PMID- 25656604 OWN - NLM STAT- MEDLINE DCOM- 20150713 LR - 20220331 IS - 1502-7732 (Electronic) IS - 0300-9742 (Linking) VI - 44 IP - 3 DP - 2015 May TI - Determination of the minimal clinically important difference for seven measures of fatigue in Swedish patients with systemic lupus erythematosus. PG - 206-10 LID - 10.3109/03009742.2014.988173 [doi] AB - OBJECTIVE: To estimate the minimal clinically important difference (MCID) in seven self-administered measures assessing fatigue in Swedish patients with systemic lupus erythematosus (SLE). METHOD: The participants (n = 51, women 98%, age 52.8 +/- 12.1 years, disease duration 18.7 +/- 13.6 years) met in groups of six to nine persons. After completing seven fatigue questionnaires [the Fatigue Severity Scale (FSS); the Multidimensional Assessment of Fatigue (MAF) scale; the 20-item Multidimensional Fatigue Inventory (MFI); the Chalder Fatigue Scale (CFS); the Short Form-36 Vitality subscale (VT); the Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-F) scale; and the Numeric Rating Scale (NRS)], each respondent had a minimum of five face-to-face discussions, followed by an individual comparative assessment of their own level of fatigue (seven-grade scale). This method resulted in 260 contrasting assessments; MCIDs were first calculated using the paired differences and then established by a regression approach. Patients were asked to comment on their experience with the questionnaires and whether they captured their fatigue adequately. RESULTS: The paired approach (using 'little more fatigue' as an anchor for MCID during the face-to-face comparative assessments) provided estimates of 4.6-17.0; the regression approach provided estimates of 4.3-10.8. Estimates using the regression approach were consistently lower than those using the paired model. The MCID estimates were least favourable and fewer respondents supported the use of the NRS compared to the other self-reported questionnaires. CONCLUSIONS: All seven instruments detect MCIDs for fatigue in Swedish patients with SLE. However, the single-question measure was not supported by the MCID estimates or by comments from the respondents. FAU - Pettersson, S AU - Pettersson S AD - Rheumatology Clinic, Karolinska University Hospital , Solna, Stockholm , Sweden. FAU - Lundberg, I E AU - Lundberg IE FAU - Liang, M H AU - Liang MH FAU - Pouchot, J AU - Pouchot J FAU - Henriksson, E Welin AU - Henriksson EW LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150206 PL - England TA - Scand J Rheumatol JT - Scandinavian journal of rheumatology JID - 0321213 SB - IM MH - Adult MH - Aged MH - Fatigue/*diagnosis/etiology MH - Female MH - Humans MH - Lupus Erythematosus, Systemic/complications/*diagnosis MH - Male MH - Middle Aged MH - Severity of Illness Index MH - Surveys and Questionnaires MH - Sweden EDAT- 2015/02/07 06:00 MHDA- 2015/07/15 06:00 CRDT- 2015/02/07 06:00 PHST- 2015/02/07 06:00 [entrez] PHST- 2015/02/07 06:00 [pubmed] PHST- 2015/07/15 06:00 [medline] AID - 10.3109/03009742.2014.988173 [doi] PST - ppublish SO - Scand J Rheumatol. 2015 May;44(3):206-10. doi: 10.3109/03009742.2014.988173. Epub 2015 Feb 6.