PMID- 25639755
OWN - NLM
STAT- MEDLINE
DCOM- 20151120
LR  - 20171116
IS  - 1744-313X (Electronic)
IS  - 1744-3121 (Linking)
VI  - 42
IP  - 2
DP  - 2015 Apr
TI  - Monocyte chemoattractant protein-1 gene polymorphism and its serum level have an 
      impact on anthropometric and biochemical risk factors of metabolic syndrome in 
      Indian population.
PG  - 78-86
LID - 10.1111/iji.12174 [doi]
AB  - Monocyte chemoattractant protein-1 (MCP-1), encoded by gene CCL-2 (Chemokine C-C 
      motif 2), is the ligand of chemokine receptor CCR-2. Concurrent clinical 
      alteration in several metabolic aspects, including central obesity, dysglycemia, 
      dyslipidemia and hypertension, is clinically characterized as metabolic syndrome 
      (MetS). Role of MCP-1 in each of these aspects has been established in vitro and 
      in animal studies as well. We here report genetic association of -2518 A>G MCP-1 
      (rs 1024611) gene polymorphism and level of MCP-1 with MetS in North Indian 
      subjects. We analysed (n=386, controls and n=384, MetS subjects) for MCP-1 gene 
      polymorphism using PCR-RFLP, its serum level using ELISA, anthropometric (body 
      mass index, waist and hip circumferences, waist-hip ratio and blood pressure) and 
      biochemical (serum lipids, plasma glucose and insulin levels) variables in a 
      genetic association study. The body mass index, waist circumference, hip 
      circumference, waist-hip ratio, blood pressure, serum lipids, insulin and fasting 
      plasma glucose level were significantly high in MetS subjects. Regression 
      analysis showed significant correlation of body mass index, waist and hip 
      circumference, systolic/diastolic blood pressure, fasting glucose, total 
      cholesterol, high-density lipoprotein, low-density lipoprotein fasting insulin 
      and HOMA-IR with MetS. MCP-1 allele and genotype were significantly associated 
      with MetS. Serum MCP-1 level was high in overall cases. In conclusions, the MCP-1 
      2518A>G (rs 1024611) polymorphism has significant impact on risk of MetS, and 
      MCP-1 level correlates with anthropometric and biochemical risk factors of MetS.
CI  - (c) 2015 John Wiley & Sons Ltd.
FAU - Madeshiya, A K
AU  - Madeshiya AK
AD  - Department of Physiology, King George's Medical University, Lucknow, India.
FAU - Singh, S
AU  - Singh S
FAU - Dwivedi, S
AU  - Dwivedi S
FAU - Saini, K S
AU  - Saini KS
FAU - Singh, R
AU  - Singh R
FAU - Tiwari, S
AU  - Tiwari S
FAU - Konwar, R
AU  - Konwar R
FAU - Ghatak, A
AU  - Ghatak A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150130
PL  - England
TA  - Int J Immunogenet
JT  - International journal of immunogenetics
JID - 101232337
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - *Body Weights and Measures
MH  - Case-Control Studies
MH  - Chemokine CCL2/*blood/*genetics
MH  - Female
MH  - *Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - India
MH  - Male
MH  - Metabolic Syndrome/*blood/*genetics
MH  - Middle Aged
MH  - Odds Ratio
MH  - Risk Factors
EDAT- 2015/02/03 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/02/03 06:00
PHST- 2014/07/03 00:00 [received]
PHST- 2014/09/22 00:00 [revised]
PHST- 2014/12/14 00:00 [accepted]
PHST- 2015/02/03 06:00 [entrez]
PHST- 2015/02/03 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.1111/iji.12174 [doi]
PST - ppublish
SO  - Int J Immunogenet. 2015 Apr;42(2):78-86. doi: 10.1111/iji.12174. Epub 2015 Jan 
      30.