PMID- 25636149
OWN - NLM
STAT- MEDLINE
DCOM- 20160125
LR  - 20221207
IS  - 1932-751X (Electronic)
IS  - 1932-7501 (Print)
IS  - 1932-7501 (Linking)
VI  - 35
IP  - 3
DP  - 2015 May-Jun
TI  - Remission of recently diagnosed type 2 diabetes mellitus with weight loss and 
      exercise.
PG  - 193-7
LID - 10.1097/HCR.0000000000000106 [doi]
AB  - PURPOSE: To determine the rate of remission of recently diagnosed (<1 year) type 
      2 diabetes mellitus (T2DM) in overweight/obese individuals, with a 6-month 
      program of weight loss and exercise. METHODS: Subjects (N = 12) were 
      overweight/obese (body mass index = 35.8 +/- 4.3 kg/m), sedentary, and unfit 
      ((Equation is included in full-text article.)O2peak = 20.7 +/- 4.7 mL.kg.min) and 
      recently (<1 year) diagnosed with T2DM. They were willing to participate in a 
      lifestyle program of behavioral weight loss counseling and supervised exercise 
      located at a cardiac rehabilitation program prior to consideration of diabetes 
      medications. Glycated hemoglobin (HbA1c) level before and after the study 
      intervention was the primary study outcome, along with secondary metabolic, 
      fitness, and body composition variables. RESULTS: Subjects had a baseline HbA1c 
      of 6.5% to 8.0% (mean 6.8 +/- 0.2). Subjects lost 9.7 +/- 0.2 kg body weight (9%) and 
      improved peak aerobic capacity by 18%. Two subjects withdrew for medical reasons 
      unrelated to the lifestyle program. Eight of 10 completers (80%) went into 
      partial T2DM remission, with the mean HbA1c decreasing from 6.8 +/- 0.2% to 6.2 +/- 
      0.3% (P < .001). CONCLUSIONS: For individuals with recently diagnosed T2DM 
      willing to undertake a formal lifestyle program, 80% of study completers and 67% 
      of our total population achieved at least a partial T2DM remission at 6 months. 
      Further study of this intervention at the time of diagnosis of T2DM with 
      randomized controls and longer-term followup is warranted.
FAU - Ades, Philip A
AU  - Ades PA
AD  - Divisions of Cardiology (Dr Ades and Mr Savage), Endocrinology (Dr Marney), and 
      Nutrition and Food Sciences (Dr Harvey and Ms Evans), University of Vermont 
      Medical Center, Burlington, Vermont.
FAU - Savage, Patrick D
AU  - Savage PD
FAU - Marney, Annis M
AU  - Marney AM
FAU - Harvey, Jean
AU  - Harvey J
FAU - Evans, Kimberly A
AU  - Evans KA
LA  - eng
GR  - P20 GM103644/GM/NIGMS NIH HHS/United States
GR  - P20GM103644-01/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cardiopulm Rehabil Prev
JT  - Journal of cardiopulmonary rehabilitation and prevention
JID - 101291247
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Diabetes Mellitus, Type 2/blood/*complications/*therapy
MH  - *Diet, Reducing
MH  - *Exercise Therapy
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Health Promotion/methods
MH  - Humans
MH  - Life Style
MH  - Male
MH  - Middle Aged
MH  - Overweight/blood/*complications/*therapy
MH  - Weight Loss
PMC - PMC4409919
MID - NIHMS641879
EDAT- 2015/01/31 06:00
MHDA- 2016/01/26 06:00
PMCR- 2016/05/01
CRDT- 2015/01/31 06:00
PHST- 2015/01/31 06:00 [entrez]
PHST- 2015/01/31 06:00 [pubmed]
PHST- 2016/01/26 06:00 [medline]
PHST- 2016/05/01 00:00 [pmc-release]
AID - 10.1097/HCR.0000000000000106 [doi]
PST - ppublish
SO  - J Cardiopulm Rehabil Prev. 2015 May-Jun;35(3):193-7. doi: 
      10.1097/HCR.0000000000000106.