PMID- 25649467
OWN - NLM
STAT- MEDLINE
DCOM- 20151120
LR  - 20240322
IS  - 1477-7525 (Electronic)
IS  - 1477-7525 (Linking)
VI  - 13
DP  - 2015 Feb 4
TI  - Preoperative and early postoperative quality of life after major surgery - a 
      prospective observational study.
PG  - 12
LID - 10.1186/s12955-014-0194-0 [doi]
LID - 12
AB  - BACKGROUND: Changes in health-related quality of life (HRQoL) several days after 
      surgery have rarely been investigated. We aimed to estimate the perioperative 
      change of HRQoL, to identify patients with clinically relevant decrease in 
      postoperative HRQoL and to establish factors associated with this decrease in 
      HRQoL at day 30 after major surgery. METHODS: Patients scheduled for major 
      surgery at a university hospital were enrolled. Based on the HRQoL SF-12 
      questionnaire, the preoperative physical component summary (PCS) score, 
      preoperative mental component summary (MCS) score, and postoperative PCS and MCS 
      scores at day 30 were recorded. Minimal clinically important difference (MCID) 
      was defined as those with a decrease of at least one half of the standard 
      deviation (SD) of preoperative PCS or MCS scores. Differences between the groups 
      with or without decreased HRQoL were investigated using univariate comparisons. A 
      multiple logistic regression model was performed to evaluate the predictive value 
      of potential perioperative variables. RESULTS: The mean +/- SD preoperative PCS 
      score was 38.5 +/- 10.6, postoperative score was 35.1 +/- 7.8 (p = .004) in 85 
      patients. Thirty-five patients (41.2%) had a clinically relevant decrease of the 
      postoperative PCS score. A normal to high preoperative exercise metabolic 
      capacity measured with metabolic equivalent of task (MET) (p = .01) was a 
      predictor of the decrease in postoperative PCS. The mean preoperative MCS scores 
      (p = .395) were 42.2 (SD 12.8) preoperative, and 43.45 (SD 12.4) postoperative, 
      respectively. CONCLUSIONS: Major surgery decreases postoperative PCS scores of 
      HRQoL at 30 days. A normal to high exercise capacity was a predictor of a 
      clinically relevant decrease of postoperative PCS scores. TRIAL REGISTRATION: 
      07-107 (Ethical Committee NAC of Geneva University Hospitals).
FAU - Maillard, Julien
AU  - Maillard J
AD  - Division of Anesthesiology, University Hospitals of Geneva, Rue 
      Gabrielle-Perret-Gentil 4 - 1206, Geneva, Switzerland. julien.maillard@hcuge.ch.
FAU - Elia, Nadia
AU  - Elia N
AD  - Division of Anesthesiology, University Hospitals of Geneva, Rue 
      Gabrielle-Perret-Gentil 4 - 1206, Geneva, Switzerland. nadia.elia@hcuge.ch.
AD  - Institute of Social and Preventive Medicine, Medical Faculty, University of 
      Geneva, Chemin de la Tour de Champel 17 - 1206, Geneva, Switzerland. 
      nadia.elia@hcuge.ch.
FAU - Haller, Chiara S
AU  - Haller CS
AD  - Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts 
      Mental Health Center, Harvard Medical School, 330 Brookline Avenue, Boston, 
      02215, MA, USA. haller@fas.harvard.edu.
AD  - Department of Psychology, Harvard University, Cambridge, 02138, MA, USA. 
      haller@fas.harvard.edu.
FAU - Delhumeau, Cecile
AU  - Delhumeau C
AD  - Division of Anesthesiology, University Hospitals of Geneva, Rue 
      Gabrielle-Perret-Gentil 4 - 1206, Geneva, Switzerland. 
      cecile.delhumeau@gmail.com.
FAU - Walder, Bernhard
AU  - Walder B
AD  - Division of Anesthesiology, University Hospitals of Geneva, Rue 
      Gabrielle-Perret-Gentil 4 - 1206, Geneva, Switzerland. bernhard.walder@hcuge.ch.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
DEP - 20150204
PL  - England
TA  - Health Qual Life Outcomes
JT  - Health and quality of life outcomes
JID - 101153626
SB  - IM
MH  - Aged
MH  - Cohort Studies
MH  - Female
MH  - General Surgery/*statistics & numerical data
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Models, Psychological
MH  - Models, Statistical
MH  - Outcome Assessment, Health Care
MH  - Pain, Postoperative/*psychology
MH  - Postoperative Complications/*psychology
MH  - Postoperative Period
MH  - Preoperative Period
MH  - Prospective Studies
MH  - Quality of Life/*psychology
MH  - Surveys and Questionnaires
MH  - Switzerland
PMC - PMC4333246
EDAT- 2015/02/05 06:00
MHDA- 2015/12/15 06:00
PMCR- 2015/02/04
CRDT- 2015/02/05 06:00
PHST- 2014/08/23 00:00 [received]
PHST- 2014/12/16 00:00 [accepted]
PHST- 2015/02/05 06:00 [entrez]
PHST- 2015/02/05 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2015/02/04 00:00 [pmc-release]
AID - s12955-014-0194-0 [pii]
AID - 194 [pii]
AID - 10.1186/s12955-014-0194-0 [doi]
PST - epublish
SO  - Health Qual Life Outcomes. 2015 Feb 4;13:12. doi: 10.1186/s12955-014-0194-0.