PMID- 25648766
OWN - NLM
STAT- MEDLINE
DCOM- 20151117
LR  - 20230124
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 15
IP  - 3
DP  - 2015 Mar
TI  - Outcomes after heart transplantation for amyloid cardiomyopathy in the modern 
      era.
PG  - 650-8
LID - 10.1111/ajt.13025 [doi]
AB  - We conducted a review of patients undergoing heart transplantation (HT) at our 
      institution for amyloid cardiomyopathy (ACM) between 2008 and 2013. Complete 
      follow-up was available for all patients. Nineteen patients with ACM underwent HT 
      during the study period, accounting for 9.4% of all HT performed at our 
      institution during this period. Amyloid subtype was light chain (AL) in 9 
      patients and transthyretin (ATTR) in 10 (2 wild-type, 7 familial, 1 unknown). 
      Eight of nine patients with AL amyloidosis began chemotherapy prior to HT, six 
      have resumed chemotherapy since HT, and five have undergone autologous stem cell 
      transplantation. Most recent free light chain levels in AL patients decreased by 
      a median of 85% from peak values. Only one patient developed recurrent graft 
      amyloidosis, occurring at 3.5 years post-HT and asymptomatic. After a median 
      follow-up of 380 days, 17 (89.5%) patients are alive. To our knowledge, this is 
      the largest single-center series reported of ACM patients undergoing HT in the 
      modern era. Our results suggest that acceptable outcomes following HT can be 
      achieved in the short-to-intermediate term and that this is a feasible option for 
      end-stage ACM with careful patient selection and aggressive control of 
      amyloidogenic light chains in AL patients.
CI  - (c) Copyright 2015 The American Society of Transplantation and the American Society 
      of Transplant Surgeons.
FAU - Davis, M K
AU  - Davis MK
AD  - Division of Cardiovascular Medicine and Stanford Cardiovascular Institute, 
      Stanford University School of Medicine, Stanford, CA.
FAU - Kale, P
AU  - Kale P
FAU - Liedtke, M
AU  - Liedtke M
FAU - Schrier, S
AU  - Schrier S
FAU - Arai, S
AU  - Arai S
FAU - Wheeler, M
AU  - Wheeler M
FAU - Lafayette, R
AU  - Lafayette R
FAU - Coakley, T
AU  - Coakley T
FAU - Witteles, R M
AU  - Witteles RM
LA  - eng
PT  - Journal Article
DEP - 20150203
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of 
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
SB  - IM
MH  - Aged
MH  - Amyloidosis/*complications
MH  - Cardiomyopathies/complications/*surgery
MH  - Female
MH  - *Heart Transplantation
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Treatment Outcome
OTO - NOTNLM
OT  - clinical research/practice
OT  - heart disease
OT  - heart transplantation/cardiology
OT  - organ procurement and allocation
OT  - patient characteristics
OT  - patient survival
OT  - recipient selection
EDAT- 2015/02/05 06:00
MHDA- 2015/11/18 06:00
CRDT- 2015/02/05 06:00
PHST- 2014/07/15 00:00 [received]
PHST- 2014/09/10 00:00 [revised]
PHST- 2014/09/12 00:00 [accepted]
PHST- 2015/02/05 06:00 [entrez]
PHST- 2015/02/05 06:00 [pubmed]
PHST- 2015/11/18 06:00 [medline]
AID - S1600-6135(22)00126-5 [pii]
AID - 10.1111/ajt.13025 [doi]
PST - ppublish
SO  - Am J Transplant. 2015 Mar;15(3):650-8. doi: 10.1111/ajt.13025. Epub 2015 Feb 3.