PMID- 25638565
OWN - NLM
STAT- MEDLINE
DCOM- 20160328
LR  - 20200319
IS  - 1573-6830 (Electronic)
IS  - 0272-4340 (Print)
IS  - 0272-4340 (Linking)
VI  - 35
IP  - 5
DP  - 2015 Jul
TI  - Wharton's Jelly Transplantation Improves Neurologic Function in a Rat Model of 
      Traumatic Brain Injury.
PG  - 641-9
LID - 10.1007/s10571-015-0159-9 [doi]
AB  - Traumatic brain injury (TBI), which can lead to disability, dysfunction, and even 
      death, is a prominent health problem worldwide. Effective therapy for this 
      serious and debilitating condition is needed. Human umbilical cord matrix, known 
      as Wharton's jelly (WJ), provides a natural, interface scaffold that is enriched 
      in mesenchymal stem cells. In this study, we tested the efficacy of WJ tissue 
      transplantation in a weight-drop model of TBI in rats. WJ tissue was cultured and 
      transplanted into the injury site 24 h after TBI. The modified neurologic 
      severity score, body weight, brain edema, and lesion volume were evaluated at 
      various time points after TBI. Cognitive behavior was assessed by the novel 
      object recognition test and the Morris water maze test. Expression of 
      brain-derived neurotrophic factor (BDNF) in the perilesional brain area was 
      measured at day 14 after TBI. We found that WJ tissue transplantation lessened 
      TBI-induced brain edema (day 3), reduced lesion volume (day 28), improved 
      neurologic function (days 21-28), and promoted memory and cognitive recovery. 
      Additionally, expression of BDNF mRNA and protein was higher in WJ tissue-treated 
      rats than in sham-operated or vehicle-treated rats. These data suggest that WJ 
      tissue transplantation can reduce TBI-induced brain injury and may have 
      therapeutic potential for the treatment of TBI.
FAU - Cheng, Tian
AU  - Cheng T
AD  - The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, 
      People's Republic of China.
FAU - Yang, Bo
AU  - Yang B
FAU - Li, Dongpeng
AU  - Li D
FAU - Ma, Shanshan
AU  - Ma S
FAU - Tian, Yi
AU  - Tian Y
FAU - Qu, Ruina
AU  - Qu R
FAU - Zhang, Wenjin
AU  - Zhang W
FAU - Zhang, Yanting
AU  - Zhang Y
FAU - Hu, Kai
AU  - Hu K
FAU - Guan, Fangxia
AU  - Guan F
FAU - Wang, Jian
AU  - Wang J
LA  - eng
GR  - K01AG031926/AG/NIA NIH HHS/United States
GR  - R01AT007317/AT/NCCIH NIH HHS/United States
GR  - R01NS078026/NS/NINDS NIH HHS/United States
GR  - R01 AT007317/AT/NCCIH NIH HHS/United States
GR  - R01 NS078026/NS/NINDS NIH HHS/United States
GR  - K01 AG031926/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150201
PL  - United States
TA  - Cell Mol Neurobiol
JT  - Cellular and molecular neurobiology
JID - 8200709
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (MAP2 protein, rat)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Brain Edema/pathology/physiopathology/therapy
MH  - Brain Injuries/pathology/*physiopathology/*therapy
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Cognition
MH  - Disease Models, Animal
MH  - Gene Expression Regulation
MH  - Male
MH  - Microtubule-Associated Proteins/metabolism
MH  - Neurons/metabolism
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats, Sprague-Dawley
MH  - Recovery of Function
MH  - Wharton Jelly/*transplantation
PMC - PMC4481175
MID - NIHMS660392
EDAT- 2015/02/02 06:00
MHDA- 2016/03/29 06:00
PMCR- 2016/07/01
CRDT- 2015/02/02 06:00
PHST- 2014/10/06 00:00 [received]
PHST- 2015/01/22 00:00 [accepted]
PHST- 2015/02/02 06:00 [entrez]
PHST- 2015/02/02 06:00 [pubmed]
PHST- 2016/03/29 06:00 [medline]
PHST- 2016/07/01 00:00 [pmc-release]
AID - 10.1007/s10571-015-0159-9 [doi]
PST - ppublish
SO  - Cell Mol Neurobiol. 2015 Jul;35(5):641-9. doi: 10.1007/s10571-015-0159-9. Epub 
      2015 Feb 1.