PMID- 25642416
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150202
LR  - 20200930
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 4
DP  - 2014
TI  - Safety and Tolerability of SBRT after High-Dose External Beam Radiation to the 
      Lung.
PG  - 376
LID - 10.3389/fonc.2014.00376 [doi]
LID - 376
AB  - PURPOSE: Stereotactic body radiotherapy (SBRT) is commonly used to treat 
      unresectable lung nodules. Given its relative safety and effective local control, 
      SBRT has also been used to treat recurrent lung nodules after high-dose external 
      beam radiation (EBRT) to the lung. The toxicity of such treatment is unknown. 
      METHODS AND MATERIALS: Between 2006 and 2012, 18 subjects at the Mayo Clinic with 
      27 recurrent lung nodules were treated with SBRT after receiving EBRT to the 
      lung. Median local control, overall survival, and progression-free survival (PFS) 
      were described. Acute toxicity and late toxicity (defined as toxicity >/= and 
      >90 days, respectively) were reported and graded as per standardized CTCAE 4.0 
      criteria. RESULTS: The median age of patients treated was 68 years. Fifteen 
      patients had recurrent lung cancer as their primary histology. Twelve patients 
      received >/=60 Gy of conventional EBRT prior to SBRT. SBRT dose and fractionation 
      varied; the most common prescriptions were 48 Gy/4, 54 Gy/3, and 50 Gy/5 
      fractions. Only four patients had SBRT planning target volumes (PTVs) that 
      overlapped more than 50% of their prior EBRT PTV. Two patients developed local 
      recurrence following SBRT. With a median follow up of 21.2 months, median 
      SBRT-specific overall survival and PFS were 21.7 and 12.3 months, respectively. 
      No grade >/=3 acute or late toxicities were noted. CONCLUSION: Stereotactic body 
      radiotherapy may be a good salvage option for select patients with recurrent lung 
      nodules following definitive EBRT to the chest. Toxicity is minimal and local 
      control is excellent.
FAU - Owen, Dawn
AU  - Owen D
AD  - Department of Radiation Oncology, Mayo Clinic Rochester , Rochester, MN , USA ; 
      Department of Radiation Oncology, University of Michigan , Ann Arbor, MI , USA.
FAU - Olivier, Kenneth R
AU  - Olivier KR
AD  - Department of Radiation Oncology, Mayo Clinic Rochester , Rochester, MN , USA.
FAU - Song, Limin
AU  - Song L
AD  - Department of Radiation Oncology, Mayo Clinic Rochester , Rochester, MN , USA.
FAU - Mayo, Charles S
AU  - Mayo CS
AD  - Department of Radiation Oncology, Mayo Clinic Rochester , Rochester, MN , USA.
FAU - Miller, Robert C
AU  - Miller RC
AD  - Department of Radiation Oncology, Mayo Clinic Rochester , Rochester, MN , USA.
FAU - Nelson, Kathryn
AU  - Nelson K
AD  - Department of Radiation Oncology, Mayo Clinic Rochester , Rochester, MN , USA.
FAU - Bauer, Heather
AU  - Bauer H
AD  - Department of Radiation Oncology, Mayo Clinic Rochester , Rochester, MN , USA.
FAU - Brown, Paul D
AU  - Brown PD
AD  - MD Anderson Cancer Center , Houston, TX , USA.
FAU - Park, Sean S
AU  - Park SS
AD  - Department of Radiation Oncology, Mayo Clinic Rochester , Rochester, MN , USA.
FAU - Ma, Daniel J
AU  - Ma DJ
AD  - Department of Radiation Oncology, Mayo Clinic Rochester , Rochester, MN , USA.
FAU - Garces, Yolanda I
AU  - Garces YI
AD  - Department of Radiation Oncology, Mayo Clinic Rochester , Rochester, MN , USA.
LA  - eng
PT  - Journal Article
DEP - 20150114
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC4294121
OTO - NOTNLM
OT  - acute
OT  - external beam radiotherapy
OT  - late toxicity
OT  - lung cancer
OT  - reirradiation
OT  - stereotactic body radiotherapy
OT  - toxicity tests
EDAT- 2015/02/03 06:00
MHDA- 2015/02/03 06:01
PMCR- 2014/01/01
CRDT- 2015/02/03 06:00
PHST- 2014/09/12 00:00 [received]
PHST- 2014/12/16 00:00 [accepted]
PHST- 2015/02/03 06:00 [entrez]
PHST- 2015/02/03 06:00 [pubmed]
PHST- 2015/02/03 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2014.00376 [doi]
PST - epublish
SO  - Front Oncol. 2015 Jan 14;4:376. doi: 10.3389/fonc.2014.00376. eCollection 2014.