PMID- 25638301
OWN - NLM
STAT- MEDLINE
DCOM- 20150427
LR  - 20220408
IS  - 1942-5546 (Electronic)
IS  - 0025-6196 (Linking)
VI  - 90
IP  - 3
DP  - 2015 Mar
TI  - Adverse in-hospital events are associated with increased in-hospital mortality 
      and length of stay in patients with or at risk of acute respiratory distress 
      syndrome.
PG  - 321-8
LID - S0025-6196(14)01138-0 [pii]
LID - 10.1016/j.mayocp.2014.12.015 [doi]
AB  - OBJECTIVE: To explore the effect of various adverse hospital events on short- and 
      long-term outcomes in a cohort of acutely ill hospitalized patients. PATIENTS AND 
      METHODS: In a secondary analysis of a retrospective cohort of acutely ill 
      hospitalized patients with sepsis, shock, or pneumonia or undergoing high-risk 
      surgery who were at risk for or had developed acute respiratory distress syndrome 
      between 2001 and 2010, the effects of potentially preventable hospital exposures 
      and adverse events (AEs) on in-hospital and intensive care unit (ICU) mortality, 
      length of stay, and long-term survival were analyzed. Adverse effects chosen for 
      inclusion were inadequate empiric antimicrobial coverage, hospital-acquired 
      aspiration, medical or surgical misadventure, inappropriate blood product 
      transfusion, and injurious tidal volume while on mechanical ventilation. RESULTS: 
      In 828 patients analyzed, the distribution of 0, 1, 2, and 3 or more cumulative 
      AEs was 521 (63%), 126 (15%), 135 (16%), and 46 (6%) patients, respectively. The 
      adjusted odds ratios (95% CI) for in-hospital mortality in patients who had 1, 2, 
      and 3 or more AEs were 0.9 (0.5-1.7), 0.9 (0.5-1.6), and 1.4 (0.6-3.3), 
      respectively. One AE increased the length of stay, difference between means (95% 
      CI), in the hospital by 8.7 (3.8-13.7) days and in the ICU by 2.4 (0.6-4.2) days. 
      CONCLUSION: Potentially preventable hospital exposure to AEs is associated with 
      prolonged ICU and hospital lengths of stay. Implementation of effective patient 
      safety interventions is of utmost priority in acute care hospitals.
CI  - Copyright (c) 2015 Mayo Foundation for Medical Education and Research. Published by 
      Elsevier Inc. All rights reserved.
FAU - Ahmed, Adil H
AU  - Ahmed AH
AD  - Multidisciplinary Epidemiology and Translational Research in Intensive Care, Mayo 
      Clinic, Rochester, MN; North Central Texas Medical Foundation, Wichita Falls 
      Family Practice Residency Program, Wichita Falls, TX.
FAU - Thongprayoon, Charat
AU  - Thongprayoon C
AD  - Multidisciplinary Epidemiology and Translational Research in Intensive Care, Mayo 
      Clinic, Rochester, MN; Department of Anesthesiology, Mayo Clinic, Rochester, MN. 
      Electronic address: thongprayoon.charat@mayo.edu.
FAU - Schenck, Louis A
AU  - Schenck LA
AD  - Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN.
FAU - Malinchoc, Michael
AU  - Malinchoc M
AD  - Multidisciplinary Epidemiology and Translational Research in Intensive Care, Mayo 
      Clinic, Rochester, MN; Division of Biomedical Statistics and Informatics, Mayo 
      Clinic, Rochester, MN.
FAU - Konvalinova, Andrea
AU  - Konvalinova A
AD  - Multidisciplinary Epidemiology and Translational Research in Intensive Care, Mayo 
      Clinic, Rochester, MN.
FAU - Keegan, Mark T
AU  - Keegan MT
AD  - Multidisciplinary Epidemiology and Translational Research in Intensive Care, Mayo 
      Clinic, Rochester, MN; Department of Anesthesiology, Mayo Clinic, Rochester, MN.
FAU - Gajic, Ognjen
AU  - Gajic O
AD  - Multidisciplinary Epidemiology and Translational Research in Intensive Care, Mayo 
      Clinic, Rochester, MN; Division of Pulmonary and Critical Care Medicine, Mayo 
      Clinic, Rochester, MN.
FAU - Pickering, Brian W
AU  - Pickering BW
AD  - Multidisciplinary Epidemiology and Translational Research in Intensive Care, Mayo 
      Clinic, Rochester, MN; Department of Anesthesiology, Mayo Clinic, Rochester, MN.
LA  - eng
PT  - Journal Article
DEP - 20150128
PL  - England
TA  - Mayo Clin Proc
JT  - Mayo Clinic proceedings
JID - 0405543
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - *Hospital Mortality
MH  - Humans
MH  - Intensive Care Units
MH  - Length of Stay/*statistics & numerical data
MH  - Male
MH  - Medical Errors/*statistics & numerical data
MH  - Middle Aged
MH  - Respiratory Distress Syndrome/*mortality
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Survival Analysis
EDAT- 2015/02/02 06:00
MHDA- 2015/04/29 06:00
CRDT- 2015/02/02 06:00
PHST- 2014/06/13 00:00 [received]
PHST- 2014/11/18 00:00 [revised]
PHST- 2014/12/11 00:00 [accepted]
PHST- 2015/02/02 06:00 [entrez]
PHST- 2015/02/02 06:00 [pubmed]
PHST- 2015/04/29 06:00 [medline]
AID - S0025-6196(14)01138-0 [pii]
AID - 10.1016/j.mayocp.2014.12.015 [doi]
PST - ppublish
SO  - Mayo Clin Proc. 2015 Mar;90(3):321-8. doi: 10.1016/j.mayocp.2014.12.015. Epub 
      2015 Jan 28.