PMID- 25634532
OWN - NLM
STAT- MEDLINE
DCOM- 20150513
LR  - 20150316
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 159
IP  - 4
DP  - 2015 Apr
TI  - Ultra-wide-field fundus autofluorescence in multiple evanescent white dot 
      syndrome.
PG  - 698-706
LID - S0002-9394(15)00044-6 [pii]
LID - 10.1016/j.ajo.2015.01.015 [doi]
AB  - PURPOSE: To observe the progression of affected lesions using ultra-wide-field 
      fundus autofluorescence (FAF) in multiple evanescent white dot syndrome. DESIGN: 
      Retrospective, observational case series. METHODS: setting: Institutional. 
      PATIENT POPULATION: 14 eyes of 13 patients (mean age, 35.8 years) with acute 
      disease unilaterally. OBSERVATION PROCEDURES: Patients underwent ultra-wide-field 
      FAF, spectral-domain optical coherence tomography (SD OCT), multifocal 
      electroretinography (mfERG), and Goldmann or automated perimetry; the 
      best-corrected visual acuity (BCVA) and refractive error were measured. MAIN 
      OUTCOME MEASURE: Ability of ultra-wide-field FAF to detect lesions with greater 
      sensitivity compared with color fundus photography. RESULTS: Ultra-wide-field FAF 
      imaging enabled improved visualization of the affected lesions and showed that 
      the core lesion was in the posterior fundus involving the peripapillary retina 
      and posterior pole and surrounded by hyper-autofluorescent spots outside the 
      vascular arcade. The posterior lesions expanded rapidly and peripheral spots 
      spread farther peripherally and reached a maximal extent during the acute stage. 
      During follow-up, the peripheral hyper-autofluorescent spots resolved and then 
      hyper-autofluorescence of the posterior fundus gradually faded. SD OCT showed 
      diffuse disruption of the photoreceptor inner segment/outer segment junction 
      (IS/OS) in the posterior fundus during the acute stage. The correlation between 
      the IS/OS abnormality and hyper-autofluorescent areas was unclear. The disrupted 
      IS/OS was restored with normalization of the FAF. CONCLUSIONS: Ultra-wide-field 
      FAF showed that the lesions arise from the peripapillary retina and the posterior 
      pole and spread peripherally in a centrifugal manner during the acute stage. The 
      hyper-autofluorescent spots faded from the periphery in a centripetal manner.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Hashimoto, Hideaki
AU  - Hashimoto H
AD  - Department of Ophthalmology, Gunma University School of Medicine, Maebashi, 
      Gunma, Japan. Electronic address: hidehashi0111@gmail.com.
FAU - Kishi, Shoji
AU  - Kishi S
AD  - Department of Ophthalmology, Gunma University School of Medicine, Maebashi, 
      Gunma, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Observational Study
DEP - 20150126
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Optical Imaging
MH  - Retinal Diseases/*diagnosis
MH  - Retinal Photoreceptor Cell Inner Segment/*pathology
MH  - Retinal Photoreceptor Cell Outer Segment/*pathology
MH  - Retrospective Studies
MH  - Scotoma/diagnosis
MH  - Syndrome
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
MH  - Visual Field Tests
MH  - Visual Fields/physiology
EDAT- 2015/01/31 06:00
MHDA- 2015/05/15 06:00
CRDT- 2015/01/31 06:00
PHST- 2014/05/22 00:00 [received]
PHST- 2015/01/13 00:00 [revised]
PHST- 2015/01/14 00:00 [accepted]
PHST- 2015/01/31 06:00 [entrez]
PHST- 2015/01/31 06:00 [pubmed]
PHST- 2015/05/15 06:00 [medline]
AID - S0002-9394(15)00044-6 [pii]
AID - 10.1016/j.ajo.2015.01.015 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2015 Apr;159(4):698-706. doi: 10.1016/j.ajo.2015.01.015. Epub 
      2015 Jan 26.