PMID- 25639306
OWN - NLM
STAT- MEDLINE
DCOM- 20150608
LR  - 20161125
IS  - 1881-7831 (Print)
IS  - 1881-7831 (Linking)
VI  - 8
IP  - 6
DP  - 2014 Dec
TI  - Development of mucoadhesive buccal films from rice for pharmaceutical delivery 
      systems.
PG  - 262-7
LID - 10.5582/ddt.2014.01041 [doi]
AB  - The aim of this work was to investigate the suitable rice varieties for 
      developing pharmaceutical buccal films. Two rice varieties with extreme 
      difference in amylose content were used. Rice powders were chemically modified to 
      yield the carboxymethyl rice prior to film preparation. Scanning electron 
      microscope (SEM) and X-ray diffractometer (XRD) were used to investigate the 
      solid structure of rice powders. The results indicated that amylose content in 
      the rice grains played the effects on the morphology and crystalline structure of 
      the modified rice powders as well as the film properties. The modified rice 
      powders of low amylose content showed halo pattern XRD whereas some crystalline 
      peaks could be observed from the high amylose content modified rice powders. 
      Adding of glycerin caused the films better properties of more transparency and 
      getting rid of air bubbles. High amylose rice films showed more transparency and 
      higher mucoadhesive property and was considered to be suitable for incorporating 
      the drug. Adding of surfactant caused the increase in tensile strength and 
      decrease in elongation of the rice films. The most suitable surfactant for 
      diclofenac buccal rice film is Tween 20. This study demonstrates that rice grains 
      are the promising natural source for pharmaceutical film forming agent. Suitable 
      pharmaceutical buccal films could be developed from the rice with high amylose 
      content.
FAU - Okonogi, Siriporn
AU  - Okonogi S
AD  - Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai 
      University.
FAU - Khongkhunthian, Sakornrat
AU  - Khongkhunthian S
FAU - Jaturasitha, Sanchai
AU  - Jaturasitha S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Drug Discov Ther
JT  - Drug discoveries & therapeutics
JID - 101493809
RN  - 0 (Tissue Adhesives)
RN  - 9005-82-7 (Amylose)
SB  - IM
MH  - Adhesiveness
MH  - Amylose/chemistry
MH  - *Drug Delivery Systems
MH  - Mechanical Phenomena
MH  - *Mouth Mucosa
MH  - Oryza/*chemistry
MH  - Tensile Strength
MH  - Tissue Adhesives/*chemistry
MH  - X-Ray Diffraction
EDAT- 2015/02/03 06:00
MHDA- 2015/06/09 06:00
CRDT- 2015/02/03 06:00
PHST- 2015/02/03 06:00 [entrez]
PHST- 2015/02/03 06:00 [pubmed]
PHST- 2015/06/09 06:00 [medline]
AID - 10.5582/ddt.2014.01041 [doi]
PST - ppublish
SO  - Drug Discov Ther. 2014 Dec;8(6):262-7. doi: 10.5582/ddt.2014.01041.