PMID- 25637667
OWN - NLM
STAT- MEDLINE
DCOM- 20160114
LR  - 20150330
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 76
IP  - 4
DP  - 2015 Apr
TI  - Human leukocyte antigen (HLA)-G during pregnancy part II: associations between 
      maternal and fetal HLA-G genotypes and soluble HLA-G.
PG  - 260-71
LID - S0198-8859(15)00016-6 [pii]
LID - 10.1016/j.humimm.2015.01.015 [doi]
AB  - Human leukocyte antigen (HLA)-G is a class Ib molecule with restricted tissue 
      distribution expressed on the extra-villous trophoblast and seems to have 
      immunomodulatory functions during pregnancy. Studies have linked HLA-G 
      polymorphisms to pregnancy complications such as preeclampsia and recurrent 
      miscarriage. Levels of soluble HLA-G (sHLA-G) in blood plasma from non-pregnant 
      donors seem to be associated with these polymorphisms. In the current study, we 
      have genotyped 246 mothers and their offspring for HLA-G polymorphisms in the 
      3'-untranslated region (3'UTR) and measured sHLA-G in maternal blood plasma 
      samples from gestational week 20 and at term, as well as in fetal umbilical cord 
      blood samples. This is the first large study simultaneously performing HLA-G 
      genotyping of mother and offspring and measuring sHLA-G in both maternal and 
      umbilical cord blood. The results showed that increasing numbers of 14bp ins 
      (rs66554220) alleles in the mother-child genotype combinations were associated 
      with higher maternal sHLA-G levels at term when restricting the analysis to 14bp 
      ins/del heterozygous mothers (p=0.015). Furthermore, increasing numbers of 14InsG 
      haplotypes (14bp ins/del and +3142C/G (rs1063320) polymorphism) in mother-child 
      genotype combinations were associated with higher levels of sHLA-G at term in 
      heterozygous 14DelC/14InsG mothers (p=0.005). In conclusion, the results indicate 
      that there is an association between combined feto-maternal HLA-G genotypes and 
      sHLA-G levels in maternal blood plasma.
CI  - Copyright (c) 2015 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Dahl, Mette
AU  - Dahl M
AD  - Department of Clinical Biochemistry, Centre for Immune Regulation and 
      Reproductive Immunology (CIRRI), Copenhagen University Hospital (Roskilde) and 
      Roskilde Hospital, 7-13 Kogevej, DK-4000 Roskilde, Denmark.
FAU - Klitkou, Louise
AU  - Klitkou L
AD  - Department of Obstetrics and Gynecology, Aalborg University Hospital, 9000 
      Aalborg, Denmark.
FAU - Christiansen, Ole B
AU  - Christiansen OB
AD  - Department of Obstetrics and Gynecology, Aalborg University Hospital, 9000 
      Aalborg, Denmark; Fertility Clinic 4071, Rigshospitalet, Copenhagen University 
      Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
FAU - Djurisic, Snezana
AU  - Djurisic S
AD  - Department of Clinical Biochemistry, Centre for Immune Regulation and 
      Reproductive Immunology (CIRRI), Copenhagen University Hospital (Roskilde) and 
      Roskilde Hospital, 7-13 Kogevej, DK-4000 Roskilde, Denmark.
FAU - Piosik, Zofia Maria
AU  - Piosik ZM
AD  - Department of Obstetrics and Gynecology, Aalborg University Hospital, 9000 
      Aalborg, Denmark.
FAU - Skovbo, Peter
AU  - Skovbo P
AD  - Department of Obstetrics and Gynecology, Aalborg University Hospital, 9000 
      Aalborg, Denmark.
FAU - Moller, Anna Margrethe
AU  - Moller AM
AD  - Department of Obstetrics and Gynecology, Aalborg University Hospital, 9000 
      Aalborg, Denmark.
FAU - Steffensen, Rudi
AU  - Steffensen R
AD  - Department of Clinical Immunology, Aalborg University Hospital, 32 Urbansgade, 
      9000 Aalborg, Denmark.
FAU - Hviid, Thomas Vauvert F
AU  - Hviid TV
AD  - Department of Clinical Biochemistry, Centre for Immune Regulation and 
      Reproductive Immunology (CIRRI), Copenhagen University Hospital (Roskilde) and 
      Roskilde Hospital, 7-13 Kogevej, DK-4000 Roskilde, Denmark. Electronic address: 
      tvh@regionsjaelland.dk.
LA  - eng
PT  - Journal Article
DEP - 20150128
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (3' Untranslated Regions)
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - 3' Untranslated Regions/genetics
MH  - Abortion, Habitual/genetics/*immunology
MH  - Alleles
MH  - DNA Mutational Analysis
MH  - Female
MH  - Fetal Blood/*metabolism
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Gestational Age
MH  - HLA-G Antigens/blood/genetics/*immunology
MH  - Histocompatibility/genetics
MH  - Humans
MH  - Polymorphism, Genetic
MH  - Pre-Eclampsia/genetics/*immunology
MH  - Pregnancy
OTO - NOTNLM
OT  - HLA-G
OT  - MHC
OT  - Polymorphism
OT  - Pregnancy
OT  - sHLA-G
EDAT- 2015/02/01 06:00
MHDA- 2016/01/15 06:00
CRDT- 2015/02/01 06:00
PHST- 2014/07/16 00:00 [received]
PHST- 2014/12/21 00:00 [revised]
PHST- 2015/01/14 00:00 [accepted]
PHST- 2015/02/01 06:00 [entrez]
PHST- 2015/02/01 06:00 [pubmed]
PHST- 2016/01/15 06:00 [medline]
AID - S0198-8859(15)00016-6 [pii]
AID - 10.1016/j.humimm.2015.01.015 [doi]
PST - ppublish
SO  - Hum Immunol. 2015 Apr;76(4):260-71. doi: 10.1016/j.humimm.2015.01.015. Epub 2015 
      Jan 28.