PMID- 25639690
OWN - NLM
STAT- MEDLINE
DCOM- 20160212
LR  - 20181222
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 21
IP  - 5
DP  - 2015 May
TI  - Effect of intravenous immunoglobulin for fulminant myocarditis on in-hospital 
      mortality: propensity score analyses.
PG  - 391-397
LID - S1071-9164(15)00024-X [pii]
LID - 10.1016/j.cardfail.2015.01.004 [doi]
AB  - BACKGROUND: Fulminant myocarditis (FM) is a rare but life-threatening disease. 
      Intravenous immunoglobulin (IVIG) is not recommended for acute or chronic 
      myocarditis in Western nations owing to the lack of rigorous evidence, but it is 
      widely used in other countries, including Japan. This nationwide retrospective 
      cohort study focused on evaluating the effect of IVIG in FM patients. METHODS AND 
      RESULTS: Using the Diagnosis Procedure Combination database in Japan, we 
      identified 603 FM patients aged >/=16 years who received mechanical circulatory 
      support within 7 days after admission. We performed propensity score analyses to 
      compare the in-hospital mortality and total costs between IVIG users (n = 220; 
      36.5%) and nonusers (n = 383; 63.5%). Among propensity score-matched patients 
      (164 pairs), there was no significant difference in in-hospital mortality between 
      IVIG users and nonusers (36.6% vs 37.2%; P = .909). A multivariable logistic 
      regression analysis showed no significant association between IVIG use and 
      in-hospital mortality (adjusted odds ratio 0.91; 95% confidence interval 0.52 to 
      1.58; P = .733). The median total costs were significantly higher for IVIG users 
      than for nonusers (US $44,226 vs $33,280; P < .001). CONCLUSION: IVIG for FM was 
      not significantly associated with a decrease in in-hospital mortality.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Isogai, Toshiaki
AU  - Isogai T
AD  - Department of Clinical Epidemiology and Health Economics, School of Public 
      Health, The University of Tokyo, Tokyo, Japan; Department of Cardiology, Tokyo 
      Metropolitan Tama Medical Center, Tokyo, Japan. Electronic address: 
      toisogai-circ@umin.ac.jp.
FAU - Yasunaga, Hideo
AU  - Yasunaga H
AD  - Department of Clinical Epidemiology and Health Economics, School of Public 
      Health, The University of Tokyo, Tokyo, Japan.
FAU - Matsui, Hiroki
AU  - Matsui H
AD  - Department of Clinical Epidemiology and Health Economics, School of Public 
      Health, The University of Tokyo, Tokyo, Japan.
FAU - Tanaka, Hiroyuki
AU  - Tanaka H
AD  - Department of Cardiology, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan.
FAU - Horiguchi, Hiromasa
AU  - Horiguchi H
AD  - Department of Clinical Data Management and Research, Clinical Research Center, 
      National Hospital Organization Headquarters, Tokyo, Japan.
FAU - Fushimi, Kiyohide
AU  - Fushimi K
AD  - Department of Health Policy and Informatics, Graduate School of Medicine, Tokyo 
      Medical and Dental University, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150130
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Immunologic Factors)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Databases, Factual/trends
MH  - Female
MH  - Hospital Mortality/*trends
MH  - Humans
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Immunologic Factors/*therapeutic use
MH  - Japan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Myocarditis/*drug therapy/epidemiology/*mortality
MH  - Propensity Score
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Fulminant myocarditis
OT  - immunoglobulin
OT  - mortality
OT  - propensity score analysis
EDAT- 2015/02/03 06:00
MHDA- 2016/02/13 06:00
CRDT- 2015/02/03 06:00
PHST- 2014/07/26 00:00 [received]
PHST- 2014/12/31 00:00 [revised]
PHST- 2015/01/23 00:00 [accepted]
PHST- 2015/02/03 06:00 [entrez]
PHST- 2015/02/03 06:00 [pubmed]
PHST- 2016/02/13 06:00 [medline]
AID - S1071-9164(15)00024-X [pii]
AID - 10.1016/j.cardfail.2015.01.004 [doi]
PST - ppublish
SO  - J Card Fail. 2015 May;21(5):391-397. doi: 10.1016/j.cardfail.2015.01.004. Epub 
      2015 Jan 30.