PMID- 25655064
OWN - NLM
STAT- MEDLINE
DCOM- 20150818
LR  - 20151015
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Linking)
VI  - 101
IP  - 12
DP  - 2015 Jun
TI  - Long-term outcome after transcatheter aortic valve implantation.
PG  - 936-42
LID - 10.1136/heartjnl-2014-306694 [doi]
AB  - OBJECTIVE: To assess late outcome after transcatheter aortic valve implantation 
      (TAVI) up to 6 years and to analyse its predictive factors with a particular 
      emphasis on functional status. Very few data exist on the long-term results of 
      TAVI, and these data are crucial for decision making. METHODS: Between October 
      2006 and December 2009, 123 consecutive patients were discharged alive after TAVI 
      in our institution. Mean age was 82+/-8 years, and 88% of patients were highly 
      symptomatic in New York Heart Association (NYHA) class III-IV. RESULTS: Follow-up 
      was complete in 122 patients (99%). The overall 6-year survival rate was 31%+/-5%, 
      the majority of deaths being non-cardiac. Predictive factors of late mortality 
      were the presence of lower limb arteritis (p=0.009), a higher Charlson 
      comorbidity index (p=0.03) and post-TAVI paraprosthetic aortic regurgitation >/=2/4 
      (p=0.01). Late outcomes according to Valve Academic Research Consortium-2 
      criteria were analysed, and the 5-year event-free survival rate was 28%+/-4%. 
      Finally, the rate of good functional results, defined as survival in NYHA class I 
      or II, was 32%+/-5% at 5-year follow-up. In the survivors, the EQ-5D questionnaire 
      further confirmed the benefit in terms of quality of life. CONCLUSIONS: About 
      one-third of patients discharged alive after TAVI were alive at 6-year follow-up, 
      and the survivors exhibited good functional results assessed by NYHA class and 
      quality-of-life standardised evaluation.
CI  - Published by the BMJ Publishing Group Limited. For permission to use (where not 
      already granted under a licence) please go to 
      http://group.bmj.com/group/rights-licensing/permissions.
FAU - Bouleti, Claire
AU  - Bouleti C
AD  - Department of Cardiology, Assistance Publique-Hopitaux de Paris, Bichat Hospital, 
      Paris, France Faculte de Medecine Paris-Diderot University Paris 7, Paris, 
      France.
FAU - Himbert, Dominique
AU  - Himbert D
AD  - Department of Cardiology, Assistance Publique-Hopitaux de Paris, Bichat Hospital, 
      Paris, France INSERM U698 Bichat Hospital, Paris, France.
FAU - Iung, Bernard
AU  - Iung B
AUID- ORCID: 0000-0002-9127-348X
AD  - Department of Cardiology, Assistance Publique-Hopitaux de Paris, Bichat Hospital, 
      Paris, France Faculte de Medecine Paris-Diderot University Paris 7, Paris, France 
      INSERM U698 Bichat Hospital, Paris, France.
FAU - Alos, Benjamin
AU  - Alos B
AD  - Department of Cardiology, Assistance Publique-Hopitaux de Paris, Bichat Hospital, 
      Paris, France.
FAU - Kerneis, Caroline
AU  - Kerneis C
AD  - Department of Cardiology, Assistance Publique-Hopitaux de Paris, Bichat Hospital, 
      Paris, France.
FAU - Ghodbane, Walid
AU  - Ghodbane W
AD  - Department of Cardiology, Assistance Publique-Hopitaux de Paris, Bichat Hospital, 
      Paris, France.
FAU - Messika-Zeitoun, David
AU  - Messika-Zeitoun D
AD  - Department of Cardiology, Assistance Publique-Hopitaux de Paris, Bichat Hospital, 
      Paris, France Faculte de Medecine Paris-Diderot University Paris 7, Paris, France 
      INSERM U698 Bichat Hospital, Paris, France.
FAU - Brochet, Eric
AU  - Brochet E
AD  - Department of Cardiology, Assistance Publique-Hopitaux de Paris, Bichat Hospital, 
      Paris, France.
FAU - Fassa, Amir-Ali
AU  - Fassa AA
AD  - Department of Cardiology, Assistance Publique-Hopitaux de Paris, Bichat Hospital, 
      Paris, France.
FAU - Depoix, Jean-Pol
AU  - Depoix JP
AD  - Department of Cardiology, Assistance Publique-Hopitaux de Paris, Bichat Hospital, 
      Paris, France.
FAU - Ou, Phalla
AU  - Ou P
AD  - Department of Radiology, Assistance Publique-Hopitaux de Paris, Bichat Hospital, 
      Paris, France.
FAU - Nataf, Patrick
AU  - Nataf P
AD  - Department of Cardiology, Assistance Publique-Hopitaux de Paris, Bichat Hospital, 
      Paris, France Faculte de Medecine Paris-Diderot University Paris 7, Paris, 
      France.
FAU - Vahanian, Alec
AU  - Vahanian A
AD  - Department of Cardiology, Assistance Publique-Hopitaux de Paris, Bichat Hospital, 
      Paris, France Faculte de Medecine Paris-Diderot University Paris 7, Paris, France 
      INSERM U698 Bichat Hospital, Paris, France.
LA  - eng
PT  - Journal Article
DEP - 20150205
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
SB  - IM
CIN - Nat Rev Cardiol. 2015 Apr;12(4):195. PMID: 25707387
CIN - Heart. 2015 Jun;101(12):913-4. PMID: 25903837
MH  - Aged, 80 and over
MH  - Aortic Valve Stenosis/mortality/*surgery
MH  - Follow-Up Studies
MH  - Humans
MH  - Postoperative Complications
MH  - Quality of Life
MH  - *Transcatheter Aortic Valve Replacement
MH  - Treatment Outcome
EDAT- 2015/02/07 06:00
MHDA- 2015/08/19 06:00
CRDT- 2015/02/07 06:00
PHST- 2014/08/21 00:00 [received]
PHST- 2015/01/15 00:00 [accepted]
PHST- 2015/02/07 06:00 [entrez]
PHST- 2015/02/07 06:00 [pubmed]
PHST- 2015/08/19 06:00 [medline]
AID - heartjnl-2014-306694 [pii]
AID - 10.1136/heartjnl-2014-306694 [doi]
PST - ppublish
SO  - Heart. 2015 Jun;101(12):936-42. doi: 10.1136/heartjnl-2014-306694. Epub 2015 Feb 
      5.