PMID- 25634247
OWN - NLM
STAT- MEDLINE
DCOM- 20150929
LR  - 20151119
IS  - 1520-6882 (Electronic)
IS  - 0003-2700 (Linking)
VI  - 87
IP  - 5
DP  - 2015 Mar 3
TI  - Detection and direct readout of drugs in human urine using dynamic 
      surface-enhanced Raman spectroscopy and support vector machines.
PG  - 2937-44
LID - 10.1021/acs.analchem.5b00137 [doi]
AB  - A new, novel, rapid method to detect and direct readout of drugs in human urine 
      has been developed using dynamic surface-enhanced Raman spectroscopy (D-SERS) 
      with portable Raman spectrometer on gold nanorods (GNRs) and a classification 
      algorithm called support vector machines (SVM). The high-performance GNRs can 
      generate gigantic enhancement and the SERS signals obtained using D-SERS on it 
      have high reproducibility. On the basis of this feature of D-SERS, we have 
      obtained SERS spectra of urine and urine containing methamphetamine (MAMP). SVM 
      model was built using these data for fast identified and visual results. This 
      general method was successfully applied to the detection of 3, 4-methylenedioxy 
      methamphetamine (MDMA) in human urine. To verify the accuracy of the model, drug 
      addicts' urine containing MAMP were detected and identified correctly and rapidly 
      with accuracy more than 90%. The detection results were displayed directly 
      without analysis of their SERS spectra manually. Compared with the conventional 
      method in lab, the method only needs a 2 muL sample volume and takes no more than 
      2 min on the portable Raman spectrometer. It is anticipated that this method will 
      enable rapid, convenient detection of drugs on site for the police.
FAU - Dong, Ronglu
AU  - Dong R
AD  - Institute of Intelligent Machines, Chinese Academy of Sciences , Hefei, 230031, 
      China.
FAU - Weng, Shizhuang
AU  - Weng S
FAU - Yang, Liangbao
AU  - Yang L
FAU - Liu, Jinhuai
AU  - Liu J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150210
PL  - United States
TA  - Anal Chem
JT  - Analytical chemistry
JID - 0370536
RN  - 0 (2-methyl-4-amino-5-(2-methyl-3-furylthiomethyl)pyrimdiine)
RN  - 0 (Pyrimidines)
RN  - 3M4G523W1G (Silver)
RN  - 7440-57-5 (Gold)
RN  - M43H21IO8R (Dimethylnitrosamine)
SB  - IM
MH  - Algorithms
MH  - Dimethylnitrosamine/*urine
MH  - Gold/chemistry
MH  - Humans
MH  - Metal Nanoparticles/*chemistry
MH  - Nanotubes
MH  - Pyrimidines/*urine
MH  - Silver/chemistry
MH  - Spectrum Analysis, Raman/*methods
MH  - *Support Vector Machine
MH  - Surface Plasmon Resonance
MH  - Surface Properties
EDAT- 2015/01/31 06:00
MHDA- 2015/09/30 06:00
CRDT- 2015/01/31 06:00
PHST- 2015/01/31 06:00 [entrez]
PHST- 2015/01/31 06:00 [pubmed]
PHST- 2015/09/30 06:00 [medline]
AID - 10.1021/acs.analchem.5b00137 [doi]
PST - ppublish
SO  - Anal Chem. 2015 Mar 3;87(5):2937-44. doi: 10.1021/acs.analchem.5b00137. Epub 2015 
      Feb 10.