PMID- 25651370
OWN - NLM
STAT- MEDLINE
DCOM- 20150622
LR  - 20150803
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Linking)
VI  - 349
IP  - 4
DP  - 2015 Apr
TI  - Association of HLA-DR/DQ polymorphism with Alzheimer's disease.
PG  - 334-7
LID - 10.1097/MAJ.0000000000000416 [doi]
AB  - BACKGROUND: Alzheimer's disease (AD) is a complex disorder, resulting from an 
      interaction between environmental and genetic factors. Several studies have 
      addressed the association of AD with major histocompatibility complex (MHC) 
      polymorphisms without arriving at any definite conclusions. The human leukocyte 
      antigen (HLA) region is the key susceptibility locus in many immunological 
      diseases. The aim of this study was to investigate the probable association 
      between HLA-DR/DQ alleles and AD in Tunisian patients. METHODS: HLA-DR/DQ 
      genotyping was performed using polymerase chain reaction sequence-specific 
      primers with 55 AD patients and 100 healthy individuals serving as the control 
      group. RESULTS: AD in Tunisian patients was found to be associated with the 
      following alleles (Pc denotes Bonferroni corrected probability values): 
      HLA-DRB1*15 (Pc < 10-3), DRB1*04 (Pc = 0.03) and DQB1*06 (Pc < 10-3). Two 
      haplotypes found to be associated with the disease were DRB1*1501/DQB1*0602 (Pc < 
      10-3) and DRB1*0402/DQB1*0302 (Pc = 0.02). CONCLUSIONS: The authors believe this 
      to be the first research linking the haplotypes DRB1*1501/DQB1*0602 and 
      DRB1*04/DQB1*0302 with AD. Larger studies in other populations will be important 
      to support the present findings of the possible susceptible risk of HLA-DR/DQ in 
      AD.
FAU - Mansouri, Leila
AU  - Mansouri L
AD  - Laboratory of Molecular Biology (LM, SK, NG, NF-M), Department of Hematology, 
      Military Hospital, Tunis, Tunisia; and Department of Neurology (MM, IB, HD, RM), 
      Military Hospital, Tunis, Tunisia.
FAU - Messalmani, Mariem
AU  - Messalmani M
FAU - Klai, Sarra
AU  - Klai S
FAU - Bedoui, Ines
AU  - Bedoui I
FAU - Derbali, Hajer
AU  - Derbali H
FAU - Gritli, Nasreddine
AU  - Gritli N
FAU - Mrissa, Ridha
AU  - Mrissa R
FAU - Fekih-Mrissa, Najiba
AU  - Fekih-Mrissa N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Alzheimer Disease/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains/genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains/genetics
MH  - Haplotypes/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
EDAT- 2015/02/05 06:00
MHDA- 2015/06/24 06:00
CRDT- 2015/02/05 06:00
PHST- 2015/02/05 06:00 [entrez]
PHST- 2015/02/05 06:00 [pubmed]
PHST- 2015/06/24 06:00 [medline]
AID - S0002-9629(15)30069-0 [pii]
AID - 10.1097/MAJ.0000000000000416 [doi]
PST - ppublish
SO  - Am J Med Sci. 2015 Apr;349(4):334-7. doi: 10.1097/MAJ.0000000000000416.