PMID- 25643710
OWN - NLM
STAT- MEDLINE
DCOM- 20151002
LR  - 20150203
IS  - 2052-5206 (Electronic)
IS  - 2052-5192 (Linking)
VI  - 71
IP  - Pt 1
DP  - 2015 Feb
TI  - The ecstasy and the agony; compression studies of 
      3,4-methylenedioxymethamphetamine (MDMA).
PG  - 3-9
LID - 10.1107/S2052520614026389 [doi]
AB  - MDMA (3,4-methylenedioxymethamphetamine) is a Class A substance that is usually 
      found in a tableted form. It is only observed in one orthorhombic polymorph under 
      ambient conditions. It shows slight positional disorder around the methlyenedioxy 
      ring which persists during compression up to 6.66 GPa. The crystal quality 
      deteriorates above 6.66 GPa where the hydrostatic limit of the 
      pressure-transmitting medium is exceeded. The structure undergoes anisotropic 
      compression with the a-axis compressing the greatest (12% cf. 4 and 10% for the 
      b- and c-axes, respectively). This is due to the pattern of the hydrogen bonding 
      which acts like a spring and allows the compression along this direction.
FAU - Connor, Lauren E
AU  - Connor LE
AD  - Strathclyde Institute of Pharmacy and Biomedical Sciences, University of 
      Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, Scotland.
FAU - Delori, Amit
AU  - Delori A
AD  - Strathclyde Institute of Pharmacy and Biomedical Sciences, University of 
      Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, Scotland.
FAU - Hutchison, Ian B
AU  - Hutchison IB
AD  - Strathclyde Institute of Pharmacy and Biomedical Sciences, University of 
      Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, Scotland.
FAU - Nic Daeid, Niamh
AU  - Nic Daeid N
AD  - Centre for Anatomy and Human Identification, University of Dundee, College of 
      Life Sciences, Dow Street, Dundee DD1 5EH, Scotland.
FAU - Sutcliffe, Oliver B
AU  - Sutcliffe OB
AD  - School of Science and the Environment, Manchester Metropolitan University, 
      Chester Street, Manchester M1 5GD, England.
FAU - Oswald, Iain D H
AU  - Oswald ID
AD  - Strathclyde Institute of Pharmacy and Biomedical Sciences, University of 
      Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, Scotland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150120
PL  - England
TA  - Acta Crystallogr B Struct Sci Cryst Eng Mater
JT  - Acta crystallographica Section B, Structural science, crystal engineering and 
      materials
JID - 101609037
RN  - 0 (Powders)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Crystallography, X-Ray
MH  - Hydrogen Bonding
MH  - Models, Molecular
MH  - Molecular Conformation
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*chemistry
MH  - Powders
MH  - Pressure
OTO - NOTNLM
OT  - MDMA
OT  - compression
OT  - ecstasy
OT  - entactogen
EDAT- 2015/02/04 06:00
MHDA- 2015/10/03 06:00
CRDT- 2015/02/04 06:00
PHST- 2014/10/27 00:00 [received]
PHST- 2014/12/01 00:00 [accepted]
PHST- 2015/02/04 06:00 [entrez]
PHST- 2015/02/04 06:00 [pubmed]
PHST- 2015/10/03 06:00 [medline]
AID - S2052520614026389 [pii]
AID - 10.1107/S2052520614026389 [doi]
PST - ppublish
SO  - Acta Crystallogr B Struct Sci Cryst Eng Mater. 2015 Feb;71(Pt 1):3-9. doi: 
      10.1107/S2052520614026389. Epub 2015 Jan 20.