PMID- 25634595
OWN - NLM
STAT- MEDLINE
DCOM- 20150406
LR  - 20150216
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 113
IP  - 4
DP  - 2015 Feb 28
TI  - Prevalence of hyperhomocysteinaemia and some of its major determinants in Shaanxi 
      Province, China: a cross-sectional study.
PG  - 691-8
LID - 10.1017/S0007114514004218 [doi]
AB  - The aim of the present study was to investigate the prevalence of 
      hyperhomocysteinaemia (HHCY; total plasma homocysteine (tHcy) concentration 
      >15 mumol/l) and its major determinants in healthy Chinese northerners. A 
      descriptive and cross-sectional study was conducted in Shaanxi Province, China. 
      The study sample included 2645 participants (1042 men and 1603 women) aged >20 
      years. Demographic characteristics and lifestyle factors were assessed via 
      questionnaire interviews and physical examination. Plasma levels of homocysteine 
      and folate and methylenetetrahydrofolate reductase (MTHFR) gene polymorphism were 
      determined according to standard methods. The prevalence of HHCY was 67.7 % 
      (81.4 % in men and 58.8 % in women). The geometric mean of tHcy concentration was 
      19.1 mumol/l. The OR of HHCY were 0.44 (95 % CI 0.34, 0.57) for women v. men; 1.95 
      (95 % CI 1.41, 2.70), 1.41 (95 % CI 1.05, 1.88) and 0.76 (95 % CI 0.64, 0.89) for 
      participants with smoking and alcohol drinking cessation and improved physical 
      activity levels, respectively; 0.25 (95 % CI 0.17, 0.38), 0.33 (95 % CI 0.22, 
      0.49) and 0.56 (95 % CI 0.36, 0.88) for participants with an education level of 
      elementary school, secondary school and university v. illiterate, respectively; 
      1.41 (95 % CI 1.13, 1.75) and 3.05 (95 % CI 2.35, 3.97) for participants with CT 
      and TT v. CC genotype at MTHFR 677C --> T polymorphism, respectively. These results 
      demonstrate that the prevalence of HHCY is considerably high in Chinese 
      northerners, especially in TT subjects, suggesting that implementation of 
      tHcy-lowering strategies, such as lifestyle changes, is necessary.
FAU - Liu, Xue-Dong
AU  - Liu XD
AD  - Department of Neurology,Xijing Hospital, The Fourth Military Medical 
      University,Changle Xi Road 17,Xi'an710032,Shaanxi Province,People's Republic of 
      China.
FAU - Gao, Bin
AU  - Gao B
AD  - Department of Endocrinology,Xijing Hospital, The Fourth Military Medical 
      University,Changle Xi Road 17,Xi'an710032,Shaanxi Province,People's Republic of 
      China.
FAU - Sun, Dong
AU  - Sun D
AD  - Department of Neurology,Xijing Hospital, The Fourth Military Medical 
      University,Changle Xi Road 17,Xi'an710032,Shaanxi Province,People's Republic of 
      China.
FAU - Shi, Ming
AU  - Shi M
AD  - Department of Neurology,Xijing Hospital, The Fourth Military Medical 
      University,Changle Xi Road 17,Xi'an710032,Shaanxi Province,People's Republic of 
      China.
FAU - Ma, Yue-Yun
AU  - Ma YY
AD  - Department of Clinical Laboratory,Xijing Hospital, The Fourth Military Medical 
      University,Xi'an,Shaanxi,People's Republic of China.
FAU - Liu, Zhi-Rong
AU  - Liu ZR
AD  - Department of Neurology,Xijing Hospital, The Fourth Military Medical 
      University,Changle Xi Road 17,Xi'an710032,Shaanxi Province,People's Republic of 
      China.
FAU - Wang, Bo
AU  - Wang B
AD  - Department of Epidemiology,School of Military Preventive Medicine, The Fourth 
      Military Medical University,Xi'an,Shaanxi,People's Republic of China.
FAU - Xu, Xiping
AU  - Xu X
AD  - Institute of Nephrology, Southern Medical University,Guangzhou,Guangdong,People's 
      Republic of China.
FAU - Xu, Xin
AU  - Xu X
AD  - Institute of Nephrology, Southern Medical University,Guangzhou,Guangdong,People's 
      Republic of China.
FAU - Ji, Qiu-He
AU  - Ji QH
AD  - Department of Endocrinology,Xijing Hospital, The Fourth Military Medical 
      University,Changle Xi Road 17,Xi'an710032,Shaanxi Province,People's Republic of 
      China.
FAU - Zhao, Gang
AU  - Zhao G
AD  - Department of Neurology,Xijing Hospital, The Fourth Military Medical 
      University,Changle Xi Road 17,Xi'an710032,Shaanxi Province,People's Republic of 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150130
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 935E97BOY8 (Folic Acid)
RN  - EC 1.5.1.20 (MTHFR protein, human)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - China/epidemiology
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Folic Acid/blood
MH  - Folic Acid Deficiency/blood/epidemiology
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Homocysteine/blood
MH  - Humans
MH  - Hyperhomocysteinemia/blood/*epidemiology/*genetics/metabolism
MH  - Male
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics/metabolism
MH  - Middle Aged
MH  - Nutrition Surveys
MH  - *Polymorphism, Genetic
MH  - Prevalence
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Chinese northerners
EDAT- 2015/01/31 06:00
MHDA- 2015/04/07 06:00
CRDT- 2015/01/31 06:00
PHST- 2015/01/31 06:00 [entrez]
PHST- 2015/01/31 06:00 [pubmed]
PHST- 2015/04/07 06:00 [medline]
AID - S0007114514004218 [pii]
AID - 10.1017/S0007114514004218 [doi]
PST - ppublish
SO  - Br J Nutr. 2015 Feb 28;113(4):691-8. doi: 10.1017/S0007114514004218. Epub 2015 
      Jan 30.