PMID- 25633778
OWN - NLM
STAT- MEDLINE
DCOM- 20160212
LR  - 20181113
IS  - 1865-3774 (Electronic)
IS  - 0925-5710 (Linking)
VI  - 101
IP  - 6
DP  - 2015 Jun
TI  - PAX5-positive plasma cell myeloma with t(9;14;11)(p13;q32;q13), a novel complex 
      variant translocation of t(11;14)(q13;q32) and t(9;14)(p13;q32).
PG  - 608-11
LID - 10.1007/s12185-015-1749-5 [doi]
AB  - We describe herein the case of a 64-year-old man with a diagnosis of plasma cell 
      myeloma (PCM). A chromosome analysis based on G-banding and spectral karyotyping 
      revealed the following complex karyotype: 46,XY,del(3)(p?), 
      t(4;15)(q31;q24),t(9;14;11)(p13;q32;q13),add(15)(q24),add(18)(q21). Fluorescence 
      in situ hybridization (FISH) detected one signal each for the immunoglobulin 
      heavy chain (IGH) and cyclin D1 (CCND1) genes, and three fusion signals of IGH 
      and CCND1. FISH analysis of metaphase spreads revealed fusion signals on the 
      derivative chromosomes 9, 11, and 14. Immunohistochemical analysis identified 
      abnormal expression of CCND1 and PAX5. PAX5-positive PCM is rare because the 
      down-regulation of PAX5 is essential for the terminal differentiation of B cells 
      into plasma cells. To the best of our knowledge, this is the first reported case 
      of a novel complex variant translocation of t(11;14)(q13;q32) and 
      t(9;14)(p13;q32).
FAU - Sato, Kazuyuki
AU  - Sato K
AD  - Division of Hematology and Oncology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, 
      Kanagawa, 216-8511, Japan.
FAU - Sakai, Hirotaka
AU  - Sakai H
FAU - Kato, Masayuki
AU  - Kato M
FAU - Nishio, Yuji
AU  - Nishio Y
FAU - Tsuruoka, Yuka
AU  - Tsuruoka Y
FAU - Uemura, Yu
AU  - Uemura Y
FAU - Yokoi, Satoshi
AU  - Yokoi S
FAU - Saito, Tasuku
AU  - Saito T
FAU - Matsunawa, Manabu
AU  - Matsunawa M
FAU - Suzuki, Yoshinori
AU  - Suzuki Y
FAU - Isobe, Yasushi
AU  - Isobe Y
FAU - Inoue, Yasuyuki
AU  - Inoue Y
FAU - Takahashi, Masatomo
AU  - Takahashi M
FAU - Miura, Ikuo
AU  - Miura I
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20150130
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
RN  - 0 (CCND1 protein, human)
RN  - 0 (Immunoglobulin Heavy Chains)
RN  - 0 (PAX5 Transcription Factor)
RN  - 0 (PAX5 protein, human)
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Chromosome Banding
MH  - Chromosomes, Human, Pair 11/genetics
MH  - Chromosomes, Human, Pair 14/genetics
MH  - Chromosomes, Human, Pair 9/genetics
MH  - Cyclin D1/genetics
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Immunoglobulin Heavy Chains/genetics
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Multiple Myeloma/*genetics/*pathology
MH  - PAX5 Transcription Factor/*analysis/genetics
MH  - Plasma Cells/metabolism/*pathology
MH  - *Translocation, Genetic
EDAT- 2015/01/31 06:00
MHDA- 2016/02/13 06:00
CRDT- 2015/01/31 06:00
PHST- 2014/09/26 00:00 [received]
PHST- 2015/01/21 00:00 [accepted]
PHST- 2015/01/20 00:00 [revised]
PHST- 2015/01/31 06:00 [entrez]
PHST- 2015/01/31 06:00 [pubmed]
PHST- 2016/02/13 06:00 [medline]
AID - 10.1007/s12185-015-1749-5 [doi]
PST - ppublish
SO  - Int J Hematol. 2015 Jun;101(6):608-11. doi: 10.1007/s12185-015-1749-5. Epub 2015 
      Jan 30.