PMID- 25641742
OWN - NLM
STAT- MEDLINE
DCOM- 20151125
LR  - 20191008
IS  - 1097-4547 (Electronic)
IS  - 0360-4012 (Print)
IS  - 0360-4012 (Linking)
VI  - 93
IP  - 5
DP  - 2015 May
TI  - Tumor necrosis factor-alpha potentiates long-term potentiation in the rat dentate 
      gyrus after acute hypoxia.
PG  - 815-29
LID - 10.1002/jnr.23540 [doi]
AB  - An inadequate supply of oxygen in the brain may lead to an inflammatory response 
      through neuronal and glial cells that can result in neuronal damage. Tumor 
      necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine that is released during 
      acute hypoxia and can have neurotoxic or neuroprotective effects in the brain. 
      Both TNF-alpha and interleukin-1beta (IL-1beta) have been shown by a number of research 
      groups to alter synaptic scaling and also to inhibit long-term potentiation (LTP) 
      in the hippocampus when induced by specific high-frequency stimulation (HFS) 
      protocols. This study examines the effects of TNF-alpha on synaptic transmission and 
      plasticity in hippocampal slices after acute hypoxia using two HFS protocols. 
      Field excitatory postsynaptic potentials were elicited in the medial perforant 
      pathway of the dentate gyrus. Exogenous TNF-alpha (5 ng/ml) attenuated LTP induced by 
      theta burst stimulation but had no effect on LTP induced by a more prolonged HFS. 
      Pretreatment with lipopolysaccharide (100 ng/ml) or TNF-alpha but not IL-1beta (4 ng/ml) 
      prior to a 30-min hypoxic insult resulted in a significant enhancement of LTP 
      post hypoxia when induced by the HFS. Anti-TNF, 3,6'-dithiothalidomide (a TNF-alpha 
      synthesis inhibitor), and SB203580 (a p38 MAPK inhibitor) significantly reduced 
      this effect. These results indicate an important modulatory role for elevated 
      TNF-alpha levels on LTP in the hippocampus after an acute hypoxic event.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Wall, Audrey M
AU  - Wall AM
AD  - UCD School of Biomolecular and Biomedical Sciences, UCD Conway Institute of 
      Biomolecular and Biomedical Research, University College Dublin, Belfield, 
      Dublin, Ireland.
FAU - Mukandala, Gatambwa
AU  - Mukandala G
FAU - Greig, Nigel H
AU  - Greig NH
FAU - O'Connor, John J
AU  - O'Connor JJ
LA  - eng
GR  - ZIA AG000311-15/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150112
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Imidazoles)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Pyridines)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 76326-31-3 (2-amino-5-phosphopentanoic acid)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - HG18B9YRS7 (Valine)
RN  - OU13V1EYWQ (SB 203580)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Anti-Inflammatory Agents, Non-Steroidal/pharmacology
MH  - Cells, Cultured
MH  - Dentate Gyrus/*pathology
MH  - Electric Stimulation
MH  - Excitatory Postsynaptic Potentials/drug effects
MH  - Hypoxia/*pathology
MH  - Imidazoles/pharmacology
MH  - In Vitro Techniques
MH  - Interleukin-1beta/pharmacology
MH  - L-Lactate Dehydrogenase/metabolism
MH  - Lipopolysaccharides/pharmacology
MH  - Long-Term Potentiation/*drug effects
MH  - Male
MH  - Patch-Clamp Techniques
MH  - Pyridines/pharmacology
MH  - Rats
MH  - Tumor Necrosis Factor-alpha/*pharmacology
MH  - Valine/analogs & derivatives/pharmacology
PMC - PMC5187981
MID - NIHMS837279
OTO - NOTNLM
OT  - 1,6'-dithiorevlimid
OT  - 3,6'-dithiothalidomide
OT  - CNTO1081
OT  - dentate gyrus
OT  - high-frequency stimulation
OT  - hypoxia
OT  - interleukin-1beta
OT  - long-term potentiation
OT  - prolyl hydroxylase inhibition
OT  - theta burst stimulation
OT  - tumor necrosis factor-alpha
COIS- The authors state that they have no conflict of interest in the publication of 
      this manuscript.
EDAT- 2015/02/03 06:00
MHDA- 2015/12/15 06:00
PMCR- 2016/12/27
CRDT- 2015/02/03 06:00
PHST- 2014/07/29 00:00 [received]
PHST- 2014/11/12 00:00 [revised]
PHST- 2014/11/20 00:00 [accepted]
PHST- 2015/02/03 06:00 [entrez]
PHST- 2015/02/03 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2016/12/27 00:00 [pmc-release]
AID - 10.1002/jnr.23540 [doi]
PST - ppublish
SO  - J Neurosci Res. 2015 May;93(5):815-29. doi: 10.1002/jnr.23540. Epub 2015 Jan 12.