PMID- 25634127
OWN - NLM
STAT- MEDLINE
DCOM- 20150909
LR  - 20161125
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 852
DP  - 2015
TI  - Low-dose computer tomography as a screening tool for lung cancer in a high risk 
      population.
PG  - 31-7
LID - 10.1007/5584_2014_107 [doi]
AB  - The aim of the study was to evaluate the usefulness of low-dose computer 
      tomography as a screening tool for early stage lung cancer. The study was 
      performed in 332 individuals aged 55-70 who were asymptomatic, who had not 
      previously suffered from cancer, and who smoked at least ten packs of cigarettes 
      a year. Baseline and repeated LD-CT scans were performed. Pulmonary nodules were 
      classified according to the size and morphology, and the results were categorized 
      as negative (no nodules observed), semi-positive (nodules of 4 mm or smaller in 
      diameter) and positive (nodules 5 mm or larger). Based on the category of the 
      patient, either a repeat low-dose CT, a bronchoscopy with or without a biopsy, or 
      a PET-CT was performed. The baseline screening showed 59 positive results. 
      Eighteen patients were hospitalized and underwent bronchoscopy and biopsy. One of 
      these patients had Stage I non small cell lung carcinoma (NSCLC) and a lobectomy 
      was performed. Three patients had Stage IV NSCLC and were referred for 
      chemotherapy. We identified 103 semi-positive results. Only 25 of those patients 
      had a repeat scan because of noncompliance. We observed no significant growth of 
      diagnosed nodules in a semi-positive group. Low-dose CT can be used as a 
      screening tool for early stage lung cancer. A high percentage of false-positive 
      results are observed. There are difficulties in diagnosing nodules in patients 
      with post-tuberculosis changes. A high rate of noncompliance was noticed.
FAU - Nahorecki, A
AU  - Nahorecki A
AD  - Department of Internal Medicine and Pneumology, Fourth Military Teaching 
      Hospital, 5 Weigla St., 50-981, Wroclaw, Poland, a.nahorecki@gmail.com.
FAU - Chabowski, M
AU  - Chabowski M
FAU - Kuzniar, T
AU  - Kuzniar T
FAU - Kedzierski, B
AU  - Kedzierski B
FAU - Jazwiec, P
AU  - Jazwiec P
FAU - Szuba, A
AU  - Szuba A
FAU - Janczak, D
AU  - Janczak D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
SB  - IM
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/*diagnostic imaging/epidemiology/pathology
MH  - Early Detection of Cancer/*methods
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*diagnostic imaging/epidemiology/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Poland/epidemiology
MH  - Population Surveillance/methods
MH  - Radiation Dosage
MH  - Radiography, Thoracic
MH  - Risk Factors
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2015/01/31 06:00
MHDA- 2015/09/10 06:00
CRDT- 2015/01/31 06:00
PHST- 2015/01/31 06:00 [entrez]
PHST- 2015/01/31 06:00 [pubmed]
PHST- 2015/09/10 06:00 [medline]
AID - 10.1007/5584_2014_107 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2015;852:31-7. doi: 10.1007/5584_2014_107.