PMID- 25636602
OWN - NLM
STAT- MEDLINE
DCOM- 20160115
LR  - 20150321
IS  - 1873-5177 (Electronic)
IS  - 0091-3057 (Linking)
VI  - 131
DP  - 2015 Apr
TI  - The effect of a selective neuronal nitric oxide synthase inhibitor 3-bromo 
      7-nitroindazole on spatial learning and memory in rats.
PG  - 19-25
LID - S0091-3057(15)00024-6 [pii]
LID - 10.1016/j.pbb.2015.01.013 [doi]
AB  - Since the discovery of nitric oxide (NO) as a neuronal messenger, its way to 
      modulate learning and memory functions is subject of intense research. NO is an 
      intercellular messenger in the central nervous system and is formed on demand 
      through the conversion of L-arginine to L-citrulline via the enzyme nitric oxide 
      synthase (NOS). Neuronal form of nitric oxide synthase may play an important role 
      in a wide range of physiological and pathological conditions. Therefore the aim 
      of this study was to investigate the effects of chronic 3-bromo 7-nitroindazole 
      (3-Br 7-NI), specific neuronal nitric oxide synthase (nNOS) inhibitor, 
      administration on spatial learning and memory performance in rats using the 
      Morris water maze (MWM) paradigm. Male rats received either 3-Br 7-NI 
      (20mg/kg/day) or saline via intraperitoneal injection for 5days. Daily 
      administration of the specific neuronal nitric oxide synthase (nNOS) inhibitor, 
      3-Br 7-NI impaired the acquisition of the MWM task. 3-Br 7-NI also impaired the 
      probe trial. The MWM training was associated with a significant increase in the 
      brain-derived neurotrophic factor (BDNF) mRNA expression in the hippocampus. BDNF 
      mRNA expression in the hippocampus did not change after 3-Br 7-NI treatment. 
      L-arginine significantly reversed behavioural parameters, and the effect of 3-Br 
      7-NI was found to be NO-dependent. There were no differences in locomotor 
      activity and blood pressure in 3-Br 7-NI treated rats. Our results may suggest 
      that nNOS plays a key role in spatial memory formation in rats.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Gocmez, Semil Selcen
AU  - Gocmez SS
AD  - Namik Kemal University, Faculty of Medicine, Department of Pharmacology, 59030 
      Tekirdag, Turkey. Electronic address: selcengmez@yahoo.com.
FAU - Yazir, Yusufhan
AU  - Yazir Y
AD  - Kocaeli University, Faculty of Medicine, Department of Histology and Embryology, 
      Umuttepe 41380, Kocaeli, Turkey. Electronic address: yusufhanyazir@yahoo.com.
FAU - Sahin, Deniz
AU  - Sahin D
AD  - Kocaeli University, Faculty of Medicine, Department of Physiology, Umuttepe 
      41380, Kocaeli, Turkey. Electronic address: sahindeniztr@yahoo.com.
FAU - Karadenizli, Sabriye
AU  - Karadenizli S
AD  - Kocaeli University, Faculty of Medicine, Department of Physiology, Umuttepe 
      41380, Kocaeli, Turkey. Electronic address: sabriyekaradenizli@gmail.com.
FAU - Utkan, Tijen
AU  - Utkan T
AD  - Kocaeli University, Faculty of Medicine, Department of Pharmacology and 
      Experimental Medical Research and Application Unit, Umuttepe 41380, Kocaeli, 
      Turkey. Electronic address: tijenutkan@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150128
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (3-bromo-7-nitroindazole)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Indazoles)
RN  - 94ZLA3W45F (Arginine)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type I)
SB  - IM
MH  - Animals
MH  - Arginine/pharmacology
MH  - Brain-Derived Neurotrophic Factor/analysis/biosynthesis
MH  - Hippocampus/chemistry/drug effects
MH  - Indazoles/antagonists & inhibitors/*pharmacology
MH  - Male
MH  - Memory/*drug effects
MH  - Nitric Oxide Synthase Type I/*antagonists & inhibitors
MH  - Rats
MH  - Rats, Wistar
MH  - Spatial Learning/*drug effects
OTO - NOTNLM
OT  - 3-Br 7-NI
OT  - Morris water maze
OT  - Nitric oxide
OT  - Spatial memory
EDAT- 2015/02/01 06:00
MHDA- 2016/01/16 06:00
CRDT- 2015/02/01 06:00
PHST- 2013/03/03 00:00 [received]
PHST- 2015/01/15 00:00 [revised]
PHST- 2015/01/20 00:00 [accepted]
PHST- 2015/02/01 06:00 [entrez]
PHST- 2015/02/01 06:00 [pubmed]
PHST- 2016/01/16 06:00 [medline]
AID - S0091-3057(15)00024-6 [pii]
AID - 10.1016/j.pbb.2015.01.013 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2015 Apr;131:19-25. doi: 10.1016/j.pbb.2015.01.013. Epub 
      2015 Jan 28.