PMID- 25645137
OWN - NLM
STAT- MEDLINE
DCOM- 20151123
LR  - 20220309
IS  - 1756-6606 (Electronic)
IS  - 1756-6606 (Linking)
VI  - 8
DP  - 2015 Feb 3
TI  - Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity 
      by activating postsynaptic NMDA receptors.
PG  - 7
LID - 10.1186/s13041-015-0097-y [doi]
LID - 7
AB  - BACKGROUND: Activation of G protein coupled receptor (GPCR) in astrocytes leads 
      to Ca(2+)-dependent glutamate release via Bestrophin 1 (Best1) channel. Whether 
      receptor-mediated glutamate release from astrocytes can regulate synaptic 
      plasticity remains to be fully understood. RESULTS: We show here that 
      Best1-mediated astrocytic glutamate activates the synaptic N-methyl-D-aspartate 
      receptor (NMDAR) and modulates NMDAR-dependent synaptic plasticity. Our data show 
      that activation of the protease-activated receptor 1 (PAR1) in hippocampal CA1 
      astrocytes elevates the glutamate concentration at Schaffer collateral-CA1 
      (SC-CA1) synapses, resulting in activation of GluN2A-containing NMDARs and 
      NMDAR-dependent potentiation of synaptic responses. Furthermore, the threshold 
      for inducing NMDAR-dependent long-term potentiation (LTP) is lowered when 
      astrocytic glutamate release accompanied LTP induction, suggesting that 
      astrocytic glutamate is significant in modulating synaptic plasticity. 
      CONCLUSIONS: Our results provide direct evidence for the physiological importance 
      of channel-mediated astrocytic glutamate in modulating neural circuit functions.
FAU - Park, Hyungju
AU  - Park H
FAU - Han, Kyung-Seok
AU  - Han KS
FAU - Seo, Jinsoo
AU  - Seo J
FAU - Lee, Jaekwang
AU  - Lee J
FAU - Dravid, Shashank M
AU  - Dravid SM
FAU - Woo, Junsung
AU  - Woo J
FAU - Chun, Heejung
AU  - Chun H
FAU - Cho, Sukhee
AU  - Cho S
FAU - Bae, Jin Young
AU  - Bae JY
FAU - An, Heeyoung
AU  - An H
FAU - Koh, Woohyun
AU  - Koh W
FAU - Yoon, Bo-Eun
AU  - Yoon BE
FAU - Berlinguer-Palmini, Rolando
AU  - Berlinguer-Palmini R
FAU - Mannaioni, Guido
AU  - Mannaioni G
FAU - Traynelis, Stephen F
AU  - Traynelis SF
FAU - Bae, Yong Chul
AU  - Bae YC
FAU - Choi, Se-Young
AU  - Choi SY
FAU - Lee, C Justin
AU  - Lee CJ
LA  - eng
GR  - P30 GM110768/GM/NIGMS NIH HHS/United States
GR  - R01 NS039419/NS/NINDS NIH HHS/United States
GR  - NS43875/NS/NINDS NIH HHS/United States
GR  - NS039419/NS/NINDS NIH HHS/United States
GR  - F32 NS043875/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150203
PL  - England
TA  - Mol Brain
JT  - Molecular brain
JID - 101468876
RN  - 0 (Best1 protein, mouse)
RN  - 0 (Bestrophins)
RN  - 0 (Eye Proteins)
RN  - 0 (Ion Channels)
RN  - 0 (Receptor, PAR-1)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 3KX376GY7L (Glutamic Acid)
SB  - IM
EIN - Mol Brain. 2021 Jun 29;14(1):103. PMID: 34187529
MH  - Animals
MH  - Astrocytes/*metabolism
MH  - Bestrophins
MH  - CA1 Region, Hippocampal/metabolism/ultrastructure
MH  - Eye Proteins/*metabolism
MH  - Glutamic Acid/*metabolism
MH  - Hippocampus/*metabolism/ultrastructure
MH  - Humans
MH  - Ion Channels/*metabolism
MH  - Long-Term Potentiation
MH  - Mice
MH  - Models, Biological
MH  - *Neuronal Plasticity
MH  - Receptor, PAR-1/metabolism
MH  - Receptors, N-Methyl-D-Aspartate/*metabolism
MH  - Synapses/metabolism
MH  - Synaptic Transmission
PMC - PMC4320468
EDAT- 2015/02/04 06:00
MHDA- 2015/12/15 06:00
PMCR- 2015/02/03
CRDT- 2015/02/04 06:00
PHST- 2014/12/19 00:00 [received]
PHST- 2015/01/15 00:00 [accepted]
PHST- 2015/02/04 06:00 [entrez]
PHST- 2015/02/04 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2015/02/03 00:00 [pmc-release]
AID - s13041-015-0097-y [pii]
AID - 97 [pii]
AID - 10.1186/s13041-015-0097-y [doi]
PST - epublish
SO  - Mol Brain. 2015 Feb 3;8:7. doi: 10.1186/s13041-015-0097-y.