PMID- 25635986
OWN - NLM
STAT- MEDLINE
DCOM- 20150604
LR  - 20221207
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 19
IP  - 1
DP  - 2015 Jan
TI  - Single nucleotide polymorphisms on SHIP2 is associated with Type 2 diabetes 
      mellitus in Chinese Han population.
PG  - 129-37
LID - 8347 [pii]
AB  - OBJECTIVE: Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by 
      insulin resistance in the target tissue of insulin with insufficient insulin 
      secretion in pancreatic beta-cells. Src homology 2-containing 5'-inositol 
      phosphatase 2 (SHIP2) is a lipid phosphatase that hydrolyzes PI3-kinase product 
      PI(3,4,5)P3 to PI(3,4)P2, which contributes to the negative regulation of insulin 
      signaling both in vitro and in vivo. Some polymorphisms of SHIP2 have been 
      reported to be associated with the metabolic syndrome including T2DM and 
      hypertension in British, French and Japanese T2DM population. PATIENTS AND 
      METHODS: In our present study, we investigated the relation between single 
      nucleotide polymorphisms (SNPs) on SHIP2 gene and the pathogenesis of T2DM in 
      Chinese Han population. RESULTS AND CONCLUSIONS: Our results indicated that the 
      genotype and allele frequency of SHIP2 (+1893CC/AA) locus in T2DM patients showed 
      significantly different from between the healthy control population. In addition, 
      the G allele of SHIP2 (+2945A/G) seemed to increase the susceptibility to 
      hypertension for T2DM patients.
FAU - Hao, Y-M
AU  - Hao YM
AD  - Department of Endocrinology, the Second Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, People's Republic of China. lianfu@163.com.
FAU - Liu, Q-J
AU  - Liu QJ
FAU - Wang, R-Y
AU  - Wang RY
FAU - Cao, Y-P
AU  - Cao YP
FAU - Zhang, Y
AU  - Zhang Y
FAU - Zuo, L-F
AU  - Zuo LF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - EC 3.1.3.2 (Phosphoric Monoester Hydrolases)
RN  - EC 3.1.3.86 (INPPL1 protein, human)
RN  - EC 3.1.3.86 (Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases)
SB  - IM
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/blood/ethnology/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
MH  - Phosphoric Monoester Hydrolases/*genetics
MH  - Polymorphism, Single Nucleotide
MH  - Signal Transduction
EDAT- 2015/01/31 06:00
MHDA- 2015/06/05 06:00
CRDT- 2015/01/31 06:00
PHST- 2015/01/31 06:00 [entrez]
PHST- 2015/01/31 06:00 [pubmed]
PHST- 2015/06/05 06:00 [medline]
AID - 8347 [pii]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2015 Jan;19(1):129-37.