore, these 
      animals did not qualify for PCVD-ED. In conclusion, all animals with enteric 
      disorders that were positive to PCV2 by ISH had evidence of viral systemic 
      infection. These results suggest that PCV2-ED is probably a negligible condition 
      and PCV2 mainly contributes to enteric clinical disorders in relation to PCV2-SD 
      occurrence.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Baro, J
AU  - Baro J
AD  - Servei de Diagnostic de Patologia Veterinaria (SDPV), Departament de Sanitat i 
      Anatomia Animals, Facultat de Veterinaria, Universitat Autonoma de Barcelona, 
      Bellaterra, 08193 Barcelona, Spain.
FAU - Segales, J
AU  - Segales J
AD  - Servei de Diagnostic de Patologia Veterinaria (SDPV), Departament de Sanitat i 
      Anatomia Animals, Facultat de Veterinaria, Universitat Autonoma de Barcelona, 
      Bellaterra, 08193 Barcelona, Spain; Centre de Recerca en Sanitat Animal (CReSA), 
      UAB-IRTA, Campus de la Universitat Autonoma de Barcelona, Bellaterra (Cerdanyola 
      del Valles), 08193 Barcelona, Spain.
FAU - Martinez, J
AU  - Martinez J
AD  - Servei de Diagnostic de Patologia Veterinaria (SDPV), Departament de Sanitat i 
      Anatomia Animals, Facultat de Veterinaria, Universitat Autonoma de Barcelona, 
      Bellaterra, 08193 Barcelona, Spain; Centre de Recerca en Sanitat Animal (CReSA), 
      UAB-IRTA, Campus de la Universitat Autonoma de Barcelona, Bellaterra (Cerdanyola 
      del Valles), 08193 Barcelona, Spain. Electronic address: 
      jorge.martinez.martinez@uab.cat.
LA  - eng
PT  - Journal Article
DEP - 20150115
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
SB  - IM
MH  - Animals
MH  - Circoviridae Infections/pathology/*veterinary/virology
MH  - Circovirus/*isolation & purification
MH  - Immunohistochemistry/veterinary
MH  - In Situ Hybridization/veterinary
MH  - Intestines/virology
MH  - Lymphoid Tissue/pathology
MH  - Retrospective Studies
MH  - Swine
MH  - Swine Diseases/*pathology/virology
PMC - PMC7172167
OTO - NOTNLM
OT  - Diarrhoea
OT  - Intestine
OT  - PCV2-systemic disease
OT  - Porcine circovirus type 2 (PCV2)
OT  - Swine
EDAT- 2015/01/30 06:00
MHDA- 2016/05/03 06:00
PMCR- 2015/01/15
CRDT- 2015/01/30 06:00
PHST- 2014/09/28 00:00 [received]
PHST- 2014/12/29 00:00 [revised]
PHST- 2015/01/05 00:00 [accepted]
PHST- 2015/01/30 06:00 [entrez]
PHST- 2015/01/30 06:00 [pubmed]
PHST- 2016/05/03 06:00 [medline]
PHST- 2015/01/15 00:00 [pmc-release]
AID - S0378-1135(15)00008-5 [pii]
AID - 10.1016/j.vetmic.2015.01.006 [doi]
PST - ppublish
SO  - Vet Microbiol. 2015 Mar 23;176(1-2):83-7. doi: 10.1016/j.vetmic.2015.01.006. Epub 
      2015 Jan 15.