PMID- 25648279
OWN - NLM
STAT- MEDLINE
DCOM- 20160317
LR  - 20181202
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Linking)
VI  - 36
IP  - 4
DP  - 2015 Apr
TI  - Longitudinal associations between BDNF promoter methylation and late-life 
      depression.
PG  - 1764.e1-1764.e7
LID - S0197-4580(14)00852-5 [pii]
LID - 10.1016/j.neurobiolaging.2014.12.035 [doi]
AB  - Reduced brain-derived neurotrophic factor (BDNF) function has been suggested as a 
      risk factor for late-life depression. BDNF secretion is influenced by epigenetic 
      (DNA promoter methylation) and genetic (val66met polymorphism) profiles. We 
      investigated the independent and interactive effects of BDNF methylation and 
      val66met polymorphism on late-life depression. In total, 732 Korean community 
      residents aged >/= 65 years were evaluated, and 521 of them without depression at 
      baseline were followed up 2 years later. Depression was determined using the 
      Geriatric Mental State Schedule, and depression severity was evaluated with the 
      Geriatric Depression Scale. Demographic and clinical covariates were obtained. 
      The effects of BDNF methylation and polymorphism on the diagnosis of depression 
      were investigated using a multivariate logistic regression model, and the 
      relationships between BDNF methylation and depression severity were evaluated 
      using partial correlation tests. Higher BDNF methylation was independently 
      associated with the prevalence and incidence of depression and severe depressive 
      symptoms. No significant methylation-genotype interactions were found. BDNF 
      promoter methylation could be a proxy biomarker for depression late in life.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Kang, Hee-Ju
AU  - Kang HJ
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
FAU - Kim, Jae-Min
AU  - Kim JM
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Republic of Korea. Electronic address: jmkim@chonnam.ac.kr.
FAU - Bae, Kyung-Yeol
AU  - Bae KY
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
FAU - Kim, Sung-Wan
AU  - Kim SW
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
FAU - Shin, Il-Seon
AU  - Shin IS
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
FAU - Kim, Hye-Ran
AU  - Kim HR
AD  - Brain Korea 21 Project, Center for Biomedical Human Resources, Chonnam National 
      University Medical School, Gwangju, Republic of Korea.
FAU - Shin, Myung-Geun
AU  - Shin MG
AD  - Department of Laboratory Medicine, Chonnam National University Medical School, 
      Gwangju, Republic of Korea.
FAU - Yoon, Jin-Sang
AU  - Yoon JS
AD  - Department of Psychiatry, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150106
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aged
MH  - Biomarkers
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism/*physiology
MH  - DNA Methylation/*genetics/*physiology
MH  - Depression/diagnosis/epidemiology/*genetics
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Incidence
MH  - Logistic Models
MH  - Male
MH  - Polymorphism, Genetic
MH  - *Promoter Regions, Genetic
MH  - Risk Factors
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Aged
OT  - BDNF
OT  - DNA methylation
OT  - Depression
OT  - Epigenetics
EDAT- 2015/02/05 06:00
MHDA- 2016/03/18 06:00
CRDT- 2015/02/05 06:00
PHST- 2014/01/16 00:00 [received]
PHST- 2014/11/01 00:00 [revised]
PHST- 2014/12/26 00:00 [accepted]
PHST- 2015/02/05 06:00 [entrez]
PHST- 2015/02/05 06:00 [pubmed]
PHST- 2016/03/18 06:00 [medline]
AID - S0197-4580(14)00852-5 [pii]
AID - 10.1016/j.neurobiolaging.2014.12.035 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2015 Apr;36(4):1764.e1-1764.e7. doi: 
      10.1016/j.neurobiolaging.2014.12.035. Epub 2015 Jan 6.