PMID- 25639689 OWN - NLM STAT- MEDLINE DCOM- 20160107 LR - 20150413 IS - 1532-8414 (Electronic) IS - 1071-9164 (Linking) VI - 21 IP - 4 DP - 2015 Apr TI - Serum brain-derived neurotropic factor level predicts adverse clinical outcomes in patients with heart failure. PG - 300-6 LID - S1071-9164(15)00023-8 [pii] LID - 10.1016/j.cardfail.2015.01.003 [doi] AB - BACKGROUND: Brain-derived neurotropic factor (BDNF) is involved in cardiovascular diseases as well as skeletal muscle energy metabolism and depression. We investigated whether serum BDNF level was associated with prognosis in patients with heart failure (HF). METHODS AND RESULTS: We measured the serum BDNF level in 58 patients with HF (59.2 +/- 13.7 years old, New York Heart Association functional class I-III) at baseline, and adverse events, including all cardiac deaths and HF rehospitalizations, were recorded during the median follow-up of 20.3 months. In a univariate analysis, serum BDNF levels were significantly associated with peak oxygen capacity (beta = 0.547; P = .003), anaerobic threshold (beta = 0.929; P = .004), and log minute ventilation/carbon dioxide production slope (beta = -10.15; P = .005), but not Patient Health Questionnaire scores (beta = -0.099; P = .586). A multivariate analysis demonstrated that serum BDNF level was an independent prognostic factor of adverse events (hazard ratio 0.41, 95% confidence interval 0.20-0.84; P = .003). The receiver operating characteristic curve demonstrated that low levels of BDNF (<17.4 ng/mL) were associated with higher rates of adverse events compared with high levels of BDNF (>/=17.4 ng/mL; log rank test: P < .001). CONCLUSIONS: Decreased serum BDNF levels were significantly associated with adverse outcomes in HF patients, suggesting that these levels can be a useful prognostic biomarker. CI - Copyright (c) 2015 Elsevier Inc. All rights reserved. FAU - Fukushima, Arata AU - Fukushima A AD - Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan. FAU - Kinugawa, Shintaro AU - Kinugawa S AD - Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan. Electronic address: tuckahoe@med.hokudai.ac.jp. FAU - Homma, Tsuneaki AU - Homma T AD - Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan. FAU - Masaki, Yoshihiro AU - Masaki Y AD - Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan. FAU - Furihata, Takaaki AU - Furihata T AD - Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan. FAU - Yokota, Takashi AU - Yokota T AD - Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan. FAU - Matsushima, Shouji AU - Matsushima S AD - Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan. FAU - Takada, Shingo AU - Takada S AD - Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan. FAU - Kadoguchi, Tomoyasu AU - Kadoguchi T AD - Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan. FAU - Oba, Koji AU - Oba K AD - Translational Research and Clinical Trial Center, Hokkaido University Hospital, Sapporo, Japan. FAU - Okita, Koichi AU - Okita K AD - Graduate School of Program in Lifelong Learning Studies, Hokusho University, Ebetsu, Japan. FAU - Tsutsui, Hiroyuki AU - Tsutsui H AD - Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan. LA - eng PT - Journal Article DEP - 20150130 PL - United States TA - J Card Fail JT - Journal of cardiac failure JID - 9442138 RN - 0 (Biomarkers) RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Adult MH - Aged MH - Biomarkers/blood MH - Brain-Derived Neurotrophic Factor/*blood MH - Exercise Test MH - Female MH - Heart Failure/*blood/mortality/physiopathology MH - Humans MH - Japan/epidemiology MH - Male MH - Middle Aged MH - *Oxygen Consumption MH - Prognosis MH - ROC Curve MH - Retrospective Studies MH - Survival Rate/trends MH - Young Adult OTO - NOTNLM OT - Heart failure OT - brain-derived neurotrophic factor OT - exercise capacity OT - prognosis EDAT- 2015/02/03 06:00 MHDA- 2016/01/08 06:00 CRDT- 2015/02/03 06:00 PHST- 2014/05/30 00:00 [received] PHST- 2014/12/01 00:00 [revised] PHST- 2015/01/23 00:00 [accepted] PHST- 2015/02/03 06:00 [entrez] PHST- 2015/02/03 06:00 [pubmed] PHST- 2016/01/08 06:00 [medline] AID - S1071-9164(15)00023-8 [pii] AID - 10.1016/j.cardfail.2015.01.003 [doi] PST - ppublish SO - J Card Fail. 2015 Apr;21(4):300-6. doi: 10.1016/j.cardfail.2015.01.003. Epub 2015 Jan 30.