PMID- 25645274
OWN - NLM
STAT- MEDLINE
DCOM- 20151125
LR  - 20150317
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 41
IP  - 6
DP  - 2015 Mar
TI  - Parietal transcranial direct current stimulation modulates primary motor cortex 
      excitability.
PG  - 845-55
LID - 10.1111/ejn.12840 [doi]
AB  - The posterior parietal cortex is part of the cortical network involved in motor 
      learning and is structurally and functionally connected with the primary motor 
      cortex (M1). Neuroplastic alterations of neuronal connectivity might be an 
      important basis for learning processes. These have however not been explored for 
      parieto-motor connections in humans by transcranial direct current stimulation 
      (tDCS). Exploring tDCS effects on parieto-motor cortical connectivity might be 
      functionally relevant, because tDCS has been shown to improve motor learning. We 
      aimed to explore plastic alterations of parieto-motor cortical connections by 
      tDCS in healthy humans. We measured neuroplastic changes of corticospinal 
      excitability via motor evoked potentials (MEP) elicited by single-pulse 
      transcranial magnetic stimulation (TMS) before and after tDCS over the left 
      posterior parietal cortex (P3), and 3 cm posterior or lateral to P3, to explore 
      the spatial specificity of the effects. Furthermore, short-interval intracortical 
      inhibition/intracortical facilitation (SICI/ICF) over M1, and parieto-motor 
      cortical connectivity were obtained before and after P3 tDCS. The results show 
      polarity-dependent M1 excitability alterations primarily after P3 tDCS. 
      Single-pulse TMS-elicited MEPs, M1 SICI/ICF at 5 and 7 ms and 10 and 15 ms 
      interstimulus intervals (ISIs), and parieto-motor connectivity at 10 and 15 ms 
      ISIs were all enhanced by anodal stimulation. Single pulse-TMS-elicited MEPs, and 
      parieto-motor connectivity at 10 and 15 ms ISIs were reduced by cathodal tDCS. 
      The respective corticospinal excitability alterations lasted for at least 120 min 
      after stimulation. These results show an effect of remote stimulation of parietal 
      areas on M1 excitability. The spatial specificity of the effects and the impact 
      on parietal cortex-motor cortex connections suggest a relevant 
      connectivity-driven effect.
CI  - (c) 2015 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
FAU - Rivera-Urbina, Guadalupe Nathzidy
AU  - Rivera-Urbina GN
AD  - Department of Clinical Neurophysiology, Georg-August-University Gottingen, 
      Gottingen, Germany; University Pablo de Olavide, Ctra. de Utrera, km. 1, Sevilla, 
      41013, Spain.
FAU - Batsikadze, Giorgi
AU  - Batsikadze G
FAU - Molero-Chamizo, Andres
AU  - Molero-Chamizo A
FAU - Paulus, Walter
AU  - Paulus W
FAU - Kuo, Min-Fang
AU  - Kuo MF
FAU - Nitsche, Michael A
AU  - Nitsche MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150203
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
SB  - IM
MH  - Adult
MH  - Evoked Potentials, Motor
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motor Cortex/*physiology
MH  - Neural Inhibition
MH  - *Neuronal Plasticity
MH  - Parietal Lobe/*physiology
MH  - Transcranial Magnetic Stimulation
MH  - Young Adult
OTO - NOTNLM
OT  - motor evoked potential
OT  - plasticity
OT  - short interval intracortical inhibition/intracortical facilitation
OT  - transcranial magnetic stimulation
EDAT- 2015/02/04 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/02/04 06:00
PHST- 2014/10/26 00:00 [received]
PHST- 2014/12/19 00:00 [revised]
PHST- 2014/12/22 00:00 [accepted]
PHST- 2015/02/04 06:00 [entrez]
PHST- 2015/02/04 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.1111/ejn.12840 [doi]
PST - ppublish
SO  - Eur J Neurosci. 2015 Mar;41(6):845-55. doi: 10.1111/ejn.12840. Epub 2015 Feb 3.