PMID- 25652181
OWN - NLM
STAT- MEDLINE
DCOM- 20150318
LR  - 20220318
IS  - 1942-0080 (Electronic)
IS  - 1941-9651 (Print)
IS  - 1941-9651 (Linking)
VI  - 8
IP  - 2
DP  - 2015 Feb
TI  - Association of left atrial function and left atrial enhancement in patients with 
      atrial fibrillation: cardiac magnetic resonance study.
PG  - e002769
LID - 10.1161/CIRCIMAGING.114.002769 [doi]
LID - 10.1161/CIRCIMAGING.114.002769 e002769
AB  - BACKGROUND: Atrial fibrillation (AF) is associated with left atrial (LA) 
      structural and functional changes. Cardiac magnetic resonance late gadolinium 
      enhancement (LGE) and feature-tracking are capable of noninvasive quantification 
      of LA fibrosis and myocardial motion, respectively. We sought to examine the 
      association of phasic LA function with LA enhancement in patients with AF. 
      METHODS AND RESULTS: LA structure and function was measured in 90 patients with 
      AF (age 61+/-10 years; 76% men) referred for ablation and 14 healthy volunteers. 
      Peak global longitudinal LA strain, LA systolic strain rate, and early and late 
      diastolic strain rates were measured using cine-cardiac magnetic resonance images 
      acquired during sinus rhythm. The degree of LGE was quantified. Compared with 
      patients with paroxysmal AF (60% of cohort), those with persistent AF had larger 
      maximum LA volume index (56+/-17 versus 49+/-13 mL/m(2); P=0.036), and increased LGE 
      (27.1+/-11.7% versus 36.8+/-14.8%; P<0.001). Aside from LA active emptying fraction, 
      all LA parameters (passive emptying fraction, peak global longitudinal LA strain, 
      systolic strain rate, early diastolic strain rate, and late diastolic strain 
      rate) were lower in patients with persistent AF (P<0.05 for all). Healthy 
      volunteers had less LGE and higher LA functional parameters compared with 
      patients with AF (P<0.05 for all). In multivariable analysis, increased LGE was 
      associated with lower LA passive emptying fraction, peak global longitudinal LA 
      strain, systolic strain rate, early diastolic strain rate, and late diastolic 
      strain rate (P<0.05 for all). CONCLUSIONS: Increased LA enhancement is associated 
      with decreased LA reservoir, conduit, and booster pump functions. Phasic 
      measurement of LA function using feature-tracking cardiac magnetic resonance may 
      add important information about the physiological importance of LA fibrosis.
CI  - (c) 2015 American Heart Association, Inc.
FAU - Habibi, Mohammadali
AU  - Habibi M
AD  - From the Department of Cardiology (M.H., J.A.C.L., I.M.K., K.F., D.S., H.A., 
      J.R., J.E.M., H.C., S.N.), Department of Radiology (S.L.Z.), The Johns Hopkins 
      University School of Medicine, Baltimore, MD; and Department of Biostatistics 
      (V.Z.), Department of Epidemiology (S.N.), The Johns Hopkins Bloomberg School of 
      Public Health, Baltimore, MD. mhabibi3@jhmi.edu.
FAU - Lima, Joao A C
AU  - Lima JA
AD  - From the Department of Cardiology (M.H., J.A.C.L., I.M.K., K.F., D.S., H.A., 
      J.R., J.E.M., H.C., S.N.), Department of Radiology (S.L.Z.), The Johns Hopkins 
      University School of Medicine, Baltimore, MD; and Department of Biostatistics 
      (V.Z.), Department of Epidemiology (S.N.), The Johns Hopkins Bloomberg School of 
      Public Health, Baltimore, MD.
FAU - Khurram, Irfan M
AU  - Khurram IM
AD  - From the Department of Cardiology (M.H., J.A.C.L., I.M.K., K.F., D.S., H.A., 
      J.R., J.E.M., H.C., S.N.), Department of Radiology (S.L.Z.), The Johns Hopkins 
      University School of Medicine, Baltimore, MD; and Department of Biostatistics 
      (V.Z.), Department of Epidemiology (S.N.), The Johns Hopkins Bloomberg School of 
      Public Health, Baltimore, MD.
FAU - Zimmerman, Stefan L
AU  - Zimmerman SL
AD  - From the Department of Cardiology (M.H., J.A.C.L., I.M.K., K.F., D.S., H.A., 
      J.R., J.E.M., H.C., S.N.), Department of Radiology (S.L.Z.), The Johns Hopkins 
      University School of Medicine, Baltimore, MD; and Department of Biostatistics 
      (V.Z.), Department of Epidemiology (S.N.), The Johns Hopkins Bloomberg School of 
      Public Health, Baltimore, MD.
FAU - Zipunnikov, Vadim
AU  - Zipunnikov V
AD  - From the Department of Cardiology (M.H., J.A.C.L., I.M.K., K.F., D.S., H.A., 
      J.R., J.E.M., H.C., S.N.), Department of Radiology (S.L.Z.), The Johns Hopkins 
      University School of Medicine, Baltimore, MD; and Department of Biostatistics 
      (V.Z.), Department of Epidemiology (S.N.), The Johns Hopkins Bloomberg School of 
      Public Health, Baltimore, MD.
