PMID- 25653686 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20150205 LR - 20200930 IS - 1738-1061 (Print) IS - 2092-7258 (Electronic) IS - 1738-1061 (Linking) VI - 57 IP - 12 DP - 2014 Dec TI - Associations of matrix metalloproteinase (MMP)-8, MMP-9, and their inhibitor, tissue inhibitor of metalloproteinase-1, with obesity-related biomarkers in apparently healthy adolescent boys. PG - 526-32 LID - 10.3345/kjp.2014.57.12.526 [doi] AB - PURPOSE: Matrix metalloproteinases (MMPs) have been implicated in atherosclerosis, and therefore, are considered risk factors for metabolic dysfunction in adults. However, there is little data on circulating levels of MMPs and tissue inhibitors of MMPs (TIMPs) with regard to obesity-related biomarkers in the general adolescent population. In the present study, we determined the associations of MMP-8, MMP-9, and TIMP-1 levels and MMP-8/TIMP-1 and MMP-9/TIMP-1 ratios with obesity-related biomarkers in apparently healthy adolescent boys. METHODS: We measured MMP and TIMP concentrations in plasma samples using the enzyme-linked immunosorbent assay and analyzed their associations with obesity-related biomarkers, such as liver enzymes and lipid profiles, in a sample of 91 Korean boys aged 13-14 years who participated in a general health check-up. RESULTS: The mean age of the boys was 13.8+/-0.3 years; 72 boys were normal weight and 19 were overweight/obese. The Pearson correlation coefficients revealed a significant correlation between MMP-8 and aspartate aminotransferase (r=0.217, P=0.039) and alanine aminotransferase (r=0.250, P=0.017) and between TIMP-1 and aspartate aminotransferase (r=0.267, P=0.011). In a multivariate linear regression analysis, serum alanine aminotransferase was positively associated with the MMP-8 level. There were no significant differences in the MMP-8, MMP-9, and TIMP-1 levels or MMP-8/TIMP-1 and MMP-9/TIMP-1 ratios between control and overweight/obese subjects. CONCLUSION: We found a significant association between the MMP-8 level and alanine aminotransferase in the apparently healthy adolescent boys. These findings indicate that there may be a pathophysiological mechanism underlying the relationship between MMP-8 and liver enzymes in young adolescents. FAU - Shin, Youn Ho AU - Shin YH AD - Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea. ; Department of Medicine, The Graduate School, Yonsei University, Seoul, Korea. FAU - Kim, Ki Eun AU - Kim KE AD - Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea. FAU - Lee, Yong-Jae AU - Lee YJ AD - Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea. FAU - Nam, Jae-Hwan AU - Nam JH AD - Department of Biotechnology, The Catholic University of Korea, Bucheon St. Mary's Hospital, Bucheon, Korea. FAU - Hong, Young Mi AU - Hong YM AD - Department of Pediatrics, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Korea. FAU - Shin, Hye-Jung AU - Shin HJ AD - Department of Pediatrics, National Medical Center, Seoul, Korea. LA - eng PT - Journal Article DEP - 20141231 PL - Korea (South) TA - Korean J Pediatr JT - Korean journal of pediatrics JID - 101215374 PMC - PMC4316596 OTO - NOTNLM OT - Adolescent OT - Alanine aminotransferase OT - Matrix metalloproteinases OT - Overweight OT - Tissue inhibitor of metalloproteinase COIS- No potential conflict of interest relevant to this article was reported. EDAT- 2015/02/06 06:00 MHDA- 2015/02/06 06:01 PMCR- 2014/12/01 CRDT- 2015/02/06 06:00 PHST- 2014/01/29 00:00 [received] PHST- 2014/07/15 00:00 [revised] PHST- 2014/08/29 00:00 [accepted] PHST- 2015/02/06 06:00 [entrez] PHST- 2015/02/06 06:00 [pubmed] PHST- 2015/02/06 06:01 [medline] PHST- 2014/12/01 00:00 [pmc-release] AID - 10.3345/kjp.2014.57.12.526 [doi] PST - ppublish SO - Korean J Pediatr. 2014 Dec;57(12):526-32. doi: 10.3345/kjp.2014.57.12.526. Epub 2014 Dec 31.