PMID- 25636994
OWN - NLM
STAT- MEDLINE
DCOM- 20160104
LR  - 20160526
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 162
IP  - 1-3
DP  - 2015 Mar
TI  - Factors contributing to the duration of untreated prodromal positive symptoms in 
      individuals at ultra-high risk for psychosis.
PG  - 64-6
LID - S0920-9964(15)00017-1 [pii]
LID - 10.1016/j.schres.2015.01.013 [doi]
AB  - Individuals at ultra-high risk (UHR) for psychosis experience a considerable 
      delay before appropriate clinical attention is provided. Therefore, we 
      investigated the correlates of this delay by examining clinical, 
      socio-demographic and neuropsychological contributors to the duration of 
      untreated prodromal positive symptoms (DUPP) in them (n=73). The slowly 
      progressive mode of functional decline, defined as a small percentage drop in the 
      Global Assessment of Functioning (GAF) score within the past year, and male 
      gender, explained a considerable portion of the DUPP in the multivariate 
      regression model (F=9.269, p<0.001). Slower functional decline may be correlated 
      with delayed care during the UHR period.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Chon, Myong-Wuk
AU  - Chon MW
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 
      Republic of Korea; Department of Psychiatry, Seoul National University College of 
      Medicine, Seoul, Republic of Korea.
FAU - Lee, Tae Young
AU  - Lee TY
AD  - Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea.
FAU - Kim, Sung Nyun
AU  - Kim SN
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 
      Republic of Korea.
FAU - Huh, Min Jung
AU  - Huh MJ
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 
      Republic of Korea; Department of Psychiatry, Seoul National University College of 
      Medicine, Seoul, Republic of Korea.
FAU - Park, Hye Youn
AU  - Park HY
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Lee, Cho Rong
AU  - Lee CR
AD  - Department of Brain & Cognitive Sciences, Seoul National University College of 
      Natural Sciences, Seoul, Republic of Korea.
FAU - Shin, Na Young
AU  - Shin NY
AD  - Department of Brain & Cognitive Sciences, Seoul National University College of 
      Natural Sciences, Seoul, Republic of Korea.
FAU - Kwon, Jun Soo
AU  - Kwon JS
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 
      Republic of Korea; Department of Psychiatry, Seoul National University College of 
      Medicine, Seoul, Republic of Korea; Institute of Human Behavioral Medicine, 
      SNU-MRC, Seoul, Republic of Korea; Department of Brain & Cognitive Sciences, 
      Seoul National University College of Natural Sciences, Seoul, Republic of Korea. 
      Electronic address: kwonjs@snu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150128
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Models, Psychological
MH  - Multivariate Analysis
MH  - Neuropsychological Tests
MH  - *Prodromal Symptoms
MH  - Prospective Studies
MH  - Psychotic Disorders/epidemiology/*psychology/*therapy
MH  - Regression Analysis
MH  - Risk
MH  - Time-to-Treatment
MH  - Young Adult
OTO - NOTNLM
OT  - Delayed care
OT  - Duration of untreated prodromal positive symptoms
OT  - Functional decline
OT  - Psychosis
OT  - Ultra-high risk for psychosis
EDAT- 2015/02/01 06:00
MHDA- 2016/01/05 06:00
CRDT- 2015/02/01 06:00
PHST- 2014/09/11 00:00 [received]
PHST- 2014/12/26 00:00 [revised]
PHST- 2015/01/06 00:00 [accepted]
PHST- 2015/02/01 06:00 [entrez]
PHST- 2015/02/01 06:00 [pubmed]
PHST- 2016/01/05 06:00 [medline]
AID - S0920-9964(15)00017-1 [pii]
AID - 10.1016/j.schres.2015.01.013 [doi]
PST - ppublish
SO  - Schizophr Res. 2015 Mar;162(1-3):64-6. doi: 10.1016/j.schres.2015.01.013. Epub 
      2015 Jan 28.