PMID- 25644420
OWN - NLM
STAT- MEDLINE
DCOM- 20151215
LR  - 20220310
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 290
DP  - 2015 Apr 2
TI  - Aging and large-scale functional networks: white matter integrity, gray matter 
      volume, and functional connectivity in the resting state.
PG  - 369-78
LID - S0306-4522(15)00105-0 [pii]
LID - 10.1016/j.neuroscience.2015.01.049 [doi]
AB  - Healthy aging is accompanied by neurobiological changes that affect the brain's 
      functional organization and the individual's cognitive abilities. The aim of this 
      study was to investigate the effect of global age-related differences in the 
      cortical white and gray matter on neural activity in three key large-scale 
      networks. We used functional-structural covariance network analysis to assess 
      resting state activity in the default mode network (DMN), the fronto-parietal 
      network (FPN), and the salience network (SN) of young and older adults. We 
      further related this functional activity to measures of cortical thickness and 
      volume derived from structural MRI, as well as to measures of white matter 
      integrity (fractional anisotropy [FA], mean diffusivity [MD], and radial 
      diffusivity [RD]) derived from diffusion-weighted imaging. First, our results 
      show that, in the direct comparison of resting state activity, young but not 
      older adults reliably engage the SN and FPN in addition to the DMN, suggesting 
      that older adults recruit these networks less consistently. Second, our results 
      demonstrate that age-related decline in white matter integrity and gray matter 
      volume is associated with activity in prefrontal nodes of the SN and FPN, 
      possibly reflecting compensatory mechanisms. We suggest that age-related 
      differences in gray and white matter properties differentially affect the ability 
      of the brain to engage and coordinate large-scale functional networks that are 
      central to efficient cognitive functioning.
CI  - Crown Copyright (c) 2015. Published by Elsevier Ltd. All rights reserved.
FAU - Marstaller, L
AU  - Marstaller L
AD  - Centre for Advanced Imaging, University of Queensland, Brisbane, Australia; ARC 
      Science of Learning Research Centre, University of Queensland, Brisbane, 
      Australia. Electronic address: l.marstaller@uq.edu.au.
FAU - Williams, M
AU  - Williams M
AD  - Perception in Action Research Centre, Macquarie University, Sydney, Australia; 
      Department of Cognitive Science, Macquarie University, Sydney, Australia; ARC 
      Centre of Excellence in Cognition and its Disorders, Macquarie University, 
      Sydney, Australia.
FAU - Rich, A
AU  - Rich A
AD  - Perception in Action Research Centre, Macquarie University, Sydney, Australia; 
      Department of Cognitive Science, Macquarie University, Sydney, Australia; ARC 
      Centre of Excellence in Cognition and its Disorders, Macquarie University, 
      Sydney, Australia.
FAU - Savage, G
AU  - Savage G
AD  - ARC Centre of Excellence in Cognition and its Disorders, Macquarie University, 
      Sydney, Australia; Department of Psychology, Macquarie University, Sydney, 
      Australia.
FAU - Burianova, H
AU  - Burianova H
AD  - Centre for Advanced Imaging, University of Queensland, Brisbane, Australia; ARC 
      Centre of Excellence in Cognition and its Disorders, Macquarie University, 
      Sydney, Australia.
LA  - eng
PT  - Journal Article
DEP - 20150131
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*pathology/*physiology
MH  - Anisotropy
MH  - Brain/*pathology/*physiology
MH  - Brain Mapping
MH  - Female
MH  - Gray Matter/physiology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neural Pathways/pathology/physiology
MH  - Organ Size
MH  - Rest
MH  - White Matter/pathology/physiology
MH  - Young Adult
OTO - NOTNLM
OT  - aging
OT  - multimodal imaging
OT  - neural plasticity
OT  - resting state networks
OT  - white and gray matter
EDAT- 2015/02/04 06:00
MHDA- 2015/12/17 06:00
CRDT- 2015/02/04 06:00
PHST- 2014/12/16 00:00 [received]
PHST- 2015/01/21 00:00 [revised]
PHST- 2015/01/21 00:00 [accepted]
PHST- 2015/02/04 06:00 [entrez]
PHST- 2015/02/04 06:00 [pubmed]
PHST- 2015/12/17 06:00 [medline]
AID - S0306-4522(15)00105-0 [pii]
AID - 10.1016/j.neuroscience.2015.01.049 [doi]
PST - ppublish
SO  - Neuroscience. 2015 Apr 2;290:369-78. doi: 10.1016/j.neuroscience.2015.01.049. 
      Epub 2015 Jan 31.