PMID- 25655256
OWN - NLM
STAT- MEDLINE
DCOM- 20151204
LR  - 20181113
IS  - 1573-2584 (Electronic)
IS  - 0301-1623 (Linking)
VI  - 47
IP  - 3
DP  - 2015 Mar
TI  - The protective effect of MCP-1 -2518 A>G promoter polymorphism in Turkish chronic 
      renal failure patients requiring long-term hemodialysis.
PG  - 551-6
LID - 10.1007/s11255-015-0922-3 [doi]
AB  - OBJECTIVE: Monocyte chemoattractant protein-1 (MCP-1) plays a major role in the 
      pathogenesis and progression of different types of human renal disease. 
      Therefore, in this study, we aimed to investigate the effect of MCP-1 gene -2518 
      A>G promoter polymorphism in chronic renal failure (CRF) patients requiring 
      long-term hemodialysis. METHODS: The study population consisted of 201 adult CRF 
      patients requiring long-term hemodialysis and 194 healthy controls. The 
      polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) 
      technique was used for genotyping of MCP-1 -2518 A>G polymorphism in the CRF 
      patients and healthy controls. RESULTS: There were statistically significant 
      differences in terms of genotypic (chi (2) = 12.69, p = 0.02) and allelic (chi (2) = 
      5.72, p = 0.02) frequencies of MCP-1 -2518 A>G between CRF patients and control 
      subjects. According to our results, in the patient group MCP-1 -2518 AA genotype 
      frequency was significantly higher than that of control group. On the other hand, 
      heterozygous AG genotype frequency in the control group was significantly higher 
      than that of the study group. Three different main disease subgroups of CRF 
      (hypertension, diabetes mellitus, and atherosclerosis) patients were also 
      evaluated, and significant associations were found between hypertension 
      (genotype: chi (2) = 9.28, p = 0.01; allele: chi (2) = 6.00, p = 0.01), 
      atherosclerosis (genotype: chi (2) = 5.37, p = 0.02; allele: chi (2) = 4.13, p = 
      0.04), and distributions of MCP-1 -2518 A>G genotypes and alleles. However, no 
      significant association was found between diabetes mellitus and distributions of 
      MCP-1 -2518 A>G genotype and allele frequencies (genotype: chi (2) = 2.37, p = 0.3; 
      allele: chi (2) = 1.88, p = 0.17). CONCLUSION: Current data show that MCP-1 -2518 
      AA genotype may cause susceptibility to CRF, while G allele may have a protective 
      effect against development of CRF. In addition, MCP-1 -2518 AA genotype seems to 
      associate with CRF originated from hypertension and atherosclerosis in our study 
      population.
FAU - Bagci, Binnur
AU  - Bagci B
AD  - Department of Nutrition and Dietetics, Faculty of Health Sciences, Cumhuriyet 
      University, Sivas, Turkey, binnur.koksal@hotmail.com.
FAU - Bagci, Gokhan
AU  - Bagci G
FAU - Candan, Ferhan
AU  - Candan F
FAU - Ozdemir, Ozturk
AU  - Ozdemir O
FAU - Sezgin, Ilhan
AU  - Sezgin I
LA  - eng
PT  - Journal Article
DEP - 20150206
PL  - Netherlands
TA  - Int Urol Nephrol
JT  - International urology and nephrology
JID - 0262521
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Atherosclerosis/complications/genetics
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics
MH  - Diabetic Nephropathies/genetics
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Hypertension/complications/genetics
MH  - Kidney Failure, Chronic/complications/*genetics/*therapy
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
MH  - Renal Dialysis
MH  - Time Factors
MH  - Turkey
EDAT- 2015/02/07 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/02/07 06:00
PHST- 2014/11/12 00:00 [received]
PHST- 2015/01/27 00:00 [accepted]
PHST- 2015/02/07 06:00 [entrez]
PHST- 2015/02/07 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.1007/s11255-015-0922-3 [doi]
PST - ppublish
SO  - Int Urol Nephrol. 2015 Mar;47(3):551-6. doi: 10.1007/s11255-015-0922-3. Epub 2015 
      Feb 6.