PMID- 25640838
OWN - NLM
STAT- MEDLINE
DCOM- 20150506
LR  - 20220310
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 458
IP  - 1
DP  - 2015 Feb 27
TI  - Mitochondrial Ca(2)(+) uniporter is critical for store-operated Ca(2)(+) entry-dependent 
      breast cancer cell migration.
PG  - 186-93
LID - S0006-291X(15)00131-X [pii]
LID - 10.1016/j.bbrc.2015.01.092 [doi]
AB  - Metastasis of cancer cells is a complicated multistep process requiring extensive 
      and continuous cytosolic calcium modulation. Mitochondrial Ca(2+) uniporter 
      (MCU), a regulator of mitochondrial Ca(2+) uptake, has been implicated in energy 
      metabolism and various cellular signaling processes. However, whether MCU 
      contributes to cancer cell migration has not been established. Here we examined 
      the expression of MCU mRNA in the Oncomine database and found that MCU is 
      correlated to metastasis and invasive breast cancer. MCU inhibition by ruthenium 
      red (RuR) or MCU silencing by siRNA abolished serum-induced migration in 
      MDA-MB-231 breast cancer cells and reduced serum- or thapsigargin (TG)-induced 
      store-operated Ca2+ entry (SOCE). Serum-induced migrations in MDA-MB-231 cells 
      were blocked by SOCE inhibitors. Our results demonstrate that MCU plays a 
      critical role in breast cancer cell migration by regulating SOCE.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Tang, Shihao
AU  - Tang S
AD  - Department of Occupational Health and Occupational Medicine, School of Public 
      Health and Tropical Medicine, Southern Medical University, Guangzhou, Guangdong, 
      China; Guangzhou No.12 Hospital, Guangzhou, China.
FAU - Wang, Xubu
AU  - Wang X
AD  - Department of Occupational Health and Occupational Medicine, School of Public 
      Health and Tropical Medicine, Southern Medical University, Guangzhou, Guangdong, 
      China.
FAU - Shen, Qiang
AU  - Shen Q
AD  - Department of Clinical Cancer Prevention, The University of Texas MD Anderson 
      Cancer Center, Houston, TX, USA.
FAU - Yang, Xinyi
AU  - Yang X
AD  - Department of Occupational Health and Occupational Medicine, School of Public 
      Health and Tropical Medicine, Southern Medical University, Guangzhou, Guangdong, 
      China.
FAU - Yu, Changhui
AU  - Yu C
AD  - Department of Occupational Health and Occupational Medicine, School of Public 
      Health and Tropical Medicine, Southern Medical University, Guangzhou, Guangdong, 
      China.
FAU - Cai, Chunqing
AU  - Cai C
AD  - Department of Occupational Health and Occupational Medicine, School of Public 
      Health and Tropical Medicine, Southern Medical University, Guangzhou, Guangdong, 
      China.
FAU - Cai, Guoshuai
AU  - Cai G
AD  - Department of Bioinformatics and Computational Biology, The University of Texas 
      MD Anderson Cancer Center, Houston, TX, USA.
FAU - Meng, Xiaojing
AU  - Meng X
AD  - Department of Occupational Health and Occupational Medicine, School of Public 
      Health and Tropical Medicine, Southern Medical University, Guangzhou, Guangdong, 
      China. Electronic address: xiaojingmeng@smu.edu.cn.
FAU - Zou, Fei
AU  - Zou F
AD  - Department of Occupational Health and Occupational Medicine, School of Public 
      Health and Tropical Medicine, Southern Medical University, Guangzhou, Guangdong, 
      China. Electronic address: zoufei616@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150129
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Calcium Channel Blockers)
RN  - 0 (Calcium Channels)
RN  - 0 (Imidazoles)
RN  - 0 (mitochondrial calcium uniporter)
RN  - 11103-72-3 (Ruthenium Red)
RN  - 67526-95-8 (Thapsigargin)
RN  - I61V87164A (1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Breast Neoplasms/genetics/metabolism/*pathology
MH  - Calcium/*metabolism
MH  - Calcium Channel Blockers/pharmacology
MH  - Calcium Channels/*genetics/*metabolism
MH  - Cell Line, Tumor
MH  - Cell Movement/drug effects
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Imidazoles/pharmacology
MH  - Mitochondria/drug effects/metabolism
MH  - Ruthenium Red/pharmacology
MH  - Thapsigargin/pharmacology
OTO - NOTNLM
OT  - Breast tumor
OT  - MCU
OT  - Migration
OT  - SOCE
EDAT- 2015/02/03 06:00
MHDA- 2015/05/07 06:00
CRDT- 2015/02/03 06:00
PHST- 2015/01/11 00:00 [received]
PHST- 2015/01/20 00:00 [accepted]
PHST- 2015/02/03 06:00 [entrez]
PHST- 2015/02/03 06:00 [pubmed]
PHST- 2015/05/07 06:00 [medline]
AID - S0006-291X(15)00131-X [pii]
AID - 10.1016/j.bbrc.2015.01.092 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2015 Feb 27;458(1):186-93. doi: 
      10.1016/j.bbrc.2015.01.092. Epub 2015 Jan 29.