FAU - Fukumoto, Kotaro
AU  - Fukumoto K
AD  - From the Department of Cardiology (M.H., J.A.C.L., I.M.K., K.F., D.S., H.A., 
      J.R., J.E.M., H.C., S.N.), Department of Radiology (S.L.Z.), The Johns Hopkins 
      University School of Medicine, Baltimore, MD; and Department of Biostatistics 
      (V.Z.), Department of Epidemiology (S.N.), The Johns Hopkins Bloomberg School of 
      Public Health, Baltimore, MD.
FAU - Spragg, David
AU  - Spragg D
AD  - From the Department of Cardiology (M.H., J.A.C.L., I.M.K., K.F., D.S., H.A., 
      J.R., J.E.M., H.C., S.N.), Department of Radiology (S.L.Z.), The Johns Hopkins 
      University School of Medicine, Baltimore, MD; and Department of Biostatistics 
      (V.Z.), Department of Epidemiology (S.N.), The Johns Hopkins Bloomberg School of 
      Public Health, Baltimore, MD.
FAU - Ashikaga, Hiroshi
AU  - Ashikaga H
AD  - From the Department of Cardiology (M.H., J.A.C.L., I.M.K., K.F., D.S., H.A., 
      J.R., J.E.M., H.C., S.N.), Department of Radiology (S.L.Z.), The Johns Hopkins 
      University School of Medicine, Baltimore, MD; and Department of Biostatistics 
      (V.Z.), Department of Epidemiology (S.N.), The Johns Hopkins Bloomberg School of 
      Public Health, Baltimore, MD.
FAU - Rickard, John
AU  - Rickard J
AD  - From the Department of Cardiology (M.H., J.A.C.L., I.M.K., K.F., D.S., H.A., 
      J.R., J.E.M., H.C., S.N.), Department of Radiology (S.L.Z.), The Johns Hopkins 
      University School of Medicine, Baltimore, MD; and Department of Biostatistics 
      (V.Z.), Department of Epidemiology (S.N.), The Johns Hopkins Bloomberg School of 
      Public Health, Baltimore, MD.
FAU - Marine, Joseph E
AU  - Marine JE
AD  - From the Department of Cardiology (M.H., J.A.C.L., I.M.K., K.F., D.S., H.A., 
      J.R., J.E.M., H.C., S.N.), Department of Radiology (S.L.Z.), The Johns Hopkins 
      University School of Medicine, Baltimore, MD; and Department of Biostatistics 
      (V.Z.), Department of Epidemiology (S.N.), The Johns Hopkins Bloomberg School of 
      Public Health, Baltimore, MD.
FAU - Calkins, Hugh
AU  - Calkins H
AD  - From the Department of Cardiology (M.H., J.A.C.L., I.M.K., K.F., D.S., H.A., 
      J.R., J.E.M., H.C., S.N.), Department of Radiology (S.L.Z.), The Johns Hopkins 
      University School of Medicine, Baltimore, MD; and Department of Biostatistics 
      (V.Z.), Department of Epidemiology (S.N.), The Johns Hopkins Bloomberg School of 
      Public Health, Baltimore, MD.
FAU - Nazarian, Saman
AU  - Nazarian S
AD  - From the Department of Cardiology (M.H., J.A.C.L., I.M.K., K.F., D.S., H.A., 
      J.R., J.E.M., H.C., S.N.), Department of Radiology (S.L.Z.), The Johns Hopkins 
      University School of Medicine, Baltimore, MD; and Department of Biostatistics 
      (V.Z.), Department of Epidemiology (S.N.), The Johns Hopkins Bloomberg School of 
      Public Health, Baltimore, MD.
LA  - eng
GR  - K23 HL089333/HL/NHLBI NIH HHS/United States
GR  - R01 HL116280/HL/NHLBI NIH HHS/United States
GR  - K23HL089333/HL/NHLBI NIH HHS/United States
GR  - R01HL116280/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Circ Cardiovasc Imaging
JT  - Circulation. Cardiovascular imaging
JID - 101479935
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Atrial Fibrillation/*diagnosis/pathology/physiopathology
MH  - *Atrial Function, Left
MH  - *Atrial Remodeling
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Contrast Media
MH  - Female
MH  - Fibrosis
MH  - Gadolinium DTPA
MH  - Heart Atria/pathology/physiopathology
MH  - Humans
MH  - Linear Models
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Predictive Value of Tests
PMC - PMC4319560
MID - NIHMS655444
OTO - NOTNLM
OT  - atrial fibrillation
OT  - atrial function, left
OT  - gadolinium
OT  - magnetic resonance imaging
EDAT- 2015/02/06 06:00
MHDA- 2015/03/19 06:00
PMCR- 2016/02/01
CRDT- 2015/02/06 06:00
PHST- 2015/02/06 06:00 [entrez]
PHST- 2015/02/06 06:00 [pubmed]
PHST- 2015/03/19 06:00 [medline]
PHST- 2016/02/01 00:00 [pmc-release]
AID - CIRCIMAGING.114.002769 [pii]
AID - 10.1161/CIRCIMAGING.114.002769 [doi]
PST - ppublish
SO  - Circ Cardiovasc Imaging. 2015 Feb;8(2):e002769. doi: 
      10.1161/CIRCIMAGING.114.002769.