PMID- 25650137
OWN - NLM
STAT- MEDLINE
DCOM- 20151120
LR  - 20220129
IS  - 1873-6823 (Electronic)
IS  - 0741-8329 (Linking)
VI  - 49
IP  - 2
DP  - 2015 Mar
TI  - BDNF Val66Met and reward-related brain function in adolescents: role for early 
      alcohol consumption.
PG  - 103-10
LID - S0741-8329(14)20200-X [pii]
LID - 10.1016/j.alcohol.2014.12.004 [doi]
AB  - Changes in reward processing have been identified as one important pathogenetic 
      mechanism in alcohol addiction. The nonsynonymous single nucleotide polymorphism 
      in the brain-derived neurotrophic factor (BDNF) gene (rs6265/Val66Met) modulates 
      the central nervous system activity of neurotransmitters involved in reward 
      processing such as serotonin, dopamine, and glutamate. It was identified as 
      crucial for alcohol consumption in healthy adults and, in rats, specifically 
      related to the function in the striatum, a region that is commonly involved in 
      reward processing. However, studies in humans on the association of BDNF Val66Met 
      and reward-related brain functions and its role for alcohol consumption, a 
      significant predictor of later alcohol addiction, are missing. Based on an 
      intermediate phenotype approach, we assessed the early orientation toward alcohol 
      and alcohol consumption in 530 healthy adolescents that underwent a monetary 
      incentive delay task during functional magnetic resonance imaging. We found a 
      significantly lower response in the putamen to reward anticipation in adolescent 
      Met carriers with high versus low levels of alcohol consumption. During reward 
      feedback, Met carriers with low putamen reactivity were significantly more likely 
      to orient toward alcohol and to drink alcohol 2 years later. This study indicates 
      a possible effect of BDNF Val66Met on alcohol addiction-related phenotypes in 
      adolescence.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Nees, F
AU  - Nees F
AD  - Department of Cognitive and Clinical Neuroscience, Central Institute of Mental 
      Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. 
      Electronic address: frauke.nees@zi-mannheim.de.
FAU - Witt, S H
AU  - Witt SH
AD  - Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental 
      Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
FAU - Dinu-Biringer, R
AU  - Dinu-Biringer R
AD  - Department of Cognitive and Clinical Neuroscience, Central Institute of Mental 
      Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; 
      Department of Clinical Psychology and Psychotherapy, Ruprecht-Karls University 
      Heidelberg, Heidelberg, Germany.
FAU - Lourdusamy, A
AU  - Lourdusamy A
AD  - Institute of Psychiatry, King's College London, United Kingdom; MRC Social, 
      Genetic and Developmental Psychiatry (SGDP) Centre, London, United Kingdom.
FAU - Tzschoppe, J
AU  - Tzschoppe J
AD  - Department of Cognitive and Clinical Neuroscience, Central Institute of Mental 
      Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
FAU - Vollstadt-Klein, S
AU  - Vollstadt-Klein S
AD  - Department of Addictive Behaviour and Addiction Medicine, Central Institute of 
      Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, 
      Germany.
FAU - Millenet, S
AU  - Millenet S
AD  - Department of Child and Adolescent Psychiatry and Psychotherapy, Central 
      Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 
      Mannheim, Germany.
FAU - Bach, C
AU  - Bach C
AD  - Department of Child and Adolescent Psychiatry and Psychotherapy, Central 
      Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 
      Mannheim, Germany.
FAU - Poustka, L
AU  - Poustka L
AD  - Department of Child and Adolescent Psychiatry and Psychotherapy, Central 
      Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 
      Mannheim, Germany.
FAU - Banaschewski, T
AU  - Banaschewski T
AD  - Department of Child and Adolescent Psychiatry and Psychotherapy, Central 
      Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 
      Mannheim, Germany.
FAU - Barker, G J
AU  - Barker GJ
AD  - Institute of Psychiatry, King's College London, United Kingdom.
FAU - Bokde, A L W
AU  - Bokde AL
AD  - Institute of Neuroscience and Discipline of Psychiatry, School of Medicine, 
      Trinity College Dublin, Dublin, Ireland.
FAU - Bromberg, U
AU  - Bromberg U
AD  - NeuroImage Nord, Department of Systems Neuroscience, University Medical Center 
      Hamburg-Eppendorf, Germany.
