PMID- 25640857
OWN - NLM
STAT- MEDLINE
DCOM- 20151231
LR  - 20200613
IS  - 1097-0193 (Electronic)
IS  - 1065-9471 (Print)
IS  - 1065-9471 (Linking)
VI  - 36
IP  - 5
DP  - 2015 May
TI  - Disrupted resting-state functional connectivity and its changing trend in 
      migraine suffers.
PG  - 1892-907
LID - 10.1002/hbm.22744 [doi]
AB  - Chronic pain has been linked with learning and memory processes and functional 
      changes in brain plasticity in its development and maintenance via neuroimaging 
      studies. However, the principle of reorganization of the migraine brain network 
      as the brain progresses into chronic pain remain poorly understood. Here, using 
      resting-state functional magnetic resonance imaging (rs-fMRI) and graph theory 
      approaches, we aimed to investigate the dynamic dysfunctional connectivity in 108 
      patients with migraine without aura (MWoA) and 30 gender-matched healthy controls 
      (HC). All patients were divided into 40 groups using a sliding boxcar grouping of 
      subjects in disease duration order. As compared with HC, nonparametric 
      permutation tests were applied for between-group comparisons of functional 
      connectivity strength in each patient group. We focused only on the between-group 
      differences of functional connections in MWoA, and the situation how these 
      different connections were organized along with the changing trend. As the 
      disease duration increased, the presence of chronic headache altered the 
      functional connectivity from the local central nervous system (CNS) to a 
      disruption in the whole-brain networks. These dysfunctional connections 
      integrated into a connected component in relatively longer migraine duration 
      groups, suggesting an abnormal integrated network configuration with ongoing 
      central changes for long-term migraine. Within these between-group differences of 
      the connected component, there were contained a small number of brain regions 
      that had disproportionately numerous connections. Moreover, these brain regions 
      exhibited a tendency to link to each other were organized into a strongly 
      interconnected community. These interconnected brain regions were mainly located 
      in the sensory-discriminative brain areas. Our results exhibited a working model 
      of the central mechanisms of migraine where the brain functional connectivity was 
      altered from the local central nervous system to a densely interconnected center, 
      which may extend our understanding of the role of learning mechanisms which are 
      likely involved in maintenance of chronic pain.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Liu, Jixin
AU  - Liu J
AD  - School of Life Science and Technology, Xidian University, Xi'an, People's 
      Republic of China.
FAU - Zhao, Ling
AU  - Zhao L
FAU - Lei, Fangfei
AU  - Lei F
FAU - Zhang, Yi
AU  - Zhang Y
FAU - Yuan, Kai
AU  - Yuan K
FAU - Gong, Qiyong
AU  - Gong Q
FAU - Liang, Fanrong
AU  - Liang F
FAU - Tian, Jie
AU  - Tian J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150130
PL  - United States
TA  - Hum Brain Mapp
JT  - Human brain mapping
JID - 9419065
SB  - IM
MH  - Adult
MH  - Brain/*physiopathology
MH  - Brain Mapping
MH  - Chronic Disease
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Migraine without Aura/*physiopathology
MH  - Neural Pathways/physiopathology
MH  - Neuronal Plasticity
MH  - Rest
MH  - Signal Processing, Computer-Assisted
MH  - Statistics, Nonparametric
MH  - Time Factors
PMC - PMC6869678
OTO - NOTNLM
OT  - brain network development
OT  - functional magnetic resonance imaging
OT  - migraine
OT  - the sensory-discriminative brain regions
EDAT- 2015/02/03 06:00
MHDA- 2016/01/01 06:00
PMCR- 2015/01/30
CRDT- 2015/02/03 06:00
PHST- 2014/07/16 00:00 [received]
PHST- 2014/12/22 00:00 [revised]
PHST- 2015/01/12 00:00 [accepted]
PHST- 2015/02/03 06:00 [entrez]
PHST- 2015/02/03 06:00 [pubmed]
PHST- 2016/01/01 06:00 [medline]
PHST- 2015/01/30 00:00 [pmc-release]
AID - HBM22744 [pii]
AID - 10.1002/hbm.22744 [doi]
PST - ppublish
SO  - Hum Brain Mapp. 2015 May;36(5):1892-907. doi: 10.1002/hbm.22744. Epub 2015 Jan 
      30.