PMID- 25631844
OWN - NLM
STAT- MEDLINE
DCOM- 20151112
LR  - 20240109
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 253
IP  - 6
DP  - 2015 Jun
TI  - Spectral-domain optical coherence tomographic features of choroidal neovascular 
      membranes in multifocal choroiditis and punctate inner choroidopathy.
PG  - 949-57
LID - 10.1007/s00417-015-2930-5 [doi]
AB  - PURPOSE: To describe the spectral-domain optical coherence tomographic (SD-OCT) 
      features of inflammatory choroidal neovascular membranes (iCNV) in multifocal 
      choroiditis and punctate inner choroidopathy, and to compare them to those of the 
      acute inflammatory lesions in the same underlying diseases. This is a 
      retrospective, consecutive, observational case series. METHODS: Each patient 
      underwent a comprehensive eye examination, fundus photography, and fluorescein 
      angiography (FA) on the initial visit. SD-OCT features of iCNV were reviewed at 
      presentation and 4 weeks later, and were compared to SD-OCT features of the 
      inflammatory lesions. There were ten eyes with iCNV and eight eyes with the acute 
      lesions of chorioretinitis. RESULTS: All iCNV had a sub-retinal pigment 
      epithelium (sub-RPE) component and a subretinal or retinal component that 
      infiltrated the outer retinal layers to different extents. All iCNV had 
      associated fluid exudation, and all showed RPE and inner segment/outer segment 
      junction layer (IS/OS) disruption. On the other hand, approximately half of the 
      inflammatory lesions were confined between Bruch's membrane and RPE; the rest 
      showed infiltration into the outer retinal layers in a pattern similar to iCNV, 
      with no fluid exudation but with associated choroidal hyperreflectivity. In most 
      of them, disruption of RPE and IS/OS was also noted. CONCLUSIONS: The acute 
      lesions of chorioretinitis can be difficult to distinguish from iCNV based on 
      clinical examination and FA. However, iCNV demonstrate characteristic SD-OCT 
      features not seen with the inflammatory lesions. These findings may help to 
      differentiate these two entities that typically require different treatments.
FAU - Amer, Radgonde
AU  - Amer R
AD  - Department of Ophthalmology, Hadassah Medical Center, Jerusalem, Israel, 
      radgonde@gmail.com.
FAU - Priel, Ethan
AU  - Priel E
FAU - Kramer, Michal
AU  - Kramer M
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20150129
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
RN  - 0 (Angiogenesis Inhibitors)
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 0 (Glucocorticoids)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 2S9ZZM9Q9V (Bevacizumab)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Angiogenesis Inhibitors/therapeutic use
MH  - Antibodies, Monoclonal, Humanized/therapeutic use
MH  - Bevacizumab
MH  - Child
MH  - Chorioretinitis/complications/*diagnosis/drug therapy
MH  - Choroidal Neovascularization/*diagnosis/drug therapy/etiology
MH  - Choroiditis/complications/*diagnosis/drug therapy
MH  - Female
MH  - Fluorescein Angiography
MH  - Glucocorticoids/therapeutic use
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Male
MH  - Multifocal Choroiditis
MH  - Retrospective Studies
MH  - *Tomography, Optical Coherence
MH  - Vascular Endothelial Growth Factor A/antagonists & inhibitors
MH  - Visual Acuity
MH  - Young Adult
EDAT- 2015/01/30 06:00
MHDA- 2015/11/13 06:00
CRDT- 2015/01/30 06:00
PHST- 2014/09/19 00:00 [received]
PHST- 2015/01/07 00:00 [accepted]
PHST- 2015/01/05 00:00 [revised]
PHST- 2015/01/30 06:00 [entrez]
PHST- 2015/01/30 06:00 [pubmed]
PHST- 2015/11/13 06:00 [medline]
AID - 10.1007/s00417-015-2930-5 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2015 Jun;253(6):949-57. doi: 
      10.1007/s00417-015-2930-5. Epub 2015 Jan 29.