PMID- 25634458
OWN - NLM
STAT- MEDLINE
DCOM- 20150312
LR  - 20221207
IS  - 0021-4884 (Print)
IS  - 0021-4884 (Linking)
VI  - 63
IP  - 10
DP  - 2014 Dec
TI  - [Evaluation of the allergenicity of beta-casein in Japanese children with cow milk 
      allergy by using the basophil activation test].
PG  - 1330-7
AB  - BACKGROUND: Among the casein components, alphas-casein (alphas-CAS) is considered the 
      major allergen in Japan, and there are very few reports on the allergenicity of 
      beta-casein (beta-CAS). In this study, we compared the allergenicity of beta-CAS with that 
      of alphas-CAS in Japanese children with cow milk allergy (CMA). METHOD: The 
      allergenicity of alphas-CAS and beta-CAS in 29 CMA patients and 11 control subjects was 
      assessed using the basophil activation test (BAT). The accuracy of the BAT to 
      distinguish the patients with CMA from the control subjects was estimated using a 
      receiver operating characteristic (ROC) analysis and was expressed as the area 
      under the curve (AUC). RESULTS: BAT results for CM were positive in 93.1% of the 
      CMA patients. The results of the beta-CAS-BAT and alphas-CAS-BAT were found to be 
      positive in 86.2% and 69.0% of the CMA patients, respectively, however, the 
      difference was not significant. The AUC for the beta-CAS-BAT was 0.893, which was 
      not significantly different from that for the alphas-CAS-BAT (0.859). CONCLUSIONS: 
      These results suggest that the allergenicities of beta-CAS and alphas-CAS are similar in 
      Japanese patients with CMA.
FAU - Ito, Yasunori
AU  - Ito Y
AD  - Department of Allergy and Clinical Immunology, Shizuoka Children's Hospital.
FAU - Shimomura, Masaki
AU  - Shimomura M
AD  - Department of Allergy and Clinical Immunology, Shizuoka Children's Hospital.
FAU - Tokunaga, Fumika
AU  - Tokunaga F
AD  - Department of Allergy and Clinical Immunology, Shizuoka Children's Hospital.
FAU - Meguro, Takaaki
AU  - Meguro T
AD  - Department of Allergy and Clinical Immunology, Shizuoka Children's Hospital.
FAU - Seto, Shiro
AU  - Seto S
AD  - Department of Allergy and Clinical Immunology, Shizuoka Children's Hospital.
FAU - Hashiguchi, Akihiko
AU  - Hashiguchi A
AD  - BML Inc.
FAU - Kimura, Mituaki
AU  - Kimura M
AD  - Department of Allergy and Clinical Immunology, Shizuoka Children's Hospital.
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Arerugi
JT  - Arerugi = [Allergy]
JID - 0241212
RN  - 0 (Allergens)
RN  - 0 (Caseins)
SB  - IM
MH  - Allergens/immunology
MH  - Animals
MH  - Asian People
MH  - Basophils/*immunology
MH  - Caseins/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Male
MH  - Milk/*immunology
MH  - Milk Hypersensitivity/*immunology
EDAT- 2015/01/31 06:00
MHDA- 2015/03/13 06:00
CRDT- 2015/01/31 06:00
PHST- 2014/04/24 00:00 [received]
PHST- 2014/09/17 00:00 [accepted]
PHST- 2015/01/31 06:00 [entrez]
PHST- 2015/01/31 06:00 [pubmed]
PHST- 2015/03/13 06:00 [medline]
AID - 063101330e [pii]
PST - ppublish
SO  - Arerugi. 2014 Dec;63(10):1330-7.