FAU - Buchel, C
AU  - Buchel C
AD  - NeuroImage Nord, Department of Systems Neuroscience, University Medical Center 
      Hamburg-Eppendorf, Germany.
FAU - Conrod, P J
AU  - Conrod PJ
AD  - Institute of Psychiatry, King's College London, United Kingdom; Department of 
      Psychiatry, Universite de Montreal, CHU Ste Justine Hospital, Canada.
FAU - Frank, J
AU  - Frank J
AD  - Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental 
      Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
FAU - Frouin, V
AU  - Frouin V
AD  - Neurospin, Commissariat a l'Energie Atomique et aux Energies Alternatives, Paris, 
      France.
FAU - Gallinat, J
AU  - Gallinat J
AD  - Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Charite - 
      Universitatsmedizin Berlin, Berlin, Germany.
FAU - Garavan, H
AU  - Garavan H
AD  - Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland; Department of 
      Psychiatry, University of Vermont, USA; Department of Psychology, University of 
      Vermont, USA.
FAU - Gowland, P
AU  - Gowland P
AD  - School of Physics and Astronomy, University of Nottingham, United Kingdom.
FAU - Heinz, A
AU  - Heinz A
AD  - Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Charite - 
      Universitatsmedizin Berlin, Berlin, Germany.
FAU - Ittermann, B
AU  - Ittermann B
AD  - Physikalisch-Technische Bundesanstalt, Berlin, Germany.
FAU - Mann, K
AU  - Mann K
AD  - Department of Addictive Behaviour and Addiction Medicine, Central Institute of 
      Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, 
      Germany.
FAU - Martinot, J-L
AU  - Martinot JL
AD  - INSERM CEA Unit 1000 "Imaging & Psychiatry", Institut National de la Sante et de 
      la Recherche Medicale, University Paris Sud, Orsay, France; AP-HP Department of 
      Adolescent Psychopathology and Medicine, Maison de Solenn, University Paris 
      Descartes, Paris, France.
FAU - Paus, T
AU  - Paus T
AD  - Rotman Research Institute, University of Toronto, Toronto, Canada; Montreal 
      Neurological Institute, McGill University, QC, Canada.
FAU - Pausova, Z
AU  - Pausova Z
AD  - The Hospital for Sick Children, Department of Physiology and Nutritional 
      Sciences, University of Toronto, Toronto, Canada.
FAU - Robbins, T W
AU  - Robbins TW
AD  - Behavioural and Clinical Neurosciences Institute, Department of Experimental 
      Psychology, University of Cambridge, United Kingdom.
FAU - Smolka, M N
AU  - Smolka MN
AD  - Department of Psychiatry and Psychotherapy, Neuroimaging Center, Technische 
      Universitaet Dresden, Dresden, Germany.
FAU - Rietschel, M
AU  - Rietschel M
AD  - Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental 
      Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
FAU - Schumann, G
AU  - Schumann G
AD  - Institute of Psychiatry, King's College London, United Kingdom; MRC Social, 
      Genetic and Developmental Psychiatry (SGDP) Centre, London, United Kingdom.
FAU - Flor, H
AU  - Flor H
AD  - Department of Cognitive and Clinical Neuroscience, Central Institute of Mental 
      Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
CN  - IMAGEN consortium
LA  - eng
GR  - G0001354/MRC_/Medical Research Council/United Kingdom
GR  - G0901858/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20150107
PL  - United States
TA  - Alcohol
JT  - Alcohol (Fayetteville, N.Y.)
JID - 8502311
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adolescent
MH  - Adolescent Behavior/*physiology/psychology
MH  - Alcohol Drinking/*genetics/psychology
MH  - Brain/*physiology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Methionine/genetics
MH  - *Reward
MH  - Valine/genetics
OTO - NOTNLM
OT  - Adolescence
OT  - Alcohol
OT  - BDNF gene
OT  - Reward
OT  - Striatum
EDAT- 2015/02/05 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/02/05 06:00
PHST- 2014/10/01 00:00 [received]
PHST- 2014/12/22 00:00 [revised]
PHST- 2014/12/22 00:00 [accepted]
PHST- 2015/02/05 06:00 [entrez]
PHST- 2015/02/05 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S0741-8329(14)20200-X [pii]
AID - 10.1016/j.alcohol.2014.12.004 [doi]
PST - ppublish
SO  - Alcohol. 2015 Mar;49(2):103-10. doi: 10.1016/j.alcohol.2014.12.004. Epub 2015 Jan 
      7.