PMID- 25633453
OWN - NLM
STAT- MEDLINE
DCOM- 20150915
LR  - 20151119
IS  - 1117-1936 (Print)
VI  - 21
IP  - 4
DP  - 2014 Dec
TI  - Patient reporting practices of suspected adverse drug reactions to antiretroviral 
      drugs in a tertiary health facility in Nigeria.
PG  - 331-7
AB  - AIMS AND OBJECTIVES: To assess the proportion of patients with suspected adverse 
      drug reactions (ADRs) to highly active antiretroviral therapy (HAART) who 
      reported the reactions to their healthcare providers and the factors associated 
      with the reporting. PATIENTS AND METHODS: The study was conducted in the US 
      President's Emergency Plan For AIDS Relief (PEPFAR) clinic at the University of 
      Benin Teaching Hospital (UBTH), Benin City. The study population consisted of 
      adult HIV infection patients receiving HAART at the clinic, who had suspected 
      ADRs (SADRs). Using a systematic random sampling technique, patients were 
      selected and interviewed with the aid of a structured questionnaire. The outcome 
      measure was whether or not a SADR was reported to a healthcare provider. RESULTS: 
      The study participants totalled 233, 171 (73.4%) of whom reported SADRs to their 
      healthcare providers. Statistically significant difference was demonstrated with 
      following higher-than-mean proportions of participants that reported SADRs: 100% 
      (13/13) of respondents who experienced a SADR perceived to be life-threatening, 
      (p=0.02; OR=0.00, 95%CI=0.00-0.87); 88.6% (31/35) of those who regarded their 
      SADRs as severe (p=0.01; OR=4.02, 95%CI=1.28-16.63); and 95.2% (20/21) of those 
      who had skin eruptions (p=0.02; OR=0.12, 95%CI=0.00-0.81). CONCLUSIONS: The 
      finding that a high proportion of patients reported SADRs suggests that majority 
      of patients contribute to pharmacovigilance and that they constitute 
      opportunities for direct reporting of HAART-related ADRs to pharmacovilance 
      centres. Facility-based pharmacovigilance desks should be set up and access 
      should be created for patients to report SADRs directly. Healthcare providers 
      should educate patients to report SADRs.
FAU - Balogun, S H
AU  - Balogun SH
AD  - Department of Community Health, University of Benin Teaching Hospital, Benin 
      City, Nigeria.
FAU - Adeleye, O A
AU  - Adeleye OA
LA  - eng
PT  - Journal Article
PL  - Nigeria
TA  - Niger Postgrad Med J
JT  - The Nigerian postgraduate medical journal
JID - 9613595
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antiretroviral Therapy, Highly Active/*adverse effects
MH  - Drug-Related Side Effects and Adverse Reactions/*epidemiology
MH  - Female
MH  - HIV Infections/*drug therapy
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Nigeria/epidemiology
MH  - Surveys and Questionnaires
MH  - Tertiary Care Centers/*statistics & numerical data
MH  - Young Adult
EDAT- 2015/01/31 06:00
MHDA- 2015/09/16 06:00
CRDT- 2015/01/31 06:00
PHST- 2015/01/31 06:00 [entrez]
PHST- 2015/01/31 06:00 [pubmed]
PHST- 2015/09/16 06:00 [medline]
PST - ppublish
SO  - Niger Postgrad Med J. 2014 Dec;21(4):331-7.