PMID- 25650419
OWN - NLM
STAT- MEDLINE
DCOM- 20150903
LR  - 20220310
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 56
IP  - 3
DP  - 2015 Feb 3
TI  - The association between subjective and objective parameters for the assessment of 
      dry-eye syndrome.
PG  - 1467-72
LID - 10.1167/iovs.14-15814 [doi]
AB  - PURPOSE: The aim of the present study was to evaluate the association between 
      symptoms and different clinical signs in patients with dry-eye syndrome (DES). 
      METHODS: Fifty-two patients with DES were included in the present cross-sectional 
      study. For assessment of symptoms, the Ocular Surface Disease Index (OSDI) was 
      used. Clinical parameters included measurement of tear break up time (BUT), 
      corneal fluorescein staining, tear osmolarity, and ocular scattering index (OSI). 
      Tear film thickness (TFT) was assessed using a custom-built optical coherence 
      tomography (OCT) system with an axial resolution of 1.2 mum. In addition, 
      impression cytology was performed. Correlation coefficients were calculated using 
      linear regression analysis. RESULTS: The mean OSDI in the present study 
      population was 28.9 +/- 17.6, the mean TFT was 4.1 +/- 1.3 mum. A significant negative 
      correlation was found between OSDI and TFT (r = -0.34, P = 0.01). Tear film 
      thickness correlated positively with BUT (r = 0.35, P = 0.01), but with no other 
      signs of DES. No association was found between OSDI and the other evaluated 
      signs. CONCLUSIONS: The study population mainly comprised of patients with mild 
      to moderate DES. Tear film thickness as measured with a custom-built OCT device 
      correlated with subjective symptoms in these patients. In agreement with previous 
      data, the association between other signs and symptoms was weak in the present 
      study. Measurement of TFT with OCT may become a valuable tool in the management 
      of DES patients. (ClinicalTrials.gov number, NCT01753687.)
CI  - Copyright 2015 The Association for Research in Vision and Ophthalmology, Inc.
FAU - Schmidl, Doreen
AU  - Schmidl D
AD  - Department of Clinical Pharmacology, Medical University of Vienna, Austria Center 
      for Medical Physics and Biomedical Engineering, Medical University of Vienna, 
      Austria.
FAU - Witkowska, Katarzyna Jadwiga
AU  - Witkowska KJ
AD  - Department of Clinical Pharmacology, Medical University of Vienna, Austria.
FAU - Kaya, Semira
AU  - Kaya S
AD  - Department of Ophthalmology, Paracelsus Medical University, Salzburg, Austria.
FAU - Baar, Carina
AU  - Baar C
AD  - Department of Clinical Pharmacology, Medical University of Vienna, Austria.
FAU - Faatz, Henrik
AU  - Faatz H
AD  - Department of Clinical Pharmacology, Medical University of Vienna, Austria.
FAU - Nepp, Johannes
AU  - Nepp J
AD  - Department of Ophthalmology and Optometry, Medical University of Vienna, Austria.
FAU - Unterhuber, Angelika
AU  - Unterhuber A
AD  - Center for Medical Physics and Biomedical Engineering, Medical University of 
      Vienna, Austria.
FAU - Werkmeister, Rene Marcel
AU  - Werkmeister RM
AD  - Center for Medical Physics and Biomedical Engineering, Medical University of 
      Vienna, Austria.
FAU - Garhofer, Gerhard
AU  - Garhofer G
AD  - Department of Clinical Pharmacology, Medical University of Vienna, Austria.
FAU - Schmetterer, Leopold
AU  - Schmetterer L
AD  - Department of Clinical Pharmacology, Medical University of Vienna, Austria Center 
      for Medical Physics and Biomedical Engineering, Medical University of Vienna, 
      Austria.
LA  - eng
SI  - ClinicalTrials.gov/NCT01753687
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150203
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Dry Eye Syndromes/*diagnosis/physiopathology
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Male
MH  - Middle Aged
MH  - Reference Values
MH  - Tears/physiology
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
OTO - NOTNLM
OT  - corneal fluorescein staining
OT  - dry-eye syndrome
OT  - impression cytology
OT  - objective scattering index
OT  - ocular surface disease index
OT  - optical coherence tomography
OT  - tear break up time
OT  - tear film thickness
OT  - tear osmolarity
EDAT- 2015/02/05 06:00
MHDA- 2015/09/04 06:00
CRDT- 2015/02/05 06:00
PHST- 2015/02/05 06:00 [entrez]
PHST- 2015/02/05 06:00 [pubmed]
PHST- 2015/09/04 06:00 [medline]
AID - iovs.14-15814 [pii]
AID - 10.1167/iovs.14-15814 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2015 Feb 3;56(3):1467-72. doi: 10.1167/iovs.14-15814.