PMID- 25634119
OWN - NLM
STAT- MEDLINE
DCOM- 20160310
LR  - 20220410
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 31 Suppl 1
DP  - 2015 Jun
TI  - Extracellular volume fraction in dilated cardiomyopathy patients without obvious 
      late gadolinium enhancement: comparison with healthy control subjects.
PG  - 115-22
LID - 10.1007/s10554-015-0595-0 [doi]
AB  - To evaluate whether the extracellular volume fraction (ECV) measured using 
      cardiac magnetic resonance (CMR) imaging can detect myocardial tissue changes in 
      dilated cardiomyopathy (DCM) without late gadolinium enhancement (LGE). Forty-one 
      DCM patients and 10 healthy volunteers underwent pre- and post-T1 mapping using a 
      modified Look-Locker Inversion recovery sequence, LGE, and cine MRI on a 3-T CMR 
      system. LGE-MR findings were used to divide DCM patients into two groups: Group A 
      had no apparent LGE, and Group B had LGE apparent in at least one segment. The 
      ECV of the left ventricle (LV) myocardium (16 segments) was calculated in the 
      short-axis view as follows: ECV = [(DeltaR1 of myocardium/DeltaR1 of LV blood pool)] x (1 
      - hematocrit), where R1 = 1/T1, DeltaR1 = post-contrast R1 - pre-contrast R1. The LV 
      ejection fraction (LVEF) was obtained from cine MRI images. The mean myocardial 
      ECV in LGE (-) segments in Group A + B was compared to that of controls. The mean 
      myocardial ECV in Group A was compared to that of LGE (-) segments in Group B. 
      The correlation between LV systolic function and the mean myocardial ECV of the 
      whole myocardium was evaluated in all groups. Among the 41 DCM patients, 22 were 
      in Group A, and 19 were in Group B. The mean ECV of DCM patents (n = 41, 568 
      segments, 30.7 % +/- 5.9) was significantly higher (P < 0.001) than that of the 
      control group (n = 10, 157 segments, 25.6 % +/- 3.2). The ECV was inversely related 
      to LVEF in Group A (r = -0.551, P = 0.008), Group B (r = -0.525, P = 0.021), and 
      Group A + B (r = -0.550, P < 0.001). The ECV measured by MRI could be a useful 
      parameter in evaluating diffuse myocardial changes in DCM patients.
FAU - Hong, Yoo Jin
AU  - Hong YJ
AD  - Department of Radiology, Research Institute of Radiological Science, Severance 
      Hospital, Yonsei University Medical Center, Seoul, South Korea.
FAU - Park, Chul Hwan
AU  - Park CH
FAU - Kim, Young Jin
AU  - Kim YJ
FAU - Hur, Jin
AU  - Hur J
FAU - Lee, Hye-Jeong
AU  - Lee HJ
FAU - Hong, Sae Rom
AU  - Hong SR
FAU - Suh, Young Joo
AU  - Suh YJ
FAU - Greiser, Andreas
AU  - Greiser A
FAU - Paek, Mun Young
AU  - Paek MY
FAU - Choi, Byoung Wook
AU  - Choi BW
FAU - Kim, Tae Hoon
AU  - Kim TH
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150130
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 1BJ477IO2L (gadobutrol)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiomyopathy, Dilated/*diagnosis/*pathology/physiopathology
MH  - Case-Control Studies
MH  - *Contrast Media
MH  - Feasibility Studies
MH  - Female
MH  - Fibrosis
MH  - Heart Ventricles/*pathology/physiopathology
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - *Organometallic Compounds
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Stroke Volume
MH  - Ventricular Function, Left
MH  - Young Adult
EDAT- 2015/01/31 06:00
MHDA- 2016/03/11 06:00
CRDT- 2015/01/31 06:00
PHST- 2015/01/02 00:00 [received]
PHST- 2015/01/14 00:00 [accepted]
PHST- 2015/01/31 06:00 [entrez]
PHST- 2015/01/31 06:00 [pubmed]
PHST- 2016/03/11 06:00 [medline]
AID - 10.1007/s10554-015-0595-0 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2015 Jun;31 Suppl 1:115-22. doi: 
      10.1007/s10554-015-0595-0. Epub 2015 Jan 30.