PMID- 25655797
OWN - NLM
STAT- MEDLINE
DCOM- 20150903
LR  - 20221207
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 56
IP  - 3
DP  - 2015 Feb 5
TI  - Peripapillary choroidal thickness in young Asians with high myopia.
PG  - 1475-81
LID - 10.1167/iovs.14-15742 [doi]
AB  - PURPOSE: To describe the topography and predictors of peripapillary choroidal 
      thickness (PPCT) in highly myopic eyes of young, healthy, Asian subjects. 
      METHODS: A total of 870 young male subjects aged 21.63 +/- 1.15 years were 
      recruited from the Singapore military. Choroidal imaging was performed using 
      enhanced depth imaging (EDI) spectral-domain optical coherence tomography 
      (SD-OCT). Peripapillary choroidal thickness was manually measured at eight 
      locations around the optic disc. RESULTS: We analyzed 448 subjects with high 
      myopia (defined as spherical equivalent [SE] worse than -6.0 diopters [D]) and 
      116 with emmetropia (SE > -0.5 and < 0.5 D). The mean SE was -8.52 +/- 1.20 D for 
      the high-myopic group, and 0.11 +/- 0.24 D for the emmetropic group. The mean 
      peripapillary choroid was significantly thinner (142.62 +/- 43.84 mum) in high 
      myopes compared with emmetropes (181.90 +/- 46.43 mum, P < 0.001). Likewise, PPCT 
      showed further decrease with increase in degree of myopic refractive error. 
      Distribution of PPCT showed a markedly different pattern in high-myopic eyes 
      (thickest superiorly) and emmetropic eyes (thickest temporally). However, 
      peripapillary choroid in both the groups was thinnest at the inferior location. 
      Among the ocular factors studied, axial length, IOP, presence of posterior 
      staphyloma, and chorioretinal atrophy were the factors significantly associated 
      with PPCT. CONCLUSIONS: Highly myopic eyes have significantly thinner 
      peripapillary choroid and showed different distribution of thickness, compared 
      with emmetropes. Axial length, IOP, and presence of posterior staphyloma and 
      chorioretinal atrophy significantly influence PPCT and should be taken into 
      consideration during clinical interpretation of PPCT measurement.
CI  - Copyright 2015 The Association for Research in Vision and Ophthalmology, Inc.
FAU - Gupta, Preeti
AU  - Gupta P
AD  - Singapore Eye Research Institute and Singapore National Eye Centre, Singapore 
      Department of Ophthalmology, Yong Loo Lin School of Medicine, National University 
      of Singapore and National University Health System, Singapore.
FAU - Cheung, Carol Y
AU  - Cheung CY
AD  - Singapore Eye Research Institute and Singapore National Eye Centre, Singapore.
FAU - Saw, Seang-Mei
AU  - Saw SM
AD  - Singapore Eye Research Institute and Singapore National Eye Centre, Singapore.
FAU - Bhargava, Mayuri
AU  - Bhargava M
AD  - Singapore Eye Research Institute and Singapore National Eye Centre, Singapore 
      Department of Ophthalmology, Yong Loo Lin School of Medicine, National University 
      of Singapore and National University Health System, Singapore.
FAU - Tan, Colin S
AU  - Tan CS
AD  - National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore Fundus 
      Image Reading Center, National Healthcare Group Eye Institute, Singapore.
FAU - Tan, Mellisa
AU  - Tan M
AD  - DSO National Laboratories, Defence Medical and Environmental Research Institute, 
      Singapore.
FAU - Yang, Adeline
AU  - Yang A
AD  - DSO National Laboratories, Defence Medical and Environmental Research Institute, 
      Singapore.
FAU - Tey, Frederick
AU  - Tey F
AD  - DSO National Laboratories, Defence Medical and Environmental Research Institute, 
      Singapore.
FAU - Nah, Gerard
AU  - Nah G
AD  - Department of Ophthalmology, Yong Loo Lin School of Medicine, National University 
      of Singapore and National University Health System, Singapore Vision Performance 
      Centre, Military Medical Institute, Singapore Armed Forces, Singapore.
FAU - Zhao, Paul
AU  - Zhao P
AD  - Department of Ophthalmology, Yong Loo Lin School of Medicine, National University 
      of Singapore and National University Health System, Singapore Vision Performance 
      Centre, Military Medical Institute, Singapore Armed Forces, Singapore.
FAU - Wong, Tien Yin
AU  - Wong TY
AD  - Singapore Eye Research Institute and Singapore National Eye Centre, Singapore.
FAU - Cheng, Ching-Yu
AU  - Cheng CY
AD  - Singapore Eye Research Institute and Singapore National Eye Centre, Singapore.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150205
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - Chorioretinal atrophy, progressive bifocal
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Asian People
MH  - Choroid/*pathology
MH  - Corneal Dystrophies, Hereditary/ethnology/pathology
MH  - Emmetropia/physiology
MH  - Fundus Oculi
MH  - Humans
MH  - Male
MH  - Myopia/*ethnology/*pathology
MH  - Optic Disk/*pathology
MH  - Optic Disk Drusen/ethnology/pathology
MH  - Optical Imaging
MH  - Reference Values
MH  - Refraction, Ocular/physiology
MH  - Tomography, Optical Coherence/methods
MH  - Young Adult
OTO - NOTNLM
OT  - myopia
OT  - peripapillary choroidal thickness
OT  - spectral-domain optical coherence tomography
EDAT- 2015/02/07 06:00
MHDA- 2015/09/04 06:00
CRDT- 2015/02/07 06:00
PHST- 2015/02/07 06:00 [entrez]
PHST- 2015/02/07 06:00 [pubmed]
PHST- 2015/09/04 06:00 [medline]
AID - iovs.14-15742 [pii]
AID - 10.1167/iovs.14-15742 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2015 Feb 5;56(3):1475-81. doi: 10.1167/iovs.14-15742.