PMID- 25640280
OWN - NLM
STAT- MEDLINE
DCOM- 20151120
LR  - 20221207
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 5
DP  - 2015 Feb 2
TI  - The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor 
      levels in Han Chinese heroin-dependent patients.
PG  - 8148
LID - 10.1038/srep08148 [doi]
LID - 8148
AB  - BDNF and its gene polymorphism may be important in synaptic plasticity and neuron 
      survival, and may become a key target in the physiopathology of long-term heroin 
      use. Thus, we investigated the relationships between brain-derived neurotrophic 
      factor (BDNF) plasma concentrations and the BDNF Val66Met nucleotide polymorphism 
      (SNP) in heroin-dependent patients. The pretreatment expression levels of plasma 
      BDNF and the BDNF Val66Met SNP in 172 heroin-dependent patients and 102 healthy 
      controls were checked. BDNF levels were significantly lower in patients (F = 
      52.28, p < 0.0001), but the distribution of the SNP was not significantly 
      different. Nor were plasma BDNF levels significantly different between Met/Met, 
      Met/Val, and Val/Val carriers in each group, which indicated that the BDNF 
      Val66Met SNP did not affect plasma BDNF levels in our participants. In 
      heroin-dependent patients, plasma BDNF levels were negatively correlated with the 
      length of heroin dependency. Long-term (>15 years) users had significantly lower 
      plasma BDNF levels than did short-term (<5 years) users. We conclude that plasma 
      BDNF concentration in habitual heroin users are not affected by BDNF Val66Met 
      gene variants, but by the length of the heroin dependency.
FAU - Chen, Shiou-Lan
AU  - Chen SL
AD  - Department of Neurology, School of Medicine, Kaohsiung Medical University, 
      Kaohsiung, Taiwan.
FAU - Lee, Sheng-Yu
AU  - Lee SY
AD  - Department of Psychiatry, Kaohsiung Veteran's General Hospital, Kaohsiung, 
      Taiwan.
FAU - Chang, Yun-Hsuan
AU  - Chang YH
AD  - 1] Department of Psychiatry, National Cheng Kung University, Taiwan, Taiwan [2] 
      Department of Psychiatry, National Cheng Kung Hospital, Taiwan, Taiwan.
FAU - Wang, Tzu-Yun
AU  - Wang TY
AD  - 1] Department of Psychiatry, National Cheng Kung University, Taiwan, Taiwan [2] 
      Department of Psychiatry, National Cheng Kung Hospital, Taiwan, Taiwan.
FAU - Chen, Shih-Heng
AU  - Chen SH
AD  - Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National 
      Institute of Environmental Health Sciences/National Institutes of Health, 
      Research Triangle Park, North Carolina, USA.
FAU - Chu, Chun-Hsien
AU  - Chu CH
AD  - Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National 
      Institute of Environmental Health Sciences/National Institutes of Health, 
      Research Triangle Park, North Carolina, USA.
FAU - Chen, Po See
AU  - Chen PS
AD  - 1] Department of Psychiatry, National Cheng Kung University, Taiwan, Taiwan [2] 
      Department of Psychiatry, National Cheng Kung Hospital, Taiwan, Taiwan.
FAU - Yang, Yen Kuang
AU  - Yang YK
AD  - 1] Department of Psychiatry, National Cheng Kung University, Taiwan, Taiwan [2] 
      Department of Psychiatry, National Cheng Kung Hospital, Taiwan, Taiwan.
FAU - Hong, Jau-Shyong
AU  - Hong JS
AD  - Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National 
      Institute of Environmental Health Sciences/National Institutes of Health, 
      Research Triangle Park, North Carolina, USA.
FAU - Lu, Ru-Band
AU  - Lu RB
AD  - 1] Institute of Behavioral Medicine, National Cheng Kung University, Taiwan, 
      Taiwan [2] Department of Psychiatry, National Cheng Kung University, Taiwan, 
      Taiwan [3] Department of Psychiatry, National Cheng Kung Hospital, Taiwan, Taiwan 
      [4] Institute of Allied Health Sciences, College of Medicine, National Cheng Kung 
      University, Taiwan, Taiwan [5] Addiction Research Center, National Cheng Kung 
      University, Taiwan, Taiwan [6] Center for Neuropsychiatric Research, National 
      Health Research Institute, Tainan, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150202
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 70D95007SX (Heroin)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Asian People/*genetics
MH  - Brain-Derived Neurotrophic Factor/blood/*genetics
MH  - China
MH  - Down-Regulation
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Heroin/administration & dosage
MH  - Humans
MH  - Male
MH  - *Polymorphism, Single Nucleotide
MH  - Substance-Related Disorders/*genetics/pathology
MH  - Time Factors
PMC - PMC4313085
EDAT- 2015/02/03 06:00
MHDA- 2015/12/15 06:00
PMCR- 2015/02/02
CRDT- 2015/02/03 06:00
PHST- 2014/08/05 00:00 [received]
PHST- 2014/12/04 00:00 [accepted]
PHST- 2015/02/03 06:00 [entrez]
PHST- 2015/02/03 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2015/02/02 00:00 [pmc-release]
AID - srep08148 [pii]
AID - 10.1038/srep08148 [doi]
PST - epublish
SO  - Sci Rep. 2015 Feb 2;5:8148. doi: 10.1038/srep08